{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T21:45:41Z","timestamp":1788039941012,"version":"build-2784847793"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>It is unclear if impaired thyroid hormone sensitivity interacts with homocysteine (Hcy), a known risk factor for cardiovascular diseases (CVD), despite the fact that it has been identified as a prevalent metabolic condition.We aimed to analyze the association between thyroid hormone sensitivity indices and homocysteine levels in a Chinese health check-up population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thyroid hormone sensitivity was assessed by the Thyroid Feedback Quantization Index (TFQI), the parameter TFQI (PTFQI), the TSH index (TSHI) and the thyrotropin thyroxine resistance index (TT4RI) and FT3\/FT4 ratio. Linear regression analyses, logistic regression analyses and restricted cubic spline were used to investigate the relationship between thyroid hormone sensitivity and Hcy levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study included 11144 medical examiners. Subjects with impaired thyroid hormone sensitivity had higher Hcy levels, according to the results (P &amp;lt; 0.001). Quartiles of TFQI, PTFQI, TSHI, and TT4RI were linked to Hcy levels, according to logistic regression analysis, and these associations persisted even after controlling for a number of risk factors. The odds ratio (95% CI) for Hyperhomocysteinemia (HHcy) in the highest quartile of TFQI was 1.294(1.114,1.504), for PTFQI was 1.293 (1.113, 1.503), and for TSHI was 1.222 (1.050, 1.422) (P &amp;lt; 0.001) after controlling for age, sex, body mass index, dyslipidemia, diabetes, and hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A significant association between impaired thyroid hormone sensitivity and elevated Hcy levels exists in a Chinese population with normal thyroid function.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1634589","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T04:21:52Z","timestamp":1759378912000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The relationship between thyroid hormones sensitivity and hyperhomocysteinemia: a cross-sectional study based on Chinese health check-up 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