{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:06:16Z","timestamp":1791576376191,"version":"4.3.4"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Accurate preoperative localization of parathyroid adenomas is of great importance to ensure targeted and effective surgical treatment of primary hyperparathyroidism (PHPT). In this context, parathyroid fine-needle aspiration biopsy (FNAB) performed under ultrasound guidance plays a crucial role. This study aimed to evaluate the relationship between ultrasonographic features of parathyroid adenomas and parathyroid hormone washout (PTH-WO) values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between January 2022 and August 2024, data from 128 parathyroid adenomas in 122 patients who were prepared for surgery due to PHPT and underwent ultrasound-guided FNAB along with PTH-WO testing were retrospectively evaluated. The obtained PTH-WO results were compared with B-mode and Doppler ultrasound findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In adenomas with a long axis greater than 10 mm and those containing cystic components, PTH-WO levels were found to be significantly higher (p = 0.005 and p = 0.02, respectively). Additionally, a positive correlation was identified between PTH-WO levels and the short and long axis dimensions of the adenomas. In contrast, no significant relationship was observed between PTH-WO levels and B-mode (grayscale) or Doppler (vascularity) ultrasound features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PTH-WO values vary according to the ultrasonographic dimensions of parathyroid adenomas and are measured at higher levels in cystic adenomas. Other ultrasonographic features do not significantly affect PTH-WO levels. Therefore, the size of the lesion should be taken into account when interpreting PTH-WO results.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1654110","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:12:01Z","timestamp":1757995921000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Lesion size and cystic morphology are key determinants of parathyroid hormone washout in primary hyperparathyroidism"],"prefix":"10.3389","volume":"16","author":[{"given":"\u0130lker","family":"\u00c7ordan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oguzhan","family":"Aksu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4677","article-title":"Evaluation 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