{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T12:34:24Z","timestamp":1793709264809,"version":"4.6.1"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The relationship between the triglyceride-glucose index (TyG) and overactive bladder (OAB) is unclear. The aim of this study was to investigate the possible association between the TyG index and OAB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>National Health and Nutrition Examination Survey (NHANES) data from 2005\u20132018 were used. The association between TyG index and OAB was assessed using univariate and multivariate logistic regression models. In addition, restricted cubic spline curves were used to examine the dose-response relationship between TyG index and OAB risk. Subgroup analyses and interaction analyses were then performed to assess differences in associations between subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 14,059 participants with 3325 patients with OAB were included. In the fully adjusted model, each unit increase in the TyG index was associated with a 1.18-fold increased risk of OAB (OR = 1.18; 95% CI: 1.11-1.26; p &amp;lt; 0.001) and a 1.32-fold increased risk of OAB for Q4 compared to Q1 at the quartile level (OR = 1.32, 95% CI: 1.17- 1.50, p &amp;lt; 0.001), RCS analysis showed a positive linear association between TyG index and OAB, and subgroup analysis showed that the association between TyG and OAB was more pronounced in individuals younger than 60 years and in women (p for interaction &amp;lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study suggest that TyG index is positively associated with OAB, and this association was more pronounced in younger age groups and in females.TyG index, as a simple and cost-effective metabolic marker, may provide a potential tool for early screening of OAB, especially in individuals with metabolic abnormalities that have not progressed to significant metabolic diseases.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1610140","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T04:14:36Z","timestamp":1749010476000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Triglyceride-glucose index and overactive bladder syndrome: evidence from the NHANES 2005-2018"],"prefix":"10.3389","volume":"16","author":[{"given":"Baitong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiongming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanhui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-024-06029-2","article-title":"Global prevalence of overactive bladder: A systematic review and meta-analysis","author":"Zhang","year":"2025","journal-title":"Int Urogynecol J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1080\/2090598X.2023.2221403","article-title":"The prevalence of overactive bladder and its impact on the quality of life: A cross-sectional study","volume":"22","author":"Qudaha","year":"2024","journal-title":"Arab J Urol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2217\/cer-2022-0160","article-title":"Healthcare and economic burden of anticholinergic use in adults with overactive bladder: a systematic literature review","volume":"11","author":"Duperrouzel","year":"2022","journal-title":"J Comp Eff Res"},{"key":"B4","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.eururo.2013.08.031","article-title":"Global prevalence and economic burden of urgency urinary incontinence: a systematic review","volume":"65","author":"Milsom","year":"2014","journal-title":"Eur Urol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.03.096","article-title":"Oxidative stress and neurodegeneration in the ischemic overactive bladder","volume":"178","author":"Azadzoi","year":"2007","journal-title":"J Urol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"12579","DOI":"10.1038\/s41598-024-63448-3","article-title":"The association between\u00a0overactive bladder and systemic immunity-inflammation index: a cross-sectional study of NHANES 2005 to 2018","volume":"14","author":"Wei","year":"2024","journal-title":"Sci Rep"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-022-00621-1","article-title":"Potential role of oxidative stress in the pathogenesis of diabetic bladder dysfunction","volume":"19","author":"Song","year":"2022","journal-title":"Nat Rev Urol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e14765","DOI":"10.7759\/cureus.14765","article-title":"Association of metabolic syndrome components and overactive bladder in women","volume":"13","author":"Baytaroglu","year":"2021","journal-title":"Cureus"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2022.09.013","article-title":"Impaired insulin signaling at the bladder mucosa facilitates metabolic syndrome-associated bladder overactivity in rats with maternal and post-weaning fructose exposure","volume":"122","author":"Lee","year":"2023","journal-title":"J Formos Med Assoc"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-023-00842-3","article-title":"Insulin detection in diabetes mellitus: challenges and new prospects","volume":"19","author":"Vargas","year":"2023","journal-title":"Nat Rev Endocrinol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175672","article-title":"Effects of statin therapy on glycemic control and insulin resistance: A systematic review and meta-analysis","volume":"947","author":"Alvarez-Jimenez","year":"2023","journal-title":"Eur J Pharmacol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.numecd.2021.11.017","article-title":"Comparison of triglyceride-glucose index and HOMA-IR for predicting prevalence and incidence of metabolic syndrome","volume":"32","author":"Son","year":"2022","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2022.102581","article-title":"Challenges in the diagnosis of insulin resistance: Focusing on the role of HOMA-IR and Tryglyceride\/glucose index","volume":"16","author":"Tahapary","year":"2022","journal-title":"Diabetes Metab Syndr: Clin Res Rev"},{"key":"B14","doi-asserted-by":"publisher","first-page":"3700","DOI":"10.1016\/j.jaip.2023.09.001","article-title":"Metabolic dysfunction, triglyceride-glucose index, and risk of severe asthma exacerbation","volume":"11","author":"Staggers","year":"2023","journal-title":"J Allergy Clin Immunol: Pract"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.774567","article-title":"Higher triglyceride\u2013glucose index is associated with increased likelihood of kidney stones","volume":"12","author":"Qin","year":"2021","journal-title":"Front Endocrinol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12904","article-title":"Triglyceride-Glucose Index (TyG) is associated with erectile dysfunction: A cross-sectional study","volume":"9","author":"Yilmaz","year":"2021","journal-title":"Andrology"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1448359","article-title":"Association between TyG index and risk of carotid atherosclerosis in NAFLD patients: a retrospective cohort study","volume":"15","author":"Huang","year":"2024","journal-title":"Front Endocrinol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17912","article-title":"Menopausal stages and overactive bladder symptoms in middle-aged women: A cross-sectional study","volume":"131","author":"Park","year":"2024","journal-title":"BJOG: Int J Obstet Gynaecol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1400398","article-title":"Association of healthy eating index-2015 and overactive bladder: a cross-sectional study","volume":"11","author":"Hao","year":"2024","journal-title":"Front Nutr"},{"key":"B20","doi-asserted-by":"publisher","first-page":"3","DOI":"10.5213\/inj.2142188.094","article-title":"Oxidative stress biomarkers in age-related lower urinary tract disorders: A systematic review","volume":"26","author":"Khosla","year":"2022","journal-title":"Int Neurourol J"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.5213\/inj.1632508.254","article-title":"Association between overactive bladder and polyneuropathy in diabetic patients","volume":"20","author":"Tanik","year":"2016","journal-title":"Int Neurourol J"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1386639","article-title":"Diabetes mellitus, systemic inflammation and overactive bladder","volume":"15","author":"He","year":"2024","journal-title":"Front Endocrinol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00063.2017","article-title":"Mechanisms of insulin action and insulin resistance","volume":"98","author":"Petersen","year":"2018","journal-title":"Physiol Rev"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1210\/en.2016-1218","article-title":"Estrogens exacerbate nociceptive pain via up-regulation of TRPV1 and ANO1 in trigeminal primary neurons of female rats","volume":"157","author":"Yamagata","year":"2016","journal-title":"Endocrinology"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1610140\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T04:14:37Z","timestamp":1749010477000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1610140\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,4]]},"references-count":24,"alternative-id":["10.3389\/fendo.2025.1610140"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2025.1610140","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,4]]},"article-number":"1610140"}}