{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:41:20Z","timestamp":1792932080535,"version":"4.5.0"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Endometriosis is a prevalent, estrogen-dependent, inflammatory disease that impairs fertility via hormonal dysregulation, immune dysfunction, oxidative stress\/ferroptosis, genetic and epigenetic alterations, and microbiome imbalance. We summarize multi-omics insights and clinical implications for endometriosis-associated infertility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This article is a Systematic Review that synthesizes recent multi-omics and clinical evidence on mechanisms (hormonal, immune-inflammatory, oxidative stress\/ferroptosis, genetic\/epigenetic, microbiome\/metabolic) and appraises therapeutic strategies spanning surgery, hormonal suppression, assisted reproductive technologies (ART), and emerging adjuncts. Mechanistic and clinical findings are integrated to map targets, biomarkers, and precision-care opportunities across disease phenotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Evidence indicates local estrogen dominance with progesterone resistance, pervasive immune dysregulation, and oxidative stress with iron-driven ferroptosis that particularly injures granulosa cells, alongside disease-relevant genetic\/epigenetic regulators and reproductive-tract\/gut microbiome dysbiosis. Clinically, endometriosis detrimentally affects ovarian reserve and oocyte competence, disrupts endometrial receptivity\/decidualization, and remodels pelvic anatomy through adhesions and fibrosis, cumulatively reducing fecundity. Current management includes laparoscopic excision\/ablation, hormonal suppression (e.g., progestins, GnRH analogs\/antagonists), and ART tailored to goals and disease severity. Adjunctive antioxidant and immune-modulating approaches show promise but require robust clinical validation. Biomarker discovery\u2014including epigenetic regulators and microbiome-derived signals\u2014may enable earlier diagnosis and personalization. Innovative avenues include immunotherapy targeting nociceptor\u2013immune crosstalk, ferroptosis modulation, microbiota manipulation, and diet-based metabolic strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The pathogenesis of endometriosis-associated infertility is multifactorial and interconnected. While current treatments offer benefits, their efficacy is variable. The integration of multi-omics data is unveiling novel diagnostic biomarkers and therapeutic targets. Future management requires a patient-centered, multidisciplinary precision medicine approach that combines mechanistic insights with individualized treatment strategies to improve reproductive outcomes across the disease spectrum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2025.1613334","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T04:20:43Z","timestamp":1759378843000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":41,"title":["Endometriosis-associated infertility: Multi-omics insights into pathogenesis and precision therapeutics"],"prefix":"10.3389","volume":"16","author":[{"given":"Yuyi","family":"Ou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cankun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minqing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e070750","DOI":"10.1136\/bmj-2022-070750","article-title":"Pathophysiology, diagnosis, and management of endometriosis","volume":"379","author":"Horne","year":"2022","journal-title":"BMJ"},{"key":"B2","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1093\/humupd\/dmz012","article-title":"Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis","volume":"25","author":"Horton","year":"2019","journal-title":"Hum Reprod Update"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2021.1975675","article-title":"Long-term trends in the incidence of endometriosis in China from 1990 to 2019: a joinpoint and age-period-cohort analysis","volume":"37","author":"Feng","year":"2021","journal-title":"Gynecol Endocrinol: Off J Int Soc Gynecol Endocrinol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/nyas.14468","article-title":"Global, regional, and national endometriosis trends from 1990 to 2017","volume":"1484","author":"Zhang","year":"2021","journal-title":"Ann N Y Acad Sci"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurox.2024.100363","article-title":"Global, regional, and national prevalence and disability-adjusted life-years for endometriosis in 204 countries and territories, 1990-2019: findings from a global burden of disease study","volume":"25","author":"Shen","year":"2025","journal-title":"Eur J Obstet Gynecol Reprod Biol: X"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-021-09666-w","article-title":"Hormonal treatments for endometriosis: the endocrine background","volume":"23","author":"Vannuccini","year":"2022","journal-title":"Rev Endocr Metab Disord"},{"key":"B7","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1093\/humupd\/dmab035","article-title":"The role of gut and genital microbiota and the estrobolome in endometriosis, infertility and chronic pelvic pain","volume":"28","author":"Salliss","year":"2021","journal-title":"Hum Reprod Update"},{"key":"B8","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1186\/s12967-024-05245-0","article-title":"Multi-omics integration highlights the role of ubiquitination in endometriosis fibrosis","volume":"22","author":"Yang","year":"2024","journal-title":"J Transl Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"6162","DOI":"10.3390\/ijerph19106162","article-title":"Endometriosis and infertility: a long-life approach to