{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T04:42:25Z","timestamp":1759898545582,"version":"build-2065373602"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effect of short-term intensive insulin (STII) pump therapy on serum endotrophin (ETP) levels in patients with newly diagnosed type 2 diabetes, examine the relationship between serum ETP levels and insulin resistance (IR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and methods<\/jats:title><jats:p>Our study recruited 40 patients with newly diagnosed type 2 diabetes and 40 healthy controls. First, we compared the serum ETP levels between patients with newly diagnosed type 2 diabetes and controls. Second, 40 patients with newly diagnosed type 2 diabetes underwent two weeks of STII pump therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher serum ETP levels were observed in patients with newly diagnosed type 2 diabetes compared to controls. After 2 weeks of STII pump therapy, serum ETP levels significantly attenuated in patients with newly diagnosed type 2 diabetes. Both before and after treatment, serum ETP exhibited a significant positive correlation with homeostasis model 2 assessment of IR (HOMA2-IR). Multiple linear regression analysis revealed that changes in ETP levels (\u03b4-ETP) were independently associated with changes in HOMA2-IR (\u03b4-HOMA2-IR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum ETP serves as a risk factor for type 2 diabetes and correlates with insulin resistance index. STII contributed to reducing the heightened inflammatory response in individuals with type 2 diabetes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1658272","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T04:18:38Z","timestamp":1759897118000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of short-term intensive insulin pump therapy on serum endotrophin levels in patients with newly diagnosed type 2 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