{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T20:12:47Z","timestamp":1769285567047,"version":"3.49.0"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Parathyroid carcinoma (PC), an extremely rare endocrine malignancy, disrupts calciumphosphorus homeostasis and lead to musculoskeletal system disorders including osteoporosis, bone pain and pathological fractures. For postmenopausal women, osteoporosis is a common disease. Therefore, secondary osteoporosis is often overlooked in this demographic. We report a 54-year-old woman presenting to Orthopedics Department due to arthralgia diagnosed with severe postmenopausal osteoporosis (PMO). After pharmacotherapy, the patient\u2019s symptoms did not show significant improvement. Subsequent endocrine evaluation revealed hyperparathyroidism as the underlying cause. Following parathyroidectomy, histopathological evaluation confirmed the diagnosis of PC and her osteoporosis symptoms improved. This case highlights the critical need for postmenopausal women with osteoporosis to determine whether their condition is primary or secondary in nature. Moreover, the therapeutic principles for managing primary and secondary osteoporosis differ substantially. Early etiological identification is essential to optimize management.<\/jats:p>","DOI":"10.3389\/fendo.2025.1652919","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:55:56Z","timestamp":1769165756000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Parathyroid carcinoma as an overlooked etiology of osteoporosis in postmenopausal women: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Jing","family":"Su","sequence":"first","affiliation":[{"name":"Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqiong","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiyuan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongzhi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenshan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.081018","article-title":"Parathyroid carcinoma","volume":"23","author":"Marcocci","year":"2008","journal-title":"J Bone Miner Res"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22599","article-title":"Trends in the incidence and treatment of parathyroid cancer in the United States","volume":"109","author":"Lee","year":"2007","journal-title":"Cancer"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2024.101966","article-title":"Parathyroid carcinoma: New insights","volume":"101966","author":"Viswanath","year":"2024","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e220287","DOI":"10.1530\/ERC-22-0287","article-title":"Diagnosis and management of parathyroid carcinoma: a state-of-the-art review","volume":"30","author":"Roser","year":"2023","journal-title":"Endocr-Relat Cancer"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2018.11.002","article-title":"Parathyroid carcinoma","volume":"32","author":"Salcuni","year":"2018","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-023-03376-w","article-title":"Parathyroid carcinoma: molecular therapeutic targets","volume":"81","author":"Marini","year":"2023","journal-title":"Endocrine"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12458","article-title":"Molecular genetics and epigenetics of nonfamilial (sporadic) parathyroid tumours","volume":"280","author":"Westin","year":"2016","journal-title":"J Intern Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.clon.2010.04.007","article-title":"Parathyroid carcinoma","volume":"22","author":"Givi","year":"2010","journal-title":"Clin Oncol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.5339\/jlghs.2016.2","article-title":"Osteoporosis: An under-recognized public health problem: Local and global risk factors and its regional and worldwide prevalence","volume":"2016","author":"Vijayakumar","year":"2016","journal-title":"J Loc Global Health Sci"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp2307353","article-title":"Postmenopausal osteoporosis","volume":"389","author":"Walker","year":"2023","journal-title":"N Engl J Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s00198-008-0560-z","article-title":"on behalf of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). European guidance for the diagnosis and management of osteoporosis in postmenopausal women","volume":"19","author":"Kanis","year":"2008","journal-title":"Osteoporos Int"},{"key":"B12","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/s41413-023-00280-x","article-title":"Low back pain and osteoarthritis pain: a perspective of estrogen","volume":"11","author":"Pang","year":"2023","journal-title":"Bone Res"},{"key":"B13","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12880-021-00616-1","article-title":"Efficacy of ultrasonography and Tc-99m MIBI SPECT\/CT in preoperative localization of parathyroid adenomas causing primary hyperthyroidism","volume":"21","author":"Lu","year":"2021","journal-title":"BMC Med Imaging"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.3432","article-title":"Diagnosis and management of parathyroid carcinoma","volume":"116","author":"Lazzaro","year":"2024","journal-title":"Clin Pharma Ther"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2012.27.8.890","article-title":"Preoperative predictive factors for parathyroid carcinoma in patients with primary hyperparathyroidism","volume":"27","author":"Bae","year":"2012","journal-title":"J Kor Med Sci"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13010147","article-title":"The nexus of hyperparathyroidism and thyroid carcinoma: insights into pathogenesis and diagnostic challenges\u2014A narrative review","volume":"13","author":"Scerrino","year":"2023","journal-title":"JCM"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1530\/EC-21-0217","article-title":"Increased thyroid Malignancy in patients with primary hyperparathyroidism","volume":"10","author":"Li","year":"2021","journal-title":"Endocr Connect"},{"key":"B18","doi-asserted-by":"publisher","first-page":"69","DOI":"10.12701\/yujm.2017.34.1.69","article-title":"Follow-up of thyroid ultrasonography in patients with hemodialysis","volume":"34","author":"Kim","year":"2017","journal-title":"Yeungnam Univ J Med"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.4158\/EP-2018-0016","article-title":"Unknown and already known thyroid abnormalities in primary hyperparathyroidism","volume":"24","author":"Latina","year":"2018","journal-title":"Endocr Pract"},{"key":"B20","article-title":"[J]. Chinese General Pract.","year":"2022"},{"key":"B21","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s11657-025-01588-3","article-title":"The 2024 UK clinical guideline for the prevention and treatment of osteoporosis","volume":"20","author":"Gregson","year":"2025","journal-title":"Arch Osteoporos"},{"key":"B22","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1097\/AOG.0000000000004514","article-title":"Osteoporosis prevention, screening, and diagnosis: ACOG clinical practice guideline no. 1","volume":"138","year":"2021","journal-title":"Obstet Gynecol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4158\/GL-2020-0524SUPPL","article-title":"American association of clinical endocrinologists\/american college of endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis\u20142020 update","volume":"26","author":"Camacho","year":"2020","journal-title":"Endocr Pract"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-021-05900-y","article-title":"The clinician\u2019s guide to prevention and treatment of osteoporosis","volume":"33","author":"LeBoff","year":"2022","journal-title":"Osteoporos Int"},{"key":"B25","article-title":"Society of Parathyroid and Metabolic Bone Diseases, Rare Diseases Society, Chinese Research Hospital Association. Expert consensus on the management of parathyroid carcinoma","volume-title":"Chin J. Endocrinol. Metabol.","year":"2019"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac621","article-title":"Treatment of hypercalcemia of Malignancy in adults: an endocrine society clinical practice guideline","volume":"108","author":"El-Hajj Fuleihan","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2024.103664","article-title":"Neuroendocrine neoplasms of head and neck, genitourinary and gynaecological systems, unknown primaries, parathyroid carcinomas and intrathyroid thymic neoplasms: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"9","author":"Hadoux","year":"2024","journal-title":"ESMO Open"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1652919\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:55:57Z","timestamp":1769165757000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1652919\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,23]]},"references-count":27,"alternative-id":["10.3389\/fendo.2025.1652919"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2025.1652919","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,23]]},"article-number":"1652919"}}