{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:06:11Z","timestamp":1788833171331,"version":"build-2803163510"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>About 15% of neonates suffer from hypoglycemia. Hypothermia is associated with hypoglycemia; however, there are limited empiric data analyzing this association. Accordingly, hypothermia is not listed as a risk factor in many hypoglycemia guidelines. This study aimed to analyze hypothermia in regard to neonatal hypoglycemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective study of 1018 neonates \u226535 + 0 weeks. Neonates at-risk for hypoglycemia (n=857) received a standardized blood glucose (BG) screening\/management. Controls (n=161) received at least two BG measurements at 2\u20133 and 36\u201372 hours. Rectal temperature was measured at 1\u20133 hours, upon transfer to the maternity\/pediatric ward, and at clinical discretion (hypothermia = &amp;lt;36.5\u00b0C).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>236\/1018 (23.2%) neonates had at least one episode of hypothermia. More hypothermic compared to non-hypothermic neonates had hypoglycemia \u22642.5 mmol\/l (\u226445 mg\/dl) (53.4% vs. 26.2%, P&amp;lt;.001) and &amp;lt;1.7 mmol\/l (&amp;lt;30 mg\/dl) (12.7% vs. 1.4%, P&amp;lt;.001), and subsequently required treatment more frequently. Small for gestational age (SGA) and\/or fetal growth restriction (FGR), prematurity and perinatal stress were associated with a higher risk for hypothermia. In SGA and\/or FGR neonates the incidence of hypoglycemia \u22642.5 mmol\/l (\u226445 mg\/dl) and &amp;lt;1.7 mmol\/l (&amp;lt;30 mg\/dl) was higher for hypothermic compared to non-hypothermic neonates (58% vs. 35%, P&amp;lt;.001 and 15% vs. 4%, P=.003).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hypothermia was strongly associated with neonatal hypoglycemia, leading to more frequent hypoglycemic episodes and a greater need for treatment. Further prospective studies are needed to elucidate the direction of causality between both conditions and to assess the effectiveness of thermal management strategies in reducing hypoglycemia. Awareness should be raised to rule out hypoglycemia in case of hypothermia, and vice versa.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2025.1641140","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T04:14:08Z","timestamp":1756268048000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of neonatal hypothermia with neonatal 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