{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:23:06Z","timestamp":1782944586250,"version":"3.54.5"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>This meta-analysis and data mining aimed to investigate the effectiveness of Acupuncture-Related Therapies for animal models with Postmenopausal Osteoporosis (POMP) and to summarize the acupoints involved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This systematic review was conducted a comprehensive search of animal experiments using acupuncture-related therapies for the treatment of PMOP up to April 1, 2025. The primary outcome was bone mineral density (BMD). The secondary outcome indicators were estradiol(E<jats:sub>2<\/jats:sub>), blood calcium, osteocalcin(OC) and alkaline phosphatas(ALP).Meta-analysis was used to evaluate its efficacy, and data mining was used to explore the protocol for acupoint selection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>27 Animal Experiments encompassing 548 animals with PMOP were analyzed. Meta-analysis displayed that compared with the conventional drug group, the acupuncture-related therapy group significantly increased the Estradiol (mean difference [MD] 2.37,95% confidence interval [95%CI] 1.15 to 3.58), Femoral BMD (mean difference [MD] 1.25,95% confidence interval [95%CI] 0.65 to 1.87), lumbar BMD (mean difference [MD] 1.88,95% confidence interval [95%CI] 1.27 to 2.49), Tibia BMD (mean difference [MD] 1.63,95% confidence interval [95%CI] 0.56 to 2.69). Data mining revealed that Zusanli (ST36), Shenshu (BL23), Guanyuan (CV4), and Sanyinjiao (SP6) were the core acupoints for PMOP treated by Acupuncture-Related Therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Acupuncture improved BMD and estrogen levels in animal models of PMOP. ST36, BL23, CV4, and SP6 are the core acupoints for acupuncture in PMOP, and this program is expected to become a supplementary treatment for PMOP.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1617154","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T04:24:27Z","timestamp":1760502267000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The effect of acupuncture-related therapies in animal model of postmenopausal osteoporosis: a meta-analysis and data mining approach"],"prefix":"10.3389","volume":"16","author":[{"given":"Guangbin","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YingYing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyuan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guizhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.965258","article-title":"Immunoporosis: role of immune system in the pathophysiology of different types of osteoporosis","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22042105","article-title":"Osteoporosis in men: a review of an underestimated bone condition","volume":"22","author":"Rinonapoli","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2022.09.007","article-title":"Acr appropriateness criteria(r) osteoporosis and bone mineral density: 2022 update","volume":"19","author":"Yu","year":"2022","journal-title":"J Am Coll Radiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.reuma.2019.04.001","article-title":"Severe osteoporosis: principles for pharmacological therapy in Mexico","volume":"17","author":"Clark","year":"2021","journal-title":"Reumatol Clin (Engl Ed)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/s40001-025-02412-x","article-title":"Vitamin d and calcium supplementation in women undergoing pharmacological management for postmenopausal osteoporosis: a level i of evidence systematic review","volume":"30","author":"Migliorini","year":"2025","journal-title":"Eur J Med Res"},{"key":"B6","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/BF02210681","article-title":"Role of calcium and vitamin d in the prevention and the treatment of postmenopausal osteoporosis: an overview","author":"Kaufman","year":"1995","journal-title":"Clin Rheumatol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/med.22081","article-title":"Estrogen deficiency-mediated osteoimmunity in postmenopausal osteoporosis","volume":"45","author":"Yao","year":"2025","journal-title":"Med Res Rev"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2024.117325","article-title":"Multiple vertebral fractures after antiosteoporotic medications discontinuation: a comparative study to evaluate the potential rebound effect of denosumab","volume":"190","author":"Martin-Perez","year":"2025","journal-title":"Bone"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2019.07.010","article-title":"Rebound-associated vertebral fractures after stopping denosumab: report of four cases","volume":"87","author":"Dupont","year":"2020","journal-title":"Joint Bone