preserve reproductive integrity","volume":"19","author":"Coccia","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.02.093","article-title":"Pathogenic mechanisms in endometriosis-associated infertility","volume":"90","author":"Gupta","year":"2008","journal-title":"Fertil Steril"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13082","article-title":"Endometriosis-associated infertility: aspects of pathophysiological mechanisms and treatment options","volume":"96","author":"Tanbo","year":"2017","journal-title":"Acta Obstet Gynecol Scand"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011031.pub3","article-title":"Laparoscopic surgery for endometriosis","volume":"2020","author":"Bafort","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1020827","article-title":"Endometriosis-associated infertility: From pathophysiology to tailored treatment","volume":"13","author":"Bonavina","year":"2022","journal-title":"Front Endocrinol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1093\/humupd\/dmz034","article-title":"Polymorphisms and endometriosis: a systematic review and meta-analyses","volume":"26","author":"M\u00e9ar","year":"2020","journal-title":"Hum Reprod Update"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1159\/000541615","article-title":"Oocyte quality in women with endometriosis","volume":"90","author":"Trinchant","year":"2025","journal-title":"Gynecol Obstet Invest"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e23130","DOI":"10.1096\/fj.202300907","article-title":"Endometriosis in the era of precision medicine and impact on sexual and reproductive health across the lifespan and in diverse populations","volume":"37","author":"Giudice","year":"2023","journal-title":"FASEB J: Off Publ Fed Am Soc Exp Biol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000000808","article-title":"Adolescent endometriosis","volume":"75","author":"Gubbels","year":"2020","journal-title":"Obstet Gynecol Surv"},{"key":"B18","doi-asserted-by":"publisher","first-page":"CD003678","DOI":"10.1002\/14651858.CD003678.pub3","article-title":"Pre- and postsurgical medical therapy for endometriosis surgery","volume":"2020","author":"Chen","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.35128","article-title":"Cyclooxygenase-2 in endometriosis","volume":"15","author":"Lai","year":"2019","journal-title":"Int J Biol Sci"},{"key":"B20","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1093\/humupd\/dmz049","article-title":"Diagnosing adenomyosis: an integrated clinical and imaging approach","volume":"26","author":"Chapron","year":"2020","journal-title":"Hum Reprod Update"},{"key":"B21","doi-asserted-by":"publisher","first-page":"eadk8230","DOI":"10.1126\/scitranslmed.adk8230","article-title":"Nociceptor-to-macrophage communication through CGRP\/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice","volume":"16","author":"Fattori","year":"2024","journal-title":"Sci Transl Med"},{"key":"B22","doi-asserted-by":"publisher","first-page":"7503","DOI":"10.3390\/ijms24087503","article-title":"A lifelong impact on endometriosis: pathophysiology and pharmacological treatment","volume":"24","author":"Chen","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/frph.2023.1130849","article-title":"Macrophages and small extracellular vesicle mediated-intracellular communication in the peritoneal microenvironment: impact on endometriosis development","volume":"5","author":"Wang","year":"2023","journal-title":"Front Reprod Health"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1128301","article-title":"Immunotherapy: a promising novel endometriosis therapy","volume":"14","author":"Li","year":"2023","journal-title":"Front Immunol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2024.104415","article-title":"Peri-implantation treatment with TNF-\u03b1 inhibitor for endometriosis and\/or adenomyosis women undergoing frozen-thawed embryo transfer: a retrospective cohort study","volume":"167","author":"Liu","year":"2025","journal-title":"J Reprod Immunol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231810902","article-title":"CTLA4-linked autoimmunity in the pathogenesis of endometriosis and related infertility: a systematic review","volume":"23","author":"Miku\u0161","year":"2022","journal-title":"IJMS"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S417430","article-title":"Autoimmune disease-related hub genes are potential biomarkers and associated with immune microenvironment in endometriosis","volume":"16","author":"Yang","year":"2023","journal-title":"Int J Gen Med"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.3390\/cells10112857","article-title":"Management of rheumatoid arthritis: an overview","volume":"10","author":"Radu","year":"2021","journal-title":"Cells"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2010.0446","article-title":"The diagnosis and treatment of deep infiltrating endometriosis","volume":"107","author":"Halis","year":"2010","journal-title":"Dtsch Arztebl Int"},{"key":"B30","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1186\/s13048-024-01508-y","article-title":"Research progress of ferroptosis in female infertility","volume":"17","author":"Peiyin","year":"2024","journal-title":"J Ovarian Res"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17921","article-title":"Digestive system deep infiltrating endometriosis: what do we know","volume":"27","author":"Yin","year":"2023","journal-title":"J Cell Mol Med"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122370","article-title":"Spotlight on iron overload and ferroptosis: research progress in female infertility","volume":"340","author":"Zhang","year":"2024","journal-title":"Life