{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:31:55Z","timestamp":1770820315604,"version":"3.50.1"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The triglyceride-glucose (TyG) index is a novel marker of insulin resistance associated with carotid vascular disease; however, its role in type 2 diabetes mellitus (T2DM) remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study enrolled patients with T2DM who underwent repeated hospitalizations at our hospital between 2014 and 2024. Participants were stratified into tertiles based on TyG index values. Multivariable regression analyses were performed to assess the association between TyG index levels and carotid plaque progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 548 patients with T2DM (55.93 \u00b1 12.26 years, 60.4% males) were included, with a median follow-up time of 4 (2\u20137) years. The prevalence of carotid plaque progression increased stepwise with higher TyG tertiles (45.9% vs. 62.6% vs. 57.4%; p = 0.004), and the growth rates of bilateral plaque length and width also increased (all p &amp;lt; 0.05). The positive association between the TyG index and the growth rates of left carotid plaque length, left width, and right width remained significant in the fully adjusted model (TyG, per 1-unit increase: 0.197\u00a0mm vs. 0.196\u00a0mm vs. 0.189\u00a0mm; tertiles of TyG: 0.156\u00a0mm vs. 0.162\u00a0mm vs. 0.164\u00a0mm; all p &amp;lt; 0.05). After multivariable adjustment, Cox regression analysis showed that higher TyG index levels were associated with 1.261-fold, 1.244-fold, and 1.378-fold increased risks of carotid plaque progression in patients with T2DM (all p &amp;lt; 0.05). ROC curve analysis indicated that the TyG index exhibited modest predictive value for carotid plaque progression in patients with T2DM, with an AUC of 0.556 (p = 0.024). Adding the TyG index to the predictive model improved the C-statistic (0.624 vs. 0.649; p &amp;lt; 0.001), NRI = 0.211 (p = 0.015), and IDI = 0.020 (p &amp;lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with T2DM, a higher TyG index is an independent risk factor for carotid plaque progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2025.1709079","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T05:11:48Z","timestamp":1764047508000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between the triglyceride-glucose index and carotid plaque progression in patients with type 2 diabetes mellitus: a retrospective cohort study"],"prefix":"10.3389","volume":"16","author":[{"given":"Zhangxiang","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guojuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qibao","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adr4731","article-title":"Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes","volume":"387","author":"Cho","year":"2025","journal-title":"Science"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/metabo15050342","article-title":"Lipid subclasses differentiate insulin resistance by triglyceride-glucose index","volume":"15","author":"Naja","year":"2025","journal-title":"Metabolites"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.939482","article-title":"The triglyceride glucose (TyG) index as a sensible marker for identifying insulin resistance and predicting diabetic kidney disease","volume":"29","author":"Li","year":"2023","journal-title":"Med Sci Monit"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2024.04.130","article-title":"The triglyceride-glucose index is superior to homeostasis model assessment of insulin resistance in predicting metabolic syndrome in an adult population in the United States","volume":"18","author":"Adams-Huet","year":"2024","journal-title":"J Clin Lipidol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0288","article-title":"The product of triglycerides and glucose, a simple measure of insulin sensitivity. 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