{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:38:15Z","timestamp":1785458295336,"version":"3.56.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the correlation between 1-hour postprandial glucose (1h-PG) and the triglyceride-glucose (TyG) index in type 2 diabetes mellitus (T2DM) subjects and to evaluate the predictive utility of 1h-PG for insulin resistance (IR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Research design and methods<\/jats:title>\n                    <jats:p>Based on the criteria of 1h-PG \u2265 8.6mmol\/L and 2h-PG \u2265 11.1mmol\/L from the 125-gram standard steamed buns meal test, 1835 T2DM individuals were categorized as follows: Group 1: 1h-PG &amp;lt; 8.6mmol\/L; Group 2: 1h-PG \u2265 8.6mmol\/L and 2h-PG &amp;lt; 11.1mmol\/L; Group 3: 1h-PG \u2265 8.6mmol\/L and 2h-PG \u2265 11.1mmol\/L. The severity of IR was assessed using the TyG index, with thresholds of &amp;gt; 8.81 for males and &amp;gt; 8.73 for females. Clinical and laboratory parameters, including glucose, C-peptide, insulin and lipid profiles were analyzed. Statistical analyses included Spearman\u2019s correlation, logistic regression, and receiver operating characteristic (ROC) curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      1h-PG exhibited a more pronounced positive correlation with the TyG index (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.273) than 2h-PG (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.173). A statistically significant increase in the TyG index was observed in Group 2 compared with Group 1. Although Group 3 showed a trend toward a higher TyG index compared to Group 2, the difference was not statistically significant. The higher insulin resistance group exhibited significantly higher 1h-PG levels compared to the lower insulin resistance group. Logistic regression confirmed that the association between 1h-PG and the TyG index was stronger (\n                      <jats:italic>OR<\/jats:italic>\n                      = 1.170, 95%\n                      <jats:italic>CI<\/jats:italic>\n                      : 1.133\u20131.209,\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001) than that of 2h-PG (\n                      <jats:italic>OR<\/jats:italic>\n                      = 1.091, 95%\n                      <jats:italic>CI<\/jats:italic>\n                      : 1.062\u20131.121,\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001). ROC analysis revealed that 1h-PG achieved a higher AUC for predicting IR than 2h-PG (0.629\n                      <jats:italic>vs<\/jats:italic>\n                      . 0.589,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt; 0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among T2DM subjects, 1h-PG shows a stronger association with the TyG index than 2h-PG. These findings support the potential of 1h-PG as a more sensitive and cost-effective marker for early identification of insulin resistance, offering clinical utility in diabetes diagnosis and management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2025.1671040","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T05:14:49Z","timestamp":1767935689000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["1-hour post-load plasma glucose: a reliable marker of insulin resistance in type 2 diabetes, as determined by the TyG 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