Spine"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.813748","article-title":"Anti-inflammatory effects of acupuncture at st36 point: a literature review in animal studies","volume":"12","author":"Oh","year":"2021","journal-title":"Front Immunol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.878463","article-title":"The effect of acupuncture on modulating inflammatory cytokines in rodent animal models of respiratory disease: a systematic review and meta-analysis","volume":"13","author":"Lee","year":"2022","journal-title":"Front Immunol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.676827","article-title":"Acupuncture-related therapies for parkinson\u2019s disease: a meta-analysis and qualitative review","volume":"13","author":"Wen","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.1067329","article-title":"Acupuncture and related therapies for the anxiety and depression in irritable bowel syndrome with diarrhea (ibs-d): a network meta-analysis of randomized controlled trials","volume":"13","author":"Wang","year":"2022","journal-title":"Front Psychiatry"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnss.2017.06.005","article-title":"Traditional chinese medicine and nursing care","volume":"4","author":"Hao","year":"2017","journal-title":"Int J Nurs Sci"},{"key":"B15","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1186\/s12906-024-04603-1","article-title":"Acupuncture-related interventions improve chemotherapy-induced peripheral neuropathy: a systematic review and network meta-analysis","volume":"24","author":"Yeh","year":"2024","journal-title":"BMC Complement Med Ther"},{"key":"B16","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s11657-016-0288-x","article-title":"Effects of acupuncture on quality of life and pain in patients with osteoporosis-a pilot randomized controlled trial","volume":"11","author":"Schiller","year":"2016","journal-title":"Arch Osteoporos"},{"key":"B17","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/GME.0000000000002503","article-title":"Effect of laser acupuncture on pain and density of bone in osteoporotic\u2002postmenopausal\u2002women: a randomized controlled trial","volume":"32","author":"Hassan","year":"2025","journal-title":"Menopause- J Menopause Soc"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1394537","article-title":"The efficacy and safety of gukang capsule for primary osteoporosis: a systematic review and meta-analysis of randomized clinical trial","volume":"15","author":"Wei","year":"2024","journal-title":"Front Pharmacol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2020-001676","article-title":"Animal models of ischemic limb ulcers: a systematic review and meta-analysis","volume":"8","author":"Thanigaimani","year":"2020","journal-title":"BMJ Open Diabetes Res Care"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/ame2.12350","article-title":"Optimizing diabetic kidney disease animal models: insights from a meta-analytic approach","volume":"6","author":"Li","year":"2023","journal-title":"Anim Model Exp Med"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-020-09960-w","article-title":"The transverse aortic constriction heart failure animal model: a systematic review and meta-analysis","volume":"26","author":"Bosch","year":"2021","journal-title":"Heart Fail Rev"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1051\/rnd:19940305","article-title":"Animal-models for postmenopausal osteoporosis","volume":"34","author":"Barlet","year":"1994","journal-title":"Reprod Nutr Dev"},{"key":"B23","article-title":"Microrna expression profiling in an ovariectomized rat model of postmenopausal osteoporosis before and after estrogen treatment","volume":"12","author":"Xu","year":"2020","journal-title":"Am J Transl Res"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1515\/cclm.1991.29.4.211","article-title":"In vivo models in the study of osteopenias","volume":"29","author":"Cesnjaj","year":"1991","journal-title":"Eur J Clin Chem Clin Biochem"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.03.028","article-title":"Animal models for osteoporosis","volume":"759","author":"Komori","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afab177","article-title":"Relationship between fried\u2019s frailty phenotype and oral frailty in long-term care residents","volume":"50","author":"Hiltunen","year":"2021","journal-title":"Age Ageing"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The prisma 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"Bmj"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1713886","article-title":"Management of orthostatic hypotension, postprandial hypotension, and supine hypertension","volume":"40","author":"Shibao","year":"2020","journal-title":"Semin