{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T04:40:04Z","timestamp":1751604004144,"version":"3.41.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Ovarian endometriosis cysts are associated with infertility, and recent research increasingly focuses on improving pregnancy outcomes. Traditional Chinese medicine (TCM) has long been used for gynecological issues, yet the impact of staged TCM administration on pregnancy outcomes and Endometriosis Fertility Index (EFI) scores in infertile patients remains underexplored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to evaluate the effects of staged TCM administration on pregnancy outcomes and EFI scores in patients with ovarian endometriosis cysts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective analysis of 150 infertile patients treated with staged TCM administration was conducted. Patients received Formula I before ovulation and Formula II post-ovulation, with the cohort split into pregnancy (n=91) and non-pregnancy groups (n=49). All patients underwent laparoscopic surgery prior to TCM treatment. Logistic regression and ROC analysis were used to assess pregnancy predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant differences in age, infertility type, infertility duration, r-AFS stage, cyst diameter, and EFI score (P&amp;lt;0.05) were found. Age, secondary infertility, infertility duration (\u22653 years), advanced r-AFS stage, cyst diameter (\u22653cm), and EFI score (&amp;lt;7) were key risk factors. The EFI score\u2019s AUC for predicting pregnancy was 0.731 (95%CI, 0.617-0.844), with 72.58% sensitivity and 75.83% specificity. No significant difference in follow-up duration was observed between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Age, secondary infertility, infertility duration (\u2265 3 years), r-AFS stage (stages III and IV), cyst diameter (\u2265 3cm), and EFI score (&amp;lt; 7) were identified as risk factors for infertility in patients with ovarian endometriosis following a two-phase staged oral administration of traditional Chinese medicine. Among these factors, the EFI score can serve as a crucial evaluation index for postoperative pregnancy, assessing the likelihood of pregnancy and predicting patient prognosis.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1624925","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T04:10:39Z","timestamp":1751602239000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Logistic regression analysis of pregnancy outcome and EFI score of infertile patients with ovarian endometriosis cyst after staged oral administration of traditional Chinese medicine"],"prefix":"10.3389","volume":"16","author":[{"given":"Yali","family":"Bo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaochan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawen","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dunmin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"B1","article-title":"Clinical factors influencing the pregnancy outcome after laparoscopic treatment in endometriosis-associated infertility patients: a retrospective study","volume":"13","author":"Sindan","year":"2021","journal-title":"Am J Transl Res"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.03.018","article-title":"Association of endometriosis and adenomyosis with pregnancy and infertility","volume":"119","author":"Vercellini","year":"2023","journal-title":"Fertil Steril"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00389-5","article-title":"Endometriosis is a chronic systemic disease: clinical challenges and novel innovations","volume":"397","author":"Taylor","year":"2021","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2019.11.011","article-title":"Adolescent endometriosis: an update","volume":"33","author":"Shim","year":"2020","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1097\/AOG.0000000000005448","article-title":"Evaluation and management of endometriosis in the adolescent","volume":"143","author":"Shim","year":"2024","journal-title":"Obstet Gynecol"},{"key":"B6","article-title":"Ileal endometriosis. An uncommon cause of bowel obstruction in women in fertile age","volume":"80","author":"Gonzalez Salazar","year":"2020","journal-title":"Medicina (B Aires)"},{"key":"B7","article-title":"Clinical diagnosis and treatment guidelines","volume-title":"Obstetrics and gynecology division book","year":"2007"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1004-8189.2020.02.011","article-title":"Predictive value of endometriosis fertility index for postoperative natural pregnancy in ectopic patients [in chinese]","volume":"28","author":"Li","year":"2020","journal-title":"Chin J Family Plann"},{"key":"B9","doi-asserted-by":"publisher","first-page":"117085","DOI":"10.1016\/j.lfs.2019.117085","article-title":"Tanshinone IIA contributes to the pathogenesis of endometriosis via renin angiotensin system by regulating the dorsal root ganglion axon sprouting","volume":"240","author":"Chen","year":"2020","journal-title":"Life