{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:43:47Z","timestamp":1792205027813,"version":"4.4.0"},"reference-count":104,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The circadian system organizes during 24 hours the temporal variations in biological processes such as the cell cycle, metabolism, and hormone production. This occurs by a transcriptional\/translational feedback loop of core clock genes, namely,\n                      <jats:italic>BMAL1<\/jats:italic>\n                      ,\n                      <jats:italic>PER1-3<\/jats:italic>\n                      , and\n                      <jats:italic>CRY1-2<\/jats:italic>\n                      . The CLOCK\u2013BMAL1 complex regulates clock-controlled genes like WEE1 kinase, a key modulator of mitotic entry and placental cell proliferation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to identify temporally regulated gene expression patterns in the human placenta using bioinformatics analysis of available microarrays in Gene Expression Omnibus (GEO) datasets and to validate selected findings in cultured placental explants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Temporal microarray data from the GEO were analyzed to identify circadian and cell cycle-related genes. Selected targets were validated\n                      <jats:italic>in vitro<\/jats:italic>\n                      using explant cultures of human placenta sampled every 4 hours for 36 hours, with or without 10 nM melatonin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We observed rhythmic expression of\n                      <jats:italic>BMAL1<\/jats:italic>\n                      ,\n                      <jats:italic>PER1<\/jats:italic>\n                      ,\n                      <jats:italic>PER2<\/jats:italic>\n                      , and\n                      <jats:italic>WEE1<\/jats:italic>\n                      in human placental explants, consistent with the temporal patterns detected\n                      <jats:italic>in silico<\/jats:italic>\n                      . Melatonin treatment suppressed the circadian oscillation of\n                      <jats:italic>BMAL1<\/jats:italic>\n                      ,\n                      <jats:italic>PER2<\/jats:italic>\n                      , and\n                      <jats:italic>WEE1<\/jats:italic>\n                      . Interestingly, the placenta produced melatonin steadily over 36 hours, and exogenous melatonin did not alter this production.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2025.1640635","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T05:29:29Z","timestamp":1761715769000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Melatonin modulates the gene expression of WEE1 kinase and clock genes: a crosstalk between the molecular clocks of the placenta?"],"prefix":"10.3389","volume":"16","author":[{"given":"Carlos","family":"Venegas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevins","family":"Jara-Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Cueto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Cabello-Guzm\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"Lagunas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Lillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Valenzuela-Melgarejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086271","article-title":"Control mechanism of the circadian clock for timing of cell division in vivo","volume":"302","author":"Matsuo","year":"2003","journal-title":"Sci (New York N.Y.)"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090810","article-title":"Circadian rhythms. 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