{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:45:42Z","timestamp":1787597142414,"version":"build-2736575974"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This review aims to investigate the relationship between impaired sensitivity to thyroid hormones and ASCVD risk factors in the euthyroid population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross-sectional study including 7,895 euthyroid subjects aged \u226518 years old was conducted. Height, body weight, blood pressure (BP) were measured, and serum concentrations of lipids, fasting blood glucose, uric acid, free thyroxine (FT4), free triiodothyronine (FT3), and thyrotropin (TSH) were assayed. Thyroid hormone resistance was calculated by Thyroid-stimulating hormone (TSHI), Thyroid Feedback Quantile-based Index (TFQI), and Free Triiodothyronine\/Free thyroxine (FT3\/FT4), which were calculated based on FT3, FT4, and TSH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We are divided into four groups according to the TFQI quartile. Age, BMI, BP, HDL-C, TC, TG, FBG, UA were statistically significant between the four groups. F3\/F4 showed statistical significance in populations with high UA, high FBG, and high TG; TFQI was positively correlated with BP, TG, FBG, UA and TyG, SBP, FBG, UA and TyG, FT3\/FT4 was negatively correlated with DBP, SBP, TC, TG and UA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Impaired sensitivity to thyroid hormone in euthyroid population is associated with ASCVD risk factors. These findings are potentially useful for understanding the interaction between thyroid hormone sensitivity and ASCVD risk factors in euthyroid population.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1602202","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T04:10:30Z","timestamp":1752725430000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Impaired sensitivity to thyroid hormones is associated with ASCVD risk factors in Beijing in euthyroid population: a cross-sectional study"],"prefix":"10.3389","volume":"16","author":[{"given":"Lintao","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiyun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfang","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0266","article-title":"Thyroid hormone as a determinant of energy expenditure and the basal metabolic rate","volume":"18","author":"Kim","year":"2008","journal-title":"Thyroid"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx050","article-title":"Subclinical thyroid dysfunction and cardiovascular diseases: 2016 update","volume":"39","author":"Floriani","year":"2018","journal-title":"Eur Heart J"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-4-200002150-00004","article-title":"Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study","volume":"132","author":"Hak","year":"2000","journal-title":"Ann Intern Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-022-03279-2","article-title":"Correlation between thyroid function, sensitivity to thyroid hormones and metabolic dysfunction-associated fatty liver disease in euthyroid subjects with newly diagnosed type 2 diabetes","volume":"80","author":"Zhang","year":"2023","journal-title":". 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