{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:34:17Z","timestamp":1787319257235,"version":"build-2736575974"},"reference-count":126,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>T2DM is a global health challenge characterized by insulin resistance and impaired glucose metabolism. Natural products, such as polysaccharides from medicinal plants, are increasingly explored for their potential in managing T2DM with fewer side effects compared to conventional drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      This review aims to comprehensively evaluate the effects of\n                      <jats:italic>Polygonati Rhizoma<\/jats:italic>\n                      Polysaccharide (PRP) on glucose and lipid metabolism in T2DM and elucidate its underlying molecular mechanisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      In recent years, numerous scientific studies have demonstrated that\n                      <jats:italic>Polygonati Rhizoma<\/jats:italic>\n                      Polysaccharide (PRP) exerts beneficial effects on type 2 diabetes mellitus (T2DM), enhancing both glucose and lipid metabolism. This article provides a comprehensive review of the impact of PRP on T2DM influencing glucose and lipid metabolism and elucidates the underlying molecular mechanisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was conducted across electronic databases including PubMed, Web of Science, Wanfang Database, and China National Knowledge Infrastructure (CNKI). The search encompassed publications from June 2010 to June 2025, representing a 15-year period. Titles and abstracts were systematically screened for relevance, after which full-text articles meeting the inclusion criteria within this timeframe were selected for analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Current evidence indicates that PRP can ameliorate T2DM alongside improving glucose and lipid profiles; this effect is predominantly linked to its modulation of the PI3K\/AKT signaling pathway. Furthermore, its lipid-lowering properties are associated with regulation of gut microbiota, enhancement of intestinal barrier function, promotion of short-chain fatty acids (SCFAs) production, activation of G Protein-Coupled Receptors 41 and 43 (GPCR41 and 43), as well as inhibition of the TLR4\/MyD88\/NF-\u03baB signaling cascade.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Polygonati Rhizoma<\/jats:italic>\n                      Polysaccharide can obviously improve the hyperglycemia and hyperlipidemia caused by T2DM, and has certain anti-inflammatory and antioxidant effects.\n                    <\/jats:p>\n                  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