{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:19:32Z","timestamp":1790961572725,"version":"4.1.0"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Diabetic foot ulcers (DFU) are a prevalent complication of diabetes, leading to significant morbidity, mortality, and amputation rates. Chronic non-healing DFU often result from peripheral neuropathy, microvascular issues, and infection, with poor blood and oxygen supply being critical factors in delayed healing. The development of new treatments to promote blood supply and accelerate ulcer healing is a significant area of research for DFU management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this case series, nine patients with chronic diabetic ulcers received ultrasound-guided continuous parasacral ischial plane block (CPIPB) for 2 weeks, combined with standard care (SOC) for 12 weeks. Our objective was to assess the reduction in wound size and the rate of complete healing 12 weeks after the start of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the nine patients, six achieved complete healing of their diabetic foot ulcers, while the remaining three showed significant improvement with more than a 50% reduction in the initial ulcer area. This approach not only provided analgesia but also increased foot skin temperature and blood supply in the lower limb arteries, potentially promoting angiogenesis and revascularization. Local anesthetic leakage at the catheter insertion site occurred in two cases during CPIPB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CPIPB can promotes diabetic foot ulcer healing while providing effective analgesia in the lower limbs. This approach may offer a valuable complement to conventional treatments, particularly for patients with severe pain.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1580568","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T04:10:44Z","timestamp":1756095044000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: A case series of using ultrasound-guided continuous parasacral ischial plane blocks to promote ulcer healing and pain relief in people with diabetic foot ulcers"],"prefix":"10.3389","volume":"16","author":[{"given":"Peng","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanliang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1001\/jama.2023.10578","article-title":"Diabetic foot ulcers: A review","volume":"330","author":"Armstrong","year":"2023","journal-title":"Jama"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1221705","article-title":"Current status and progress in research on dressing management for diabetic foot ulcer","volume":"14","author":"Jiang","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/s41392-023-01400-z","article-title":"Diabetic vascular diseases: molecular mechanisms and therapeutic strategies","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.749368","article-title":"Heparin and related substances for treating diabetic foot ulcers: A systematic review and meta-analysis","volume":"13","author":"Su","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"11585","DOI":"10.1038\/s41598-020-68475-4","article-title":"The effect of epinephrine on the perfusion index during ultrasound-guided supraclavicular brachial plexus block: a randomized controlled trial","volume":"10","author":"Kim","year":"2020","journal-title":"Sci Rep"},{"key":"B6","article-title":"The effect of nerve block alone or with zinc on wound healing in a rat model of diabetic foot ulcer","volume":"28","author":"Shin","year":"2017","journal-title":"Biomed Research-tokyo"},{"key":"B7","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1186\/s13018-024-04822-9","article-title":"A proof-of-concept study of ultrasound-guided continuous parasacral ischial plane block for postoperative pain control in patients undergoing total knee arthroplasty","volume":"19","author":"Ye","year":"2024","journal-title":"J Orthop Surg Res"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S393379","article-title":"Evaluation of the antioxidant and wound healing properties of 80% Methanol extract and solvent fractions of the leaves of vernonia auriculifera hiern","volume":"16","author":"Ashenafi","year":"2023","journal-title":"(Asteraceae). 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