{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T05:11:18Z","timestamp":1767071478373,"version":"3.48.0"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of thermal ablation (TA) for ATA intermediate-risk papillary thyroid carcinoma (PTC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and materials<\/jats:title>\n                    <jats:p>This retrospective study analyzed ATA intermediate-risk PTC (either ultrasound extrathyroidal extension or cervical lymph node &amp;lt; 3cm metastasis) patients treated with TA at China-Japan Friendship Hospital between April 2018 and December 2023. Outcomes included technical success, recurrence-free survival (RFS), and complications. Multi-Cox regression identified prognostic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 113 people were included. TA demonstrated 100% technical success and complete ablation rates. 18 patients (15.9%) had developed tumor recurrence. The 1-, 3-, and 5-year RFS rates were 95.6%, 83.7%, and 79.8%, respectively. Metastatic lymph node diameter independently predicted progression (HR:3.20,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;0.05). Complications occurred in 21.2% of cases, with 1.8% permanent vocal cord paralysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TA shows promising efficacy and safety for selected ATA intermediate-risk PTC patients, with lymph node size as a key prognostic factor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2025.1736498","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T05:10:21Z","timestamp":1767071421000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Thermal ablation for ata intermediate-risk papillary thyroid carcinoma: efficacy and safety outcomes in a retrospective cohort"],"prefix":"10.3389","volume":"16","author":[{"given":"Tian-hao","family":"Cong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-long","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-liang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-yi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-xiao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-li","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-an","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s12022-022-09707-3","article-title":"Overview of the 2022 WHO classification of thyroid neoplasms","volume":"33","author":"Baloch","year":"2022","journal-title":"Endocr Pathol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.356","article-title":"Active surveillance for patients with very low-risk thyroid cancer","volume":"5","author":"Lohia","year":"2020","journal-title":"Laryngoscope Investig Otolaryngol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0021","article-title":"Thyroid cancer incidence patterns in the United States by histologic type, 1992-2006","volume":"21","author":"Aschebrook-Kilfoy","year":"2011","journal-title":"Thyroid"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.07.023","article-title":"Extrathyroidal extension is not all equal: Implications of macroscopic versus microscopic extent in papillary thyroid carcinoma","volume":"144","author":"Arora","year":"2008","journal-title":"Surgery"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-021-08478-5","article-title":"Risk factors for metastasis in indeterminate lymph nodes in preoperative patients with thyroid cancer","volume":"32","author":"Chung","year":"2022","journal-title":"Eur Radiol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(20)30372-7","article-title":"Thyroid cancer in the USA: current trends and outstanding questions","volume":"9","author":"Davies","year":"2021","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.698689","article-title":"Update of radiofrequency ablation for treating benign and Malignant thyroid nodules. 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