{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:51:51Z","timestamp":1753890711740,"version":"3.41.2"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["14\/03989-6, 19\/00860-6, 19\/00849-2"],"award-info":[{"award-number":["14\/03989-6, 19\/00860-6, 19\/00849-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Over the past decade, advancements in next-generation sequencing have significantly enhanced our understanding of the molecular pathogenesis of adamantinomatous craniopharyngiomas (ACP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study integrated methylome and transcriptome analyses in ACP samples to explore the potential interplay between DNA methylation and RNA expression signatures for diagnostic and prognostic applications in ACP patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross-sectional study evaluated clinicopathological features, DNA methylation, and gene expression profiles in 15 patients with ACP (33% women, age range: 3\u201355 years, 53% diagnosed before 18 years) treated at Ribeirao Preto Medical School, University of S\u00e3o Paulo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multidimensional scaling and principal component analysis identified two distinct clusters (ACP-A: n=9, ACP-B: n=6) with consistent composition across DNA methylation and gene expression profiles. While most clinical and histopathological characteristics were similar between clusters, ACP-A exhibited a longer median progression-free survival. ACP-B showed a higher prevalence of hypomethylated probes in CGI sites, and 63% of differentially methylated positions (DMPs) located in gene body regions. Differential methylation patterns were categorized into Methyl-Set1 (hypomethylated in ACP-A and hypermethylated in ACP-B) and Methyl-Set2 (hypermethylated in ACP-A and hypomethylated in ACP-B). Clustering analyses based on the methylation levels of probes and expression levels of the stringently filtered 212- and 37-gene sets further confirmed these two distinct ACP subgroups. Functional enrichment analysis highlighted key roles in synaptic modulation, nervous system development, cell adhesion, as well as pathways linked to RAS signaling, GTPase activity, and membrane potential regulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although clinical characteristics were largely comparable between the clusters, ACP-B patients exhibited shorter median progression-free survival, suggesting a more aggressive phenotype. The higher prevalence of hypomethylation in ACP-B indicates increased transcriptional activation, potentially driving tumor aggressiveness. The strong concordance between methylation and transcriptomic data in the 212- and 37-gene sets underscores their potential as a clinically relevant molecular biomarker panel. These gene sets demonstrate robustness in distinguishing ACP clusters, making it a promising tool for clinical sample classification.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1585618","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T04:11:09Z","timestamp":1749701469000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Methylation and gene expression patterns in adamantinomatous craniopharyngioma highlight a panel of genes associated with disease progression-free survival"],"prefix":"10.3389","volume":"16","author":[{"given":"Junier","family":"Marrero-Guti\u00e9rrez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina","family":"Bueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarissa Silva","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui Milton Patr\u00edcio","family":"Silva-J\u00fanior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f4nio Carlos dos","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Volpon","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Eduardo","family":"Wildemberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ximene Lima da Silva","family":"Antunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica R.","family":"Gadelha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayrton Custodio","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Zorzetto Nicoliello","family":"V\u00eancio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonir Roberto R.","family":"Antonini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"de Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-011-0540-6","article-title":"Incidence of craniopharyngioma in Denmark (n = 189) and estimated world incidence of craniopharyngioma in children and adults","volume":"104","author":"Nielsen","year":"2011","journal-title":"J Neurooncol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-021-01127-6","article-title":"Descriptive epidemiology of craniopharyngiomas in the United States","volume":"24","author":"Momin","year":"2021","journal-title":"Pituitary"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1159\/000512161","article-title":"Craniopharyngioma in the elderly: A multicenter and nationwide study in Spain","volume":"111","author":"Iglesias","year":"2021","journal-title":"Neuroendocrinology"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.20945\/2359-3997000000600","article-title":"The molecular pathogenesis of craniopharyngiomas","volume":"67","author":"Campanini","year":"2023","journal-title":"Arch Endocrinol Metab"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1210\/er.2006-0002","article-title":"Craniopharyngiomas","volume":"27","author":"Karavitaki","year":"2006","journal-title":"Endocr Rev"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6953","article-title":"Comparison of neuroendocrine dysfunction in patients with adamantinomatous and papillary craniopharyngiomas","volume":"17","author":"Feng","year":"2019","journal-title":"Exp Ther Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1159\/000506904","article-title":"Biological