{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:36:38Z","timestamp":1791434198332,"version":"4.3.3"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary hyperparathyroidism (PHPT) is associated with an increased risk of kidney stones. However, the clinical utility of 24-hour urinary calcium (24h-UCa) as a predictor of nephrolithiasis, and its role in surgical decision-making, remains uncertain due to inconsistent findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate whether 24h-UCa is a reliable disease-specific predictor of kidney stone risk in patients with PHPT and to identify demographic and biochemical determinants of urinary calcium excretion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 306 PHPT patients who underwent curative parathyroidectomy for confirmed adenoma. Demographics, kidney stone history, and biochemical data were collected. T-tests, chi-square tests, multivariate logistic regression, and multiple regression were used to analyze associations of 24h-UCa with kidney stones, demographic, and biochemical indices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Kidney stones were present in 22% of patients. No significant difference in 24h-UCa was observed between stone-formers and non-stone-formers, even after adjustment for age, gender, and race. In contrast, 24h-UCa was significantly higher in men and white patients, with hypercalciuria more prevalent among white individuals. Serum calcium and eGFR were also significantly positively associated with 24h-UCa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest that 24h-UCa is not an independent predictor of kidney stone risk in PHPT and is largely influenced by demographic and biochemical factors. Accordingly, routine 24h-UCa measurement for evaluating patients with sporadic PHPT or for guiding parathyroidectomy decisions is not recommended. This study is limited by its retrospective design, reliance on a single urine collection, and lack of detailed dietary or genetic data, which may have introduced variability and reduced power to detect weak associations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2025.1671905","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T05:11:50Z","timestamp":1764047510000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The predictive value of 24-hour urinary calcium for kidney stone risk in primary hyperparathyroidism: insight from a retrospective study of parathyroid adenoma cases"],"prefix":"10.3389","volume":"16","author":[{"given":"Arti","family":"Bhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aseel","family":"Yaseen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijing","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhaker D.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00198-016-3716-2","article-title":"Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. 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