{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:46:13Z","timestamp":1780573573016,"version":"3.54.1"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004699","name":"Chung Shan Medical University Hospital","doi-asserted-by":"publisher","award":["CSH-2022-A-022"],"award-info":[{"award-number":["CSH-2022-A-022"]}],"id":[{"id":"10.13039\/501100004699","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether gestational diabetes mellitus (GDM) is associated with an increased risk of neonatal hypoglycemia and adverse neonatal outcomes in a Taiwanese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective cohort study of 2,149 women who delivered at Chung Shan Medical University Hospital from 2019 to 2023. GDM was diagnosed by one-step 75-g oral glucose tolerance test (OGTT). Neonatal hypoglycemia was defined as blood glucose &amp;lt;45 mg\/dL. Logistic regression was used to estimate odds ratios (ORs) for neonatal outcomes associated with GDM, adjusting for maternal age, body mass index (BMI), and parity. Other neonatal outcomes included preterm birth, low Apgar scores (\u22647 at 1 or 5 minutes), neonatal intensive care unit (NICU) admission, or neonatal jaundice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2,149 pregnancies, 591 (27.5%) were diagnosed with GDM. Neonatal hypoglycemia occurred in 176 newborns (8.2%). The incidence of hypoglycemia was slightly lower in infants of GDM mothers (6.8%) compared to those of non-GDM mothers (8.7%), but this difference was not statistically significant (adjusted OR 0.70, 95% CI 0.48\u20131.02). GDM was also not significantly associated with other neonatal outcomes, including preterm birth, low Apgar scores, NICU admission, or neonatal jaundice, after adjusting for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this Taiwanese cohort with universal GDM screening and management, GDM was not linked to a higher risk of neonatal hypoglycemia or other immediate neonatal complications. These findings suggest that effective prenatal care and glycemic control may mitigate the neonatal risks traditionally associated with GDM, underscoring the importance of management and population-specific factors in outcomes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1634074","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T04:11:55Z","timestamp":1756959115000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating the association between gestational diabetes and neonatal hypoglycemia in Taiwan: a retrospective study of 2,149 pregnancies"],"prefix":"10.3389","volume":"16","author":[{"given":"Shiang-Hua","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Hsiu","family":"Hsin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Juen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Sun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Chang","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Ning","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hsun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edy","family":"Kornelius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1515\/prilozi-2017-0013","article-title":"Neonatal hypoglycemia: risk factors and outcomes","volume":"38","author":"Stomnaroska","year":"2017","journal-title":"PRILOZI"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.05.022","article-title":"Incidence of neonatal hypoglycemia in babies identified as at risk","volume":"161","author":"Harris","year":"2012","journal-title":"J Pediatrics"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1159\/000492859","article-title":"Neonatal glycaemia and neurodevelopmental outcomes: A systematic review and meta-analysis","volume":"115","author":"Shah","year":"2019","journal-title":"Neonatology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.12968\/hmed.2024.0410","article-title":"Impact of gestational diabetes mellitus on neonatal birth outcomes","volume":"85","author":"Liu","year":"2024","journal-title":"Br J Hosp Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0902430","article-title":"A multicenter, randomized trial of treatment for mild gestational diabetes","volume":"361","author":"Landon","year":"2009","journal-title":"N Engl J Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00825-0","article-title":"Epidemiology and management of gestational diabetes","volume":"404","author":"Sweeting","year":"2024","journal-title":"Lancet"},{"key":"B7","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1186\/s12884-018-2005-9","article-title":"Evaluation of neonatal and maternal morbidity in mothers with gestational diabetes: a population-based study","volume":"18","author":"Domanski","year":"2018","journal-title":"BMC Pregnancy Childbirth"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-3931-6","article-title":"The fetal glucose steal: an underappreciated phenomenon in diabetic pregnancy","volume":"59","author":"Desoye","year":"2016","journal-title":"Diabetologia"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-0079","article-title":"Neonatal morbidities and developmental delay in moderately preterm-born children","volume":"130","author":"Kerstjens","year":"2012","journal-title":"Pediatrics"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1056\/NEJMoa0707943","article-title":"Hyperglycemia and adverse pregnancy outcomes","volume":"358","author":"Metzger","year":"2008","journal-title":"N Engl J Med"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2010.01140.x","article-title":"Disparities in the risk of gestational diabetes by race-ethnicity and country of birth: Gestational diabetes and race\/ethnicity","volume":"24","author":"Hedderson","year":"2010","journal-title":"Paediatric Perinatal Epidemiol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1001\/jama.2021.7217","article-title":"Trends in gestational diabetes at first live birth by race and ethnicity in the US, 2011 - 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