{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:38:14Z","timestamp":1789475894930,"version":"build-2803163510"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aims to evaluate the impact of endometriotic cysts and prior ovarian endometriotic cystectomy on ovarian reserve function in women with endometriosis undergoing assisted reproductive technology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this retrospective cohort study, 3,517 endometriosis patients receiving\n                      <jats:italic>in vitro<\/jats:italic>\n                      fertilization\/intracytoplasmic sperm injection (IVF\/ICSI) between January 2016 and April 2022 were reviewed. Participants were stratified into three groups: Group A (control, n=494): patients without endometriosis undergoing IVF\/ICSI for male factor infertility; Group B (non-surgical, n=217): endometriosis patients with untreated endometriotic cysts; Group C (surgical, n=122): endometriosis patients with prior cystectomy. Antral follicle count (AFC), follicle-stimulating hormone (FSH), anti-M\u00fcllerian hormone (AMH), gonadotropin (Gn) dose, number of retrieved oocytes, number of mature metaphase II (MII) oocytes and the proportion of patients with diminished ovarian reserve (DOR; AMH&amp;lt;1.1ng\/ml) were compared across groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ovarian reserve markers were highest in Group A [AMH: 2.88 (1.64\u20134.45) ng\/mL; AFC: 13 (8.5\u201317)], followed by Group B [AMH: 2.70 (1.59\u20134.05) ng\/mL; AFC: 11 (7\u201316)], with both significantly exceeding Group C [AMH: 1.97 (1.02\u20133.05) ng\/mL; AFC: 10 (4\u201315)] (all P &amp;lt; 0.01). The incidence of DOR was significantly higher in Group C (26.23%) than in Group A (13.56%) and Group B (12.90%) (P &amp;lt; 0.05). The total Gn dose was significantly higher in Groups B and C than in Group A. The number of retrieved oocytes and MII oocytes did not differ significantly between Groups A and B, but both were significantly higher than in Group C (P &amp;lt; 0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A history of endometriotic cystectomy is associated with significantly diminished ovarian reserve and poorer ovarian response during controlled ovarian stimulation. These findings highlight the importance of individualized surgical decision-making for reproductive-aged women with endometriomas, weighing potential benefits against the risk of iatrogenic damage to ovarian function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2025.1687765","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T05:28:01Z","timestamp":1768800481000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of endometriotic cystectomy on ovarian reserve function and ovulation induction outcomes in women with endometriosis undergoing assisted reproductive technology"],"prefix":"10.3389","volume":"16","author":[{"given":"Yutao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Assisted Reproduction Center, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Outpatient, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Assisted Reproduction Center, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Assisted Reproduction Center, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1000274","article-title":"Clinical practice. 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