{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T10:11:40Z","timestamp":1758190300042,"version":"3.44.0"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pediatric obesity is a growing global health concern, and interventions aimed at increasing resting energy expenditure (REE) have gained attention as complementary strategies to dietary restriction. Whole-body vibration (WBV), an innovative exercise mimetic, may offer metabolic and functional benefits, particularly in populations with limited exercise tolerance. This study was a randomized clinical trial aimed to evaluate the effects of incorporating WBV into a 3-week in-hospital multidisciplinary body weight reduction program (BWRP) in male adolescents with obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty-three male adolescents with obesity (mean age: 15.7 \u00b1 1.3 years; mean body mass index (BMI): 38.5 \u00b1 5.6 kg\/m<jats:sup>2<\/jats:sup>) hospitalized for a 3-week BWRP were randomly assigned to a control group receiving the standard BWRP (subgroup A, n = 12) or an experimental group receiving BWRP plus WBV sessions (subgroup B, n = 11). Anthropometric and clinical parameters, REE, and lower limb muscle power, evaluated using the stair-climbing test, were assessed before and after the intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both subgroups demonstrated significant reductions in body weight and BMI. REE showed a significant Time \u00d7 Group interaction (p &amp;lt; 0.01), indicating differential responses between the two intervention groups. WBV training significantly increased REE in subgroup B, from 2470.1 \u00b1 249.6 kcal\/day at baseline to 2733.0 \u00b1 310.8 kcal\/day post-intervention (\u0394 = +262.9 kcal, p &amp;lt; 0.001). In contrast, subgroup A showed no significant change in REE, with values decreasing from 2204.0 \u00b1 307.4 kcal\/day to 2020.8 \u00b1 442.5 kcal\/day (\u0394 = \u02d7183.2 kcal, p = ns). REE change was supported by significant Time \u00d7 Group interaction in a two-way repeated measures ANOVA (p = 0.002). Furthermore, a significant post-intervention correlation emerged between REE and anaerobic power only in subgroup B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The addition of WBV to a structured BWRP significantly increased REE in obese adolescents, beyond the effects of the BWRP alone. This finding supports the use of WBV as a promising adjunct strategy to conventional interventions in pediatric obesity.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1642437","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T04:19:09Z","timestamp":1758082749000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Whole-body vibration administered during a 3-week in-hospital multidisciplinary body weight reduction program increases resting energy expenditure in obese adolescents, a randomized clinical trial"],"prefix":"10.3389","volume":"16","author":[{"given":"Sofia","family":"Tamini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Tringali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"De 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