behaviour of craniopharyngiomas","volume":"110","author":"Martinez-Barbera","year":"2020","journal-title":"Neuroendocrinology"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/path.v203:3","article-title":"Possible linkage between specific histological structures and aberrant reactivation of the Wnt pathway in adamantinomatous craniopharyngioma","volume":"203","author":"Kato","year":"2004","journal-title":"J Pathol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-005-1004-x","article-title":"Common mutations of \u03b2-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region","volume":"109","author":"Buslei","year":"2005","journal-title":"Acta Neuropathol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s40478-016-0287-6","article-title":"Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles","volume":"4","author":"H\u00f6lsken","year":"2016","journal-title":"Acta Neuropathol Commun"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-010-0041-7","article-title":"CTNNB1 gene mutations, pituitary transcription factors, and microRNA expression involvement in the pathogenesis of adamantinomatous craniopharyngiomas","volume":"1","author":"Campanini","year":"2010","journal-title":"Horm Canc"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2868","article-title":"Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas","volume":"46","author":"Brastianos","year":"2014","journal-title":"Nat Genet"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0957","article-title":"ENDOCRINE TUMORS: BRAF V600E mutations in papillary craniopharyngioma","volume":"174","author":"Brastianos","year":"2016","journal-title":"Eur J Endocrinol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1101553108","article-title":"Increased Wingless (Wnt) signaling in pituitary progenitor\/stem cells gives rise to pituitary tumors in mice and humans","volume":"108","author":"Gaston-Massuet","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B15","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1515\/jpem-2014-0442","article-title":"Adamantinomatous craniopharyngioma: pathology, molecular genetics and mouse models","volume":"28","author":"Martinez-Barbera","year":"2015","journal-title":"J Pediatr Endocrinol Metab"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-0957-9","article-title":"Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma","volume":"124","author":"Andoniadou","year":"2012","journal-title":"Acta Neuropathol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.07.004","article-title":"Sox2(+) stem\/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential","volume":"13","author":"Andoniadou","year":"2013","journal-title":"Cell Stem Cell"},{"key":"B18","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41572-019-0125-9","article-title":"Craniopharyngioma","volume":"5","author":"M\u00fcller","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2020.05.009","article-title":"Management of hypothalamic obesity","volume":"49","author":"M\u00fcller","year":"2020","journal-title":"Endocrinol Metab Clinics North A"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.05.174","article-title":"Current results of surgical treatment of craniopharyngiomas: the impact of endoscopic endonasal approaches","volume":"142","author":"Almeida","year":"2020","journal-title":"World Neurosurg"},{"key":"B21","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1023\/A:1006145724500","article-title":"Health status in 52 long-term survivors of pediatric brain tumors","volume":"41","author":"Foreman","year":"1999","journal-title":"J Neurooncol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz043","article-title":"Clinical situation, therapy, and follow-up of adult craniopharyngioma: report from the German craniopharyngioma registry","volume":"105","author":"Mende","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2015.06.001","article-title":"Nutritional and endocrinologic evaluation of patients with craniopharyngioma","volume":"10","author":"Nogueira","year":"2015","journal-title":"Clin Nutr ESPEN"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1830-2","article-title":"Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK\/ERK pathway as a novel therapeutic target","volume":"135","author":"Apps","year":"2018","journal-title":"Acta Neuropathol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s40478-015-0211-5","article-title":"Identification of targets for rational pharmacological therapy in childhood craniopharyngioma","volume":"3","author":"Gump","year":"2015","journal-title":"Acta Neuropathol Commun"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1016\/j.cell.2020.10.044","article-title":"Integrated proteogenomic characterization across major histological types of pediatric brain cancer","volume":"183","author":"Petralia","year":"2020","journal-title":"Cell"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000030278","article-title":"Hub genes for early diagnosis and therapy of adamantinomatous craniopharyngioma","volume":"101","author":"Zou","year":"2022","journal-title":"Med (Baltimore)"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae006","article-title":"Epigenetic control of adamantinomatous craniopharyngiomas","volume":"109","author":"Marrero-Guti\u00e9rrez","year":"2024","journal-title":"J Clin Endocrinol Metab"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-21-1269","article-title":"Telomere length and Wnt\/\u03b2-catenin pathway in adamantinomatous craniopharyngiomas","volume":"187","author":"Mota","year":"2022","journal-title":"Eur J Endocrinol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac703","article-title":"Integrating methylome and transcriptome signatures expands the molecular classification of the pituitary