Neurol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1142\/S0192415X07004655","article-title":"Beta-blocker and other analogous treatments that affect bone mass and sympathetic nerve activity in ovariectomized rats","volume":"35","author":"Zhang","year":"2007","journal-title":"Am J Chin Med"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3727\/036012921X16281724938230","article-title":"Effect of acupoint catgut embedding on intestinal flora in rats with ovariectomized osteoporosis","volume":"46","author":"Shi","year":"2021","journal-title":"Acupuncture Electro-Therapeutics Res"},{"key":"B31","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.jtcm.2018.02.004","article-title":"Effect of acupuncture at acupoint of shenshu (bl 23) on the bones of ovariectomized rats","volume":"38","author":"Atsushi","year":"2018","journal-title":"J Tradit Chin Med"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/os.12427","article-title":"Effects of acupoint application therapy with tiangui powder on osteoporosis in ovariectomized rats through tgf-beta1 and smad2\/3 signaling pathway","volume":"11","author":"Lin","year":"2019","journal-title":"Orthop Surg"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2014-010743","article-title":"Effects of electroacupuncture at gb points on markers of osteoporosis and bodyweight in ovariectomised rats","volume":"33","author":"Wang","year":"2015","journal-title":"Acupunct Med"},{"key":"B34","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1136\/acupmed-2012-010271","article-title":"Effects of electroacupuncture on bone mineral density, oestradiol level and osteoprotegerin ligand expression in ovariectomised rabbits","volume":"32","author":"He","year":"2014","journal-title":"Acupunct Med"},{"key":"B35","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1136\/acupmed-2011-010114","article-title":"Electroacupuncture prevents ovariectomy-induced osteoporosis in rats: a randomised controlled trial","volume":"30","author":"Zhou","year":"2012","journal-title":"Acupunct Med"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X08006326","article-title":"Electroacupuncture promotes insulin-like growth factors system in ovariectomized osteoporosis rats","volume":"36","author":"Feng","year":"2008","journal-title":"Am J Chin Med"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.4849","article-title":"Electroacupuncture stimulation at cv4 prevents ovariectomy-induced osteoporosis in rats via wnt-beta-catenin signaling","volume":"13","author":"Fan","year":"2016","journal-title":"Mol Med Rep"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2016-011268","article-title":"Long-term electroacupuncture stimulation prevents osteoporosis in ovariectomised osteopaenic rats through multiple signalling pathways","volume":"36","author":"Zheng","year":"2018","journal-title":"Acupunct Med"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.16466\/j.issn1005-5509.2011.06.014","article-title":"Influence of ele-acupunctureon serum E2 and bone density of rats with menopause osteoporosis","volume":"35","author":"Pan","year":"2011","journal-title":"J Zhejiang Chin Med Univ"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.13460\/j.issn.1005-0957.2022.06.0610","article-title":"Effect of electroacupuncture on the expression of vitamin D membrane-associated rapid response steroid-binding protein in intestinal mucosa of postmenopausal osteoporosis rats","volume":"41","author":"Shi","year":"2022","journal-title":"Shanghai J Acupuncture Moxibustion"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.13702\/j.1000-0607.170591","article-title":"Electroacupuncture intervention improves cartilage degeneration and subchondral bone osteoporosis of knee-joint possibly by adjusting opg\/rank\/rankl signaling in ovariectomized rats","volume":"43","author":"Sun","year":"2018","journal-title":"Zhen Ci Yan Jiu"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.13703\/j.0255-2930.2012.12.022","article-title":"Effect of electroacupuncture on the biochemical indices of bone and bone collagen metabolism and tnf-alpha in osteoporosis model rats without ovaries","volume":"32","author":"Bao","year":"2012","journal-title":"Zhongguo Zhen Jiu"},{"key":"B43","article-title":"Effect of Electroacupuncture at Mingmen Acupoint on the Expression of Estrogen Receptor ER\u03b1 mRNA in the Adrenal Glands of Castrated Osteoporotic Model Rats","volume":"25","author":"Li","year":"2014","journal-title":"Shizhen J Traditional Chin Med Materia Med"},{"key":"B44","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3969\/j.issn.0411-8421.2003.07.022","article-title":"Exploration of the mechanism of electroacupuncture based prevention and