{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:11:41Z","timestamp":1777554701813,"version":"3.51.4"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the study was to compare neuroendocrine dysfunction patterns in adult-onset adamantinomatous craniopharyngiomas (ACPs) and papillary craniopharyngiomas (PCPs) before and after surgery, and identify factors that influence neuroendocrine outcomes in these two histopathological types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted on 390 patients with adult-onset craniopharyngioma (CP) patients, including 272 patients with ACP and 118 patients with PCP. The pre- and post-operative neuroendocrine parameters were compared, and the factors that contributed to poor endocrine outcomes were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Suprasellar tumor extension (83.1% <jats:italic>vs.<\/jats:italic> 70.6%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01), mass effects (81.4% <jats:italic>vs.<\/jats:italic> 68.4%, <jats:italic>p<\/jats:italic>&amp;lt;0.01), and pre-operative central diabetes insipidus (CDI; 35.6% <jats:italic>vs.<\/jats:italic> 21.0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02) rates were higher in the PCP group, when compared to the ACP group. However, both PCP and ACP patients presented with a post-operative increase in growth hormone deficiency (GHD), CDI, and hypothalamic-pituitary-target dysfunction (<jats:italic>p<\/jats:italic>&amp;lt;0.05 <jats:italic>vs.<\/jats:italic> pre-operative baselines). Furthermore, the hypothalamic-pituitary-adrenal (HPA) axis dysfunction (75.4% <jats:italic>vs.<\/jats:italic> 65.3%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04) and GHD (50.0% <jats:italic>vs.<\/jats:italic> 34.7%, <jats:italic>p<\/jats:italic>&amp;lt;0.01) rates were higher in the ACP group, when compared to the PCP group. Surgical intervention had a greater detrimental effect on overall pituitary function in ACP patients, when compared to PCP patients. The ACP pathological type, larger tumors, and milder pre-operative endocrine dysfunction were associated with a significantly higher risk of postoperative pituitary hormone deficiencies (<jats:italic>p<\/jats:italic>&amp;lt;0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Surgical intervention may exacerbate pituitary dysfunction in adult patients with ACP and PCP, although different factors influence the adverse endocrine outcomes for these two pathological types.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1615720","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T04:12:44Z","timestamp":1757909564000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Characteristics and influencing factors of neuroendocrine dysfunction in patients with adult-onset 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