Sci"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043809","article-title":"Oxidative stress as a potential underlying cause of minimal and mild endometriosis-related infertility","volume":"24","author":"Didziokaite","year":"2023","journal-title":"IJMS"},{"key":"B34","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/s41420-023-01606-8","article-title":"Double-edged roles of ferroptosis in endometriosis and endometriosis-related infertility","volume":"9","author":"Li","year":"2023","journal-title":"Cell Death Discov"},{"key":"B35","doi-asserted-by":"publisher","first-page":"e21209","DOI":"10.1096\/fj.202002178R","article-title":"Endometrial epithelial ARID1A is critical for uterine gland function in early pregnancy establishment","volume":"35","author":"Marquardt","year":"2021","journal-title":"FASEB J: Off Publ Fed Am Soc Exp Biol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-024-01739-8","article-title":"Efficacy and safety of a novel pain management device, AT-04, for endometriosis-related pain: study protocol for a phase III randomized controlled trial","volume":"21","author":"Ishikawa","year":"2024","journal-title":"Reprod Health"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1372221","article-title":"Identification of programmed cell death-related genes and diagnostic biomarkers in endometriosis using a machine learning and mendelian randomization approach","volume":"15","author":"Xie","year":"2024","journal-title":"Front Endocrinol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnad020","article-title":"Epigenetic dysregulation in endometriosis: implications for pathophysiology and therapeutics","volume":"44","author":"Marquardt","year":"2023","journal-title":"Endocr Rev"},{"key":"B39","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1093\/humupd\/dmac027","article-title":"BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis","volume":"28","author":"Louwen","year":"2022","journal-title":"Hum Reprod Update"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-021-02247-5","article-title":"The impact of the female genital tract microbiome in women health and reproduction: a review","volume":"38","author":"Punz\u00f3n-Jim\u00e9nez","year":"2021","journal-title":"J Assist Reprod Genet"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115644","article-title":"Intricate connections between the microbiota and endometriosis","volume":"22","author":"Jiang","year":"2021","journal-title":"IJMS"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1328419","article-title":"Unraveling the microbial puzzle: exploring the intricate role of gut microbiota in endometriosis pathogenesis","volume":"14","author":"Tang","year":"2024","journal-title":"Front Cell Infect Microbiol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12958-020-0567-7","article-title":"Smoke, alcohol and drug addiction and female fertility","volume":"18","author":"De Angelis","year":"2020","journal-title":"Reprod Biol Endocrinol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000464","article-title":"Endometrioma, fertility, and assisted reproductive treatments: connecting the dots","volume":"30","author":"Cecchino","year":"2018","journal-title":"Curr Opin Obstet Gynecol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13111926","article-title":"Current understanding of and future directions for endometriosis-related infertility research with a focus on ferroptosis","volume":"13","author":"Kobayashi","year":"2023","journal-title":"Diagnostics"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.11.021","article-title":"Ovarian stimulation and endometriosis progression or recurrence: a systematic review","volume":"38","author":"Somigliana","year":"2019","journal-title":"Reprod BioMed Online"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60081358","article-title":"Endometriosis and In vitro fertilization","volume":"60","author":"Latif","year":"2024","journal-title":"Med (Mex)"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-022-02460-w","article-title":"Association of embryo transfer type with infertility in endometriosis: a systematic review and meta-analysis","volume":"39","author":"Chang","year":"2022","journal-title":"J Assist Reprod Genet"},{"key":"B49","doi-asserted-by":"publisher","first-page":"e1564","DOI":"10.1002\/ctm2.1564","article-title":"The involvement of RNA N6-methyladenosine and histone methylation modification in decidualization and endometriosis-associated infertility","volume":"14","author":"Lin","year":"2024","journal-title":"Clin Transl Med"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmad031","article-title":"Roles of bone morphogenetic proteins in endometrial remodeling during the human menstrual cycle and pregnancy","volume":"30","author":"Wei","year":"2024","journal-title":"Hum Reprod Update"},{"key":"B51","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s00281-025-01040-1","article-title":"Perturbations of the endometrial immune\u00a0microenvironment in endometriosis and adenomyosis: their impact on reproduction and pregnancy","volume":"47","author":"Shi","year":"2025","journal-title":"Semin Immunopathol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.58657","article-title":"Protopanaxadiol improves endometriosis associated infertility and miscarriage in sex hormones receptors-dependent and independent manners","volume":"17","author":"Lai","year":"2021","journal-title":"Int J Biol Sci"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2023.102432","article-title":"Endometriosis and adenomyosis: similarities and differences","volume":"92","author":"Donnez","year":"2024","journal-title":"Best