tumors","volume":"108","author":"da Silva-J\u00fanior","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30053-8","article-title":"Hypopituitarism","volume":"388","author":"Higham","year":"2016","journal-title":"Lancet"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.2223\/JPED.1502","article-title":"Body mass index cutoff points for evaluation of nutritional status in Brazilian children and adolescents","volume":"82","author":"Conde","year":"2006","journal-title":"J Pediatr (Rio J)"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-018-1752-8","article-title":"Are volume measurements of non-functioning pituitary adenomas reliable","volume":"63","author":"\u00d8ystese","year":"2019","journal-title":"Endocrine"},{"key":"B34","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3171\/ped.2007.106.1.3","article-title":"Pediatric craniopharyngiomas: classification and treatment according to the degree of hypothalamic involvement","volume":"106","author":"Puget","year":"2007","journal-title":"J Neurosurg"},{"key":"B35","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1186\/1471-2105-11-587","article-title":"Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis","volume":"11","author":"Du","year":"2010","journal-title":"BMC Bioinf"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu049","article-title":"Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays","volume":"30","author":"Aryee","year":"2014","journal-title":"Bioinformatics"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.2217\/epi.12.21","article-title":"Complete pipeline for Infinium \u00ae Human Methylation 450K BeadChip data processing using subset quantile normalization for accurate DNA methylation estimation","volume":"4","author":"Touleimat","year":"2012","journal-title":"Epigenomics"},{"key":"B38","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/s13059-016-1066-1","article-title":"Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling","volume":"17","author":"Pidsley","year":"2016","journal-title":"Genome Biol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/nature26000","article-title":"DNA methylation-based classification of central nervous system tumours","volume":"555","author":"Capper","year":"2018","journal-title":"Nature"},{"key":"B40","article-title":"Tumor DNA methylation profiling of patients with Adamantinomatous craniopharyngioma (ACP)","volume-title":"Gene Expression Omnibus","author":"Marrero-Guti\u00e9rrez","year":"2024"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"B42","doi-asserted-by":"publisher","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol"},{"key":"B43","article-title":"Methylation and gene expression patterns in adamantinomatous craniopharyngioma highlight a panel of genes associated with disease progression-free survival","volume-title":"Gene Expression Omnibus","author":"Marrero-Guti\u00e9rrez","year":"2025"},{"volume-title":"R: A language and environment for statistical computing","year":"2012","key":"B44"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl117","article-title":"Pvclust: an R package for assessing the uncertainty in hierarchical clustering","volume":"22","author":"Suzuki","year":"2006","journal-title":"Bioinformatics"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v025.i01","article-title":"FactoMineR: an R package for multivariate analysis","volume":"25","author":"L\u00ea","year":"2008","journal-title":"J Stat Soft"},{"key":"B47","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"B48","unstructured":"Hmisc\n          \n          \n            \n              Harrell\n              FE\n              Jr\n            \n            \n              Dupont\n              C\n            \n          \n          \n          2025"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt311","article-title":"Gene-set analysis is severely biased when applied to genome-wide methylation data","volume":"29","author":"Geeleher","year":"2013","journal-title":"Bioinformatics"},{"key":"B50","doi-asserted-by":"publisher","first-page":"100141","DOI":"10.1016\/j.xinn.2021.100141","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(98)01636-9","article-title":"The DNA methylation paradox","volume":"15","author":"Jones","year":"1999","journal-title":"Trends Genet"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra072067","article-title":"Epigenetics in cancer","volume":"358","author":"Esteller","year":"2008","journal-title":"N Engl J Med"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/nrg816","article-title":"The fundamental role of epigenetic events in cancer","volume":"3","author":"Jones","year":"2002","journal-title":"Nat Rev Genet"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-2033","article-title":"Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung","volume":"14","author":"Licchesi","year":"2008","journal-title":"Clin Cancer Res"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"B56","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1242\/dev.126.3.495","article-title":"prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme","volume":"126","author":"Lu","year":"1999","journal-title":"Development"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1002\/mc.v55.12","article-title":"PRRX2 as a novel TGF-\u03b2-induced factor enhances invasion and migration in mammary epithelial cell and correlates with poor prognosis in breast cancer","volume":"55","author":"Juang","year":"2016","journal-title":"Mol Carcinog"},{"key":"B58","doi-asserted-by":"publisher","first-page":"152593","DOI":"10.1016\/j.prp.2019.152593","article-title":"Inhibition of PRRX2 suppressed colon cancer liver metastasis via inactivation of Wnt\/\u03b2-catenin signaling pathway","volume":"215","author":"Chai","year":"2019","journal-title":"Pathol Res