{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:59:14Z","timestamp":1791950354129,"version":"4.3.4"},"reference-count":157,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NO.82174163"],"award-info":[{"award-number":["NO.82174163"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["No. ZR2020MH387"],"award-info":[{"award-number":["No. ZR2020MH387"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>\n                    Endocrine disorders are prevalent worldwide, with particularly high incidence rates of thyroid diseases and diabetes mellitus (DM), which impose a substantial burden on healthcare systems. Life-long medication is often required to manage these conditions.\n                    <jats:italic>Scrophulariae Radix<\/jats:italic>\n                    is a traditional Chinese medicine. It contains various chemical components, such as iridoids, phenylpropanoids, and organic acids. These components show anti-inflammatory, antioxidative, and immunomodulatory effects. They have potential to treat endocrine disorders. They are especially effective for thyroid diseases and DM. This review aims to summarize the mechanisms and effects through which\n                    <jats:italic>Scrophulariae Radix<\/jats:italic>\n                    affects thyroid diseases and DM, providing further guidance for clinical treatment.\n                  <\/jats:p>","DOI":"10.3389\/fendo.2025.1684744","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T05:14:39Z","timestamp":1763702079000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["The mechanism and application of Scrophulariae Radix in the treatment of endocrine disorders: focusing on thyroid diseases and diabetes mellitus"],"prefix":"10.3389","volume":"16","author":[{"given":"Jiaying","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huishan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huayuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehan","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0229","article-title":"2016 american thyroid association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis","volume":"26","author":"Ross","year":"2016","journal-title":"Thyroid"},{"key":"B2","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ejim.2023.06.005","article-title":"Management of thyroid dysfunction and thyroid nodules in the ageing patient","volume":"116","author":"Mart\u00ednez-Montoro","year":"2023","journal-title":"Eur J Intern Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.5603\/NMR.2011.0006","article-title":"Primary hyperthyroidism\u2013diagnosis and treatment. 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