Sci"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-021-00813-x","article-title":"Tetramethylpyrazine retards the progression and fibrogenesis of endometriosis","volume":"29","author":"Huang","year":"2022","journal-title":"Reprod Sci"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1124\/mol.104.010082","article-title":"Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related phosphatidylinositol 3-kinase\/Akt and p38 mitogen-activated protein kinase pathways in osteoblasts","volume":"68","author":"Yen","year":"2005","journal-title":"Mol Pharmacol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/s13020-022-00694-5","article-title":"Taxillus chinensis (DC.) Danser: a comprehensive review on botany, traditional uses, phytochemistry, pharmacology, and toxicology","volume":"17","author":"Qin","year":"2022","journal-title":"Chin Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"4034","DOI":"10.3390\/molecules27134034","article-title":"Endometriosis: A disease with few direct treatment options","volume":"27","author":"Franca","year":"2022","journal-title":"Molecules"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/ases.12874","article-title":"Laparoscopic surgery in patients with cystic fibrosis: A systematic review","volume":"14","author":"El Boghdady","year":"2021","journal-title":"Asian J Endosc Surg"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-022-05319-8","article-title":"Should all minimal access surgery be robot-assisted? A systematic review into the musculoskeletal and cognitive demands of laparoscopic and robot-assisted laparoscopic surgery","volume":"26","author":"Shugaba","year":"2022","journal-title":"J Gastrointest Surg"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-022-04218-3","article-title":"Laparoscopic surgery for complex Crohn\u2019s disease: perioperative and long-term results from a propensity matched cohort","volume":"37","author":"Connelly","year":"2022","journal-title":"Int J Colorectal Dis"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.52054\/FVVO.13.4.041","article-title":"What to choose and why to use - a critical review on the clinical relevance of rASRM, EFI and Enzian classifications of endometriosis","volume":"13","author":"Hudelist","year":"2021","journal-title":"Facts Views Vis Obgyn"},{"key":"B18","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1080\/03630242.2021.1986458","article-title":"Endometriosis fertility index predicts pregnancy in women operated on for moderate and severe symptomatic endometriosis","volume":"62","author":"Rodrigues","year":"2022","journal-title":"Women Health"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.3390\/jpm12101623","article-title":"Endometriosis and infertility: prognostic value of enzian classification compared to rASRM and EFI score","volume":"12","author":"Fruscalzo","year":"2022","journal-title":"J Pers Med"},{"key":"B20","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1111\/1471-0528.16180","article-title":"Why and when you should use the endometriosis fertility index (EFI)","volume":"127","author":"Tomassetti","year":"2020","journal-title":"BJOG"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.220637","article-title":"Diagnosis and management of endometriosis","volume":"195","author":"Allaire","year":"2023","journal-title":"CMAJ"},{"key":"B22","doi-asserted-by":"publisher","first-page":"6725","DOI":"10.3390\/ijerph19116725","article-title":"New understanding of diagnosis, treatment and prevention of endometriosis","volume":"19","author":"Amro","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1080\/13697137.2021.1948994","article-title":"Endometriosis-associated cancer","volume":"24","author":"Guidozzi","year":"2021","journal-title":"Climacteric"},{"key":"B24","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.fertnstert.2022.03.015","article-title":"Infertility workup: identifying endometriosis","volume":"118","author":"Pirtea","year":"2022","journal-title":"Fertil Steril"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.05.005","article-title":"Traditional uses, botany, phytochemistry, pharmacology and toxicology of Panax notoginseng (Burk.)","volume":"188","author":"Wang","year":"2016","journal-title":"FH Chen: review. J ethnopharmacology"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1376037","article-title":"Exploring the role of Chinese herbal medicine in the long-term management of postoperative ovarian endometriotic cysts: a systematic review and meta-analysis","volume":"15","author":"Ding","year":"2024","journal-title":"Front Pharmacol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1624925\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T04:10:40Z","timestamp":1751602240000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1624925\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,4]]},"references-count":26,"alternative-id":["10.3389\/fendo.2025.1624925"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2025.1624925","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,4]]}}}