{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:56:56Z","timestamp":1790611016762,"version":"4.1.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Acute pancreatitis (AP) is an inflammatory disease of the exocrine pancreas characterized by tissue damage and sometimes necrosis. However, whether severe AP is associated with an increased risk of incident diabetes remains unclear based on real-world data. This study aims to examine the relationship between severe AP and new-onset diabetes after hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study using the Merative\u2122 MarketScan\u00ae claims database (2016\u20132023), identifying patients with AP and no prior history of diabetes at baseline. The exposure, severe AP, was defined by any of the following during hospitalization: pancreatic necrosis, hemodialysis, organ failure, or mechanical ventilation. We used multivariable stratified Cox proportional hazards regression models with propensity score strata to assess the association between severe AP and incident diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The matched study population consisted of 2,046 patients with severe AP and 2,046 patients with mild AP, with baseline characteristics well balanced between groups. Individuals with severe AP had a higher risk of developing diabetes compared with those with mild AP [adjusted hazard ratio (aHR) = 1.64, 95% confidence interval (CI): 1.30\u20132.06], after accounting for propensity score matching. The association between severe AP and incident diabetes was stronger in men (aHR = 2.03, 95% CI: 1.50\u20132.74) than in women (aHR = 1.06, 95% CI: 0.69\u20131.64;\n                      <jats:italic>P<\/jats:italic>\n                      -\n                      <jats:sub>interaction<\/jats:sub>\n                      = 0.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>In this large real-world data study, severe AP was associated with an increased risk of developing diabetes. These findings underscore the importance for glycemic surveillance and the need to consider proactive management of severe AP patients to mitigate their risk of poor health outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2025.1704688","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T05:10:41Z","timestamp":1763097041000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between severe acute pancreatitis and new-onset diabetes: a propensity score-matched real-world study"],"prefix":"10.3389","volume":"16","author":[{"given":"Djibril M.","family":"Ba","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences, Penn State College of Medicine","place":["Hershey, PA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil A.","family":"Hart","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, College of Medicine, The Ohio State University Wexner Medical Center","place":["Columbus, OH, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Penn State College of Medicine","place":["Hershey, PA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somashekar G.","family":"Krishna","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, College of Medicine, The Ohio State University Wexner Medical Center","place":["Columbus, OH, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Fudan University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas L.","family":"Leslie","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Penn State College of Medicine","place":["Hershey, PA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bradley","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Penn State College of Medicine, United States","place":["Hershey, PA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Maranki","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Penn State College of Medicine, United States","place":["Hershey, PA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadiyatu","family":"Fofana","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Penn State College of Medicine, United States","place":["Hershey, PA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vernon M.","family":"Chinchilli","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Penn State College of Medicine","place":["Hershey, PA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana R.","family":"Pichardo-Lowden","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Penn State College of Medicine","place":["Hershey, PA, United States"]},{"name":"Department of Medicine, Division of Endocrinology, Penn State College of Medicine, United States","place":["Hershey, PA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.11.082","article-title":"Acute 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