{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:56:56Z","timestamp":1787162216265,"version":"build-2736575974"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Retinal vein occlusion (RVO) predominantly occurs in individuals over the age of 50, and obesity is a recognized risk factor for its development. The pro-inflammatory metabolic activity of visceral adipose tissue (VAT), which elevates systemic inflammation, is regarded as a key underlying mechanism contributing to the detrimental effects of obesity on atherosclerosis and hypercoagulability in RVO. In this study, we aimed to evaluate the inflammatory metabolic activity of VAT using\n                      <jats:sup>18<\/jats:sup>\n                      F-fluorodeoxyglucose (FDG) positron emission tomography\/computed tomography (PET\/CT) and to examine its association with RVO.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      A total of 22 elderly patients with RVO (aged \u2265 50 years) who underwent\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG PET\/CT for routine health screening, along with 15 age-matched control participants who also underwent\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG PET\/CT for routine health screening, were enrolled. The metabolic activity of VAT was assessed using its maximum standardized uptake value (SUVmax), while systemic inflammation was evaluated based on the SUVmax of the spleen and bone marrow (BM), as well as C-reactive protein (CRP) levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The VAT SUVmax was higher in patients with RVO compared to the non-RVO group. Additionally, levels of systemic inflammation surrogate markers were elevated in patients with RVO relative to those without RVO. Furthermore, VAT SUVmax showed a positive correlation with systemic inflammation surrogate markers and was independently associated with the presence of RVO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The metabolic activity of VAT, as assessed by\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG PET\/CT, was found to be associated with the presence of RVO and correlated with the degree of systemic inflammation. Therefore, VAT SUVmax may serve as a potential surrogate marker for obesity-related VAT inflammation linked to RVO.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2025.1679216","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T04:21:23Z","timestamp":1759378883000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between metabolic activity of visceral adipose tissue and retinal vein occlusion: a preliminary 18F-FDG PET\/CT 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