{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T01:12:58Z","timestamp":1755825178187,"version":"3.44.0"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To establish and validate a nomogram model for the quality of sleep in patients with recurrent implantation failure (RIF) and to evaluate its performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 2023 to June 2023, 484 RIF patients who underwent ART fertilization treatment at the Reproductive Medicine Center of Tongji University-affiliated Obstetrics and Gynecology Hospital were selected as the modeling set and internal validation. Additionally, from July to September 2023, 223 RIF patients who underwent ART fertilization treatment at the Reproductive Medicine Center of Tongji University-affiliated Obstetrics and Gynecology Hospital were chosen as the external validation set. Their clinical data was collected. Lasso regression was used to screen potential predictive variables and multifactor logistic regression analysis was conducted to determine the final predictors. A nomogram model was established, and the model was evaluated using methods such as plotting receiver operating characteristic (ROC) curves, calibration curves, Hosmer-Lemeshow goodness of fit test, and decision curve analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Through Lasso regression and multifactor logistic regression, 7 predictors were identified, including FSH, E2, depression mood (moderate, severe), daily exercise time, sun exposure, caffeine intake, and shift work (&amp;gt;16h\/w) for constructing the nomogram model. The AUC for the modeling set was 0.971 (95%CI:0.952\u223c0.989), for the internal validation set was 0.960 (95%CI:0.937\u223c0.979), and for the external validation set was 0.850 (95%CI:0.739\u223c0.960), indicating good predictive performance of the model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study established and validated a nomogram model composed of 7 clinical indicators for sleep disorders in RIF patients. The predictors include both physiological indicators and daily lifestyle habits, demonstrating significant predictive value and clinical application efficiency. It can be used for early identification of potential sleep disorders in RIF patients, providing certain reference significance for clinical work.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1585144","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T04:11:35Z","timestamp":1755749495000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and validation of a nomogram model for sleep disorders in patients with recurrent implantation failure based on physiological and lifestyle factors"],"prefix":"10.3389","volume":"16","author":[{"given":"You","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningxin","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengjia","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3760\/cma.j.cn112137-20221105-02317","article-title":"Chinese expert consensus on the clinical diagnosis and treatment of recurrent implantation failure","volume":"103","year":"2023","journal-title":"Chin Med J"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2019.10.014","article-title":"How common is real repeated implantation failure? An indirect estimate of the prevalence","volume":"40","author":"Busnelli","year":"2020","journal-title":"Reprod BioMed Online"},{"key":"B3","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.pcad.2023.02.005","article-title":"Sleep physiology, pathophysiology, and sleep hygiene","volume":"77","author":"Baranwal","year":"2023","journal-title":"Prog Cardiovasc Dis"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000554","article-title":"Sleep and female reproduction","volume":"31","author":"Willis","year":"2019","journal-title":"Curr Opin Obstet Gynecol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.16781\/j.CN31-2187\/R.20230211","article-title":"Paying attention to sleep and caring for health: interpretation of \"China sleep research report 2023","volume":"44","author":"He","year":"2023","journal-title":"J Naval Med Univ"},{"key":"B6","doi-asserted-by":"publisher","first-page":"m441","DOI":"10.1136\/bmj.m441","article-title":"Calculating the sample size required for developing a clinical prediction model","volume":"368","author":"Riley","year":"2020","journal-title":"BMJ"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn113694-20240406-00209","article-title":"Chinese adult insomnia diagnosis and treatment guidelines (2023 edition)","volume":"57","year":"2024","journal-title":"Chin J Neurol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S440778","article-title":"The impact of using donor sperm after ICSI failure in severe oligozoospermia on male mental health and erectile function","volume":"4","author":"Yin","year":"2024","journal-title":"J Multidiscip Healthc"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S494319","article-title":"Effect of donor sperm on quality of life in patients with severe oligoasthenosperm after ICSI failure","volume":"18","author":"Wang","year":"2025","journal-title":"J Multidiscip Healthc"},{"key":"B10","doi-asserted-by":"publisher","first-page":"17477","DOI":"10.1038\/s41598-022-22534-0","article-title":"Women's quality of sleep and in vitro fertilization success","volume":"12","author":"Reschini","year":"2022","journal-title":"Sci Rep"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9868.2011.01004.x","article-title":"A study on sleep related breathing disorders among COPD patients","volume":"9","author":"Tibshirani","year":"2022","journal-title":"Eur J Mol Clin Med"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00803","article-title":"Endogenous circadian regulation of female reproductive hormones","volume":"104","author":"Rahman","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2012.01007.x","article-title":"Perceived poor sleep quality in the absence of polysomnographic sleep disturbance in women with severe premenstrual syndrome","volume":"21","author":"Baker","year":"2012","journal-title":"J Sleep Res"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleh.2021.10.011","article-title":"Sleep, psychological distress, and clinical pregnancy outcome in women and their partners undergoing in vitro or intracytoplasmic sperm injection fertility treatment","volume":"8","author":"Philipsen","year":"2022","journal-title":"Sleep Health"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2021.07.037","article-title":"Evaluation of depression and sleep disorders in the preoperative and postoperative period in stage 4 endometriosis patients","volume":"264","author":"Goksu","year":"2021","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1530\/rep.0.1250151","article-title":"A conceptual model ofthe influence of stress on female reproduction","volume":"125","author":"Dobson","year":"2003","journal-title":"Reproduction"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2018.11.009","article-title":"Can 24 weeks strength training reduce feelings of depression and increase neurotransmitter in elderly females","volume":"115","author":"Kim","year":"2019","journal-title":"Exp Gerontol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"106052","DOI":"10.1016\/j.phrs.2021.106052","article-title":"Effects of exogenous melatonin supplementation on health outcomes: An umbrella review of meta-analyses based on randomized controlled trials","volume":"176","author":"Lim","year":"2022","journal-title":"Pharmacol Res"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbadis.2020.165823","article-title":"Exercise-induced immune system response: antiinflammatory status on peripheral and central organs","volume":"1866","author":"Scheffer","year":"2020","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5334\/jcr.190","article-title":"Sleep and reproductive health","volume":"18","author":"Lateef","year":"2020","journal-title":"J Circadian Rhythms"},{"key":"B21","doi-asserted-by":"publisher","first-page":"89","DOI":"10.16305\/j.1007-1334.2024.2308016","article-title":"Effects of Yishen Ningxin Formula on behavior and neurotransmitter in sleep deprivation induced zebrafish","volume":"58","author":"Zhang","year":"2024","journal-title":"Shanghai J Tradit Chin Med"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/sleepadvances\/zpad035.050","article-title":"O050 the dose and timing relationship between caffeine and subsequent sleep","volume":"4","author":"Gardiner","year":"2023","journal-title":"SLEEP Adv"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1585144\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T04:11:38Z","timestamp":1755749498000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1585144\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,21]]},"references-count":22,"alternative-id":["10.3389\/fendo.2025.1585144"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2025.1585144","relation":{},"ISSN":["1664-2392"],"issn-type":[{"type":"electronic","value":"1664-2392"}],"subject":[],"published":{"date-parts":[[2025,8,21]]},"article-number":"1585144"}}