treatment of osteoporosis","author":"Jin","year":"2003","journal-title":"Zhejiang J Traditional Chin Med"},{"key":"B45","doi-asserted-by":"publisher","first-page":"73","DOI":"10.19917\/j.cnki.1005-0779.024077","article-title":"Mechanism of EA intervention on osteoporosis in ovariectomized rats based on metabolomics","volume":"40","author":"Qu","year":"2024","journal-title":"J Clin Acupuncture"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3969\/j.issn.1006-7108.2024.01.001","article-title":"Effect of transcutaneous electrical acupoint stimulation on the balance of serum bone metabolic indexes in ovariectomized rats","volume":"30","author":"Zheng","year":"2024","journal-title":"Chin J Osteoporosis"},{"key":"B47","article-title":"Correlation between muscle, fat, estradiol levels and bone mineral density and regulation of acupuncture at tonifying kidney and invigorating spleen in ovariectomized rats","volume":"35","author":"Yuan","year":"2020","journal-title":"China J Chin Materia Med"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.13192\/j.issn.1000-1719.2019.03.053","article-title":"Mutual promotion effect and molecular mechanism of kidney shu - mu combination by thread embedding therapy on inhibiting bone loss in ovariectomized rats","volume":"46","author":"Liu","year":"2019","journal-title":"Liaoning J Traditional Chin Med"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1006-7108.2021.08.009","article-title":"Effect of TGF-pl\/Smad4 signaling pathway on bone marrow microenvironment in ovariectomized osteoporosis rats and mechanism of acupuncture intervention","volume":"27","author":"Bai","year":"2021","journal-title":"Chin J Osteoporosis"},{"key":"B50","first-page":"39","article-title":"Effect of acupoint catgut embedding on BMD,BMSCs, ALP and TGF-\u03b2 in castrated osteoporosis rats","volume":"18","author":"Chen","year":"2022","journal-title":"Asia-Pacific Traditional Med"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1003-9198.2022.02.006","article-title":"Effect of acupuncture intervention on intestinal microflora of postmenopausal osteoporosis model rats","volume":"36","author":"Zhang","year":"2022","journal-title":"Pract Geriatrics"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.13913\/j.cnki.41-1110\/r.2020.03.026","article-title":"Effects of acupuncture and point injection on reproductive endocrine in osteoporosis model rats","volume":"35","author":"Zhang","year":"2020","journal-title":"Forum Traditional Chin Med"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1672-2779.2019.01.043","article-title":"The effect of acupuncture at shenshu (BL23) and zusanli (ST36) in the treatment of postmenopausal osteoporosis rat model","volume":"17","author":"Li","year":"2019","journal-title":"Chin Med Modern Distance Educ China"},{"key":"B54","article-title":"Effect of acupuncture on bone mineral density and bone metabolism in postmenopausal osteoporotic fracture rats through Wnt signaling pathway","volume":"29","author":"Guo","year":"2023","journal-title":"Chin J Osteoporosis"},{"key":"B55","article-title":"Effects of Zuogui Pills combining mild\u2014warm moxibustion on OPG\/RANKL of osteoporosis model rats","volume":"33","author":"Qian","year":"2018","journal-title":"China J Chin Materia Med"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.19852\/j.cnki.jtcm.20230904.006","article-title":"Identifying the effective combination of acupuncture and traditional chinese medicinal herbs for postmenopausal osteoporosis therapy through studies of their molecular regulation of bone homeostasis","volume":"44","author":"Ping","year":"2024","journal-title":"J Tradit Chin Med"},{"key":"B57","doi-asserted-by":"publisher","first-page":"20220759","DOI":"10.1515\/biol-2022-0759","article-title":"Role of menopausal hormone therapy in the prevention of postmenopausal osteoporosis","volume":"18","author":"Na","year":"2023","journal-title":"Open Life Sci"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-020-05497-8","article-title":"Is there a role for menopausal hormone therapy in the management of postmenopausal osteoporosis","volume":"31","author":"Rozenberg","year":"2020","journal-title":"Osteoporos Int"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-23-0116","article-title":"Postmenopausal osteoporosis coexisting with sarcopenia: the role and mechanisms of estrogen","volume":"259","author":"Lu","year":"2023","journal-title":"J Endocrinol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1136\/aim.2011.004085","article-title":"Acupuncture for hot flushes in perimenopausal and postmenopausal women: a randomised, sham-controlled trial","volume":"29","author":"Kim","year":"2011","journal-title":"Acupunct