Pract"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt643","article-title":"Integrated analysis of genome-wide DNA methylation and gene expression profiles in molecular subtypes of breast cancer","volume":"41","author":"Rhee","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"B60","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41392-019-0081-6","article-title":"Integrative analysis of DNA methylation and gene expression identified cervical cancer-specific diagnostic biomarkers","volume":"4","author":"Xu","year":"2019","journal-title":"Signal Transduct Target Ther"},{"key":"B61","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1158\/1541-7786.MCR-16-0494","article-title":"Epigenetic regulation of ZBTB18 promotes glioblastoma progression","volume":"15","author":"Fedele","year":"2017","journal-title":"Mol Cancer Res"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.v161.3","article-title":"Understanding the impact of ZBTB18 missense variation on transcription factor function in neurodevelopment and disease","volume":"161","author":"Heng","year":"2022","journal-title":"J Neurochem"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1038\/s42003-024-07144-y","article-title":"ZBTB18 regulates cytokine expression and affects microglia\/macrophage recruitment and commitment in glioblastoma","volume":"7","author":"Ferrarese","year":"2024","journal-title":"Commun Biol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3390\/cells11142128","article-title":"The glycoprotein M6a is associated with invasiveness and radioresistance of glioblastoma stem cells","volume":"11","author":"Lacore","year":"2022","journal-title":"Cells"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.02.008","article-title":"The GABA transaminase, ABAT, is essential for mitochondrial nucleoside metabolism","volume":"21","author":"Besse","year":"2015","journal-title":"Cell Metab"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2015.02.006","article-title":"Decreased expression of ABAT and STC2 hallmarks ER-positive inflammatory breast cancer and endocrine therapy resistance in advanced disease","volume":"9","author":"Jansen","year":"2015","journal-title":"Mol Oncol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228485","article-title":"A targeted bioinformatics assessment of adrenocortical carcinoma reveals prognostic implications of GABA system gene expression","volume":"21","author":"Knott","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.879810","article-title":"Regulation of gamma-aminobutyric acid transaminase expression and its clinical significance in hepatocellular carcinoma","author":"Gao","year":"2022","journal-title":"Front Oncol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2022.08.004","article-title":"GABAergic signaling beyond synapses: an emerging target for cancer therapy","volume":"33","author":"Huang","year":"2023","journal-title":"Trends Cell Biol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/s41598-021-04127-5","article-title":"GFAP splice variants fine-tune glioma cell invasion and tumour dynamics by modulating migration persistence","volume":"12","author":"Uceda-Castro","year":"2022","journal-title":"Sci Rep"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16017","article-title":"The potential roles of aquaporin 4 in Malignant gliomas","volume":"8","author":"Lan","year":"2017","journal-title":"Oncotarget"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3677","article-title":"Hippocampal synaptic plasticity, spatial memory and anxiety","volume":"15","author":"Bannerman","year":"2014","journal-title":"Nat Rev Neurosci"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3390\/jcm4091774","article-title":"Hypothalamic obesity in craniopharyngioma patients: disturbed energy homeostasis related to extent of hypothalamic damage and its implication for obesity intervention","volume":"4","author":"Roth","year":"2015","journal-title":"JCM"},{"key":"B74","doi-asserted-by":"publisher","first-page":"110467","DOI":"10.1016\/j.celrep.2022.110467","article-title":"Single nucleus transcriptome and chromatin accessibility of postmortem human pituitaries reveal diverse stem cell regulatory mechanisms","volume":"38","author":"Zhang","year":"2022","journal-title":"Cell Rep"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002774","article-title":"Multi-omics analysis of adamantinomatous craniopharyngiomas reveals distinct molecular subgroups with prognostic and treatment response significance","volume":"137","author":"Wang","year":"2024","journal-title":"Chin Med J (Engl)"},{"key":"B76","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/s41419-024-06840-1","article-title":"Multiomics integration-based immunological characterizations of adamantinomatous craniopharyngioma in relation to keratinization","volume":"15","author":"Xu","year":"2024","journal-title":"Cell Death Disease"},{"key":"B77","doi-asserted-by":"publisher","first-page":"216905","DOI":"10.1016\/j.canlet.2024.216905","article-title":"Axl as a potential therapeutic target for adamantinomatous craniopharyngiomas: Based on single nucleus RNA-seq and spatial transcriptome profiling","volume":"592","author":"Chen","year":"2024","journal-title":"Cancer Lett"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1585618\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T04:11:13Z","timestamp":1749701473000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1585618\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,12]]},"references-count":77,"alternative-id":["10.3389\/fendo.2025.1585618"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2025.1585618","relation":{},"ISSN":["1664-2392"],"issn-type":[{"type":"electronic","value":"1664-2392"}],"subject":[],"published":{"date-parts":[[2025,6,12]]},"article-number":"1585618"}}