Pract Res Clin Obstetr Gynaecol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2018.07.017","article-title":"Endometriosis revisited: an imaging review of the usual and unusual manifestations with pathological correlation","volume":"52","author":"Tran-Harding","year":"2018","journal-title":"Clin Imaging"},{"key":"B55","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.fertnstert.2019.09.031","article-title":"Interventions for endometriosis-related infertility: a systematic review and network meta-analysis","volume":"113","author":"Hodgson","year":"2020","journal-title":"Fertil Steril"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.10.019","article-title":"Which treatments are effective for endometriosis-related infertility","volume":"113","author":"Vercellini","year":"2020","journal-title":"Fertil Steril"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.31031\/PRM.2020.03.000570","article-title":"How can we optimize the granulose cell function of oocytes from an endometriosis patient to improve the reproductive outcomes-a short communication","volume":"3","author":"Kochar Kaur","year":"2020","journal-title":"Percept Reprod Med"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dead093.689","article-title":"P-331 transcriptomic profiling of ovaries with experimental endometrioma in mice reveals the underlying mechanisms of abnormal oocyte quality and functions in endometrioma-associated infertility","volume":"38","author":"Tan","year":"2023","journal-title":"Hum Reprod"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1226687","article-title":"Decreased oocyte quality in patients with endometriosis is closely related to abnormal granulosa cells","volume":"14","author":"Fan","year":"2023","journal-title":"Front Endocrinol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2024.102723","article-title":"Discoid excision for colorectal endometriosis associated infertility: a balance between fertility outcomes and complication rates","volume":"53","author":"Dabi","year":"2024","journal-title":"J Gynecol Obstet Hum Reprod"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2022.2117155","article-title":"Novel pharmacological therapies for the treatment of endometriosis","volume":"15","author":"Buggio","year":"2022","journal-title":"Expert Rev Clin Pharmacol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2024.03.026","article-title":"Fertility drugs and cancer: a guideline","volume":"122","year":"2024","journal-title":"Fertil Steril"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoac025","article-title":"Endometriosis and oocyte quality: an analysis of 13\u200a614 donor oocyte recipient and autologous IVF cycles","volume":"2022","author":"Kamath","year":"2022","journal-title":"Hum Reprod Open"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.11.014","article-title":"Top 10 priorities for future infertility research: an international consensus development study","volume":"115","author":"Duffy","year":"2021","journal-title":"Fertil Steril"},{"key":"B65","doi-asserted-by":"publisher","first-page":"CD007677","DOI":"10.1002\/14651858.CD007677.pub4","article-title":"Pentoxifylline for the treatment of endometriosis-associated pain and infertility","volume":"2021","author":"Grammatis","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22042165","article-title":"Exosomes as biomarkers for female reproductive diseases diagnosis and therapy","volume":"22","author":"Esfandyari","year":"2021","journal-title":"IJMS"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101476","article-title":"Pyroptotic T cell-derived active IL-16 has a driving function in ovarian endometriosis development","volume":"5","author":"Zhang","year":"2024","journal-title":"Cell Rep Med"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2025.103752","article-title":"Endometriosis and autoimmunity","volume":"24","author":"Blanco","year":"2025","journal-title":"Autoimmun Rev"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.944683","article-title":"Bioinformatics identification and validation of biomarkers and infiltrating immune cells in endometriosis","volume":"13","author":"Jiang","year":"2022","journal-title":"Front Immunol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1186\/s12916-023-02881-z","article-title":"The effects of coagulation factors on the risk of endometriosis: a mendelian randomization study","volume":"21","author":"Li","year":"2023","journal-title":"BMC Med"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1601398","article-title":"Biomarkers of pelvic endometriosis","volume":"39","author":"Reis","year":"2017","journal-title":"Rev Bras Ginecol Obstet: Rev Fed Bras Soc Ginecol Obstet"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3390\/nu15092131","article-title":"Adherence to the Mediterranean diet in women and reproductive health across the lifespan: a narrative review","volume":"15","author":"Szmidt","year":"2023","journal-title":"Nutrients"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.06.004","article-title":"Menstruation: science and society","volume":"223","author":"Critchley","year":"2020","journal-title":"Am J Obstet Gynecol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1613334\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T04:20:43Z","timestamp":1759378843000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1613334\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,2]]},"references-count":73,"alternative-id":["10.3389\/fendo.2025.1613334"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2025.1613334","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,2]]},"article-number":"1613334"}}