Med"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001268","article-title":"Acupuncture to reduce sleep disturbances in perimenopausal and postmenopausal women: a systematic review and meta-analysis","volume":"127","author":"Chiu","year":"2016","journal-title":"Obstet Gynecol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1177\/09645284211056655","article-title":"Effect of acupuncture on menopausal hot flushes and serum hormone levels: a systematic review and meta-analysis","volume":"40","author":"Liu","year":"2022","journal-title":"Acupunct Med"},{"key":"B63","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s00198-023-06925-1","article-title":"Bone density and fracture risk factors in ankylosing spondylitis: a meta-analysis","volume":"35","author":"Yan","year":"2024","journal-title":"Osteoporos Int"},{"key":"B64","article-title":"Comparison of femoral nerve block and acupuncture analgesia for acute preoperative pain in elderly patients with femoral neck fracture: a retrospective study","volume":"14","author":"Lu","year":"2022","journal-title":"Am J Transl Res"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002892","article-title":"Local analgesia of electroacupuncture is mediated by the recruitment of neutrophils and released beta-endorphins","volume":"164","author":"Shi","year":"2023","journal-title":"Pain"},{"key":"B66","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3831\/KPI.2015.18.009","article-title":"Acupuncture in patients with a vertebral compression fracture: a protocol for a randomized, controlled, pilot clinical trial","volume":"18","author":"Lee","year":"2015","journal-title":"J Pharmacopuncture"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1242640","article-title":"Revealing the biological mechanism of acupuncture in alleviating excessive inflammatory responses and organ damage in sepsis: a systematic review","volume":"14","author":"Yang","year":"2023","journal-title":"Front Immunol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-019-01040-y","article-title":"Electroacupuncture pretreatment elicits neuroprotection against cerebral ischemia-reperfusion injury in rats associated with transient receptor potential vanilloid 1-mediated anti-oxidant stress and anti-inflammation","volume":"42","author":"Long","year":"2019","journal-title":"Inflammation"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111655","article-title":"Electroacupuncture facilitates m2 macrophage polarization and its potential role in the regulation of inflammatory response","volume":"140","author":"Wang","year":"2021","journal-title":"BioMed Pharmacother"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-017-0578-5","article-title":"Electro-acupuncture at zusanli acupoint (st36) suppresses inflammation in allergic contact dermatitis via triggering local il-10 production and inhibiting p38 mapk activation","volume":"40","author":"Wang","year":"2017","journal-title":"Inflammation"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1159\/000214845","article-title":"Changes in histomorphometric and mechanical properties of femurs induced by acupuncture at the shenshu point in the samp6 mouse model of senile osteoporosis","volume":"55","author":"Zhang","year":"2009","journal-title":"Gerontology"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6436420","article-title":"Moxibustion of zusanli (st36) and shenshu (bl23) alleviates cartilage degradation through rankl\/opg signaling in a rabbit model of rheumatoid arthritis","volume":"2019","author":"Chen","year":"2019","journal-title":"Evid Based Complement Alternat Med"},{"key":"B73","doi-asserted-by":"publisher","first-page":"207","DOI":"10.13702\/j.1000-0607.2014.03.008","article-title":"Effects of electroacupuncture stimulation at \u201cguanyuan\u201d (cv 4) on serum insulin-like growth factor-1 content and bone biomechanics in ovariectomy-induced osteoporosis rats","volume":"39","author":"Zhang","year":"2014","journal-title":"Zhen Ci Yan Jiu"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111655","article-title":"Electroacupuncture facilitates M2 macrophage polarization and its potential role in the regulation of inflammatory response","volume":"140","author":"Wang","year":"2021","journal-title":"Biomed Pharmacother"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1617154\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T04:24:38Z","timestamp":1760502278000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1617154\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,15]]},"references-count":74,"alternative-id":["10.3389\/fendo.2025.1617154"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2025.1617154","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,15]]},"article-number":"1617154"}}