{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T02:04:27Z","timestamp":1769825067267,"version":"3.49.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017712","name":"Bureau of Science and Technology of Ganzhou Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017712","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the associations of serum chemokine C\u2013C motif 21 (CCL21) and chemokine C\u2013C motif receptor 7 (CCR7) levels with the Hashimoto\u2019s thyroiditis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited 244 subjects (183 with Hashimoto\u2019s thyroiditis and 61 healthy controls) from the Second People\u2019s Hospital of Huai\u2019an City. Patients with Hashimoto\u2019s thyroiditis were divided into three groups according to the type of thyroid autoantibody: a. Double-positive group [elevated both thyroglobulin antibody (TgAb) and thyroid peroxidase antibody (TPOAb)]; b. TgAb group (elevated TgAb only); c. TPOAb group (elevated TPOAb only), they were further stratified according to thyroid function. We analyzed the between-group differences in the serum CCL21 and CCR7 levels which were quantified by enzyme-linked immunosorbent assay in all subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with the healthy control group, the Hashimoto\u2019s thyroiditis group had significantly increased serum CCL21 [154.92 (147.01, 165.34) vs 123.74 (118.02,129.22), p&amp;lt;0.001] and CCR7 [19.15 (18.19, 19.71) vs 16.47 (15.88, 17.14), p&amp;lt;0.001], decreased free triiodothyronine, and increased thyroid stimulating hormone, TgAb, and TPOAb. Correlation analysis revealed that serum CCL21 levels were positively correlated with TgAb and TPOAb levels. Univariate binary logistic regression analysis showed that elevated serum CCL21 [OR = 2.944, 95% CI (1.464, 5.919), p=0.002] was significantly associated with Hashimoto\u2019s thyroiditis. The results of receiver operating characteristic curve analysis indicated that CCL21 has value for the diagnosis of Hashimoto\u2019s thyroiditis [AUC (95% CI)=0.998 (0.996-1.000), p&amp;lt;0.001]. Subgroup analysis suggested that serum CCL21 levels were significantly higher in the double-positive group than in the TgAb and TPOAb groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum CCL21 is significantly elevated in patients with Hashimoto\u2019s thyroiditis and correlates with both TgAb and TPOAb levels, suggesting that it is closely related to Hashimoto\u2019s thyroiditis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2025.1682553","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T05:31:10Z","timestamp":1761715870000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of serum chemokine (C\u2013C motif) 21 and receptor (C\u2013C motif) 7 with Hashimoto\u2019s thyroiditis\u2014\u2014a preliminary clinical 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