{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T08:28:54Z","timestamp":1771921734299,"version":"3.50.1"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>\n                    Carbohydrate-responsive element binding protein (ChREBP) and Max-like protein X (MLX) are key Mondo Family Proteins (MFPs) acting as transcription factors. They are known to couple intracellular sugar levels with carbohydrate and lipid metabolism by regulating glucose-responsive gene expression. MondoA regulates lipid metabolism and insulin signaling in addition to controlling glucose uptake, whereas ChREBP primarily regulates\n                    <jats:italic>de novo<\/jats:italic>\n                    lipogenesis and glycolysis. Differential gene expression data suggest that the expression of MondoA and ChREBP is cell type-specific, which is an important consideration when designing therapeutic strategies to control MFP-regulated transcriptional programs for different tissue-specific systems. In this review, we summarize recent advances made in the research field studying diabetes and its multi-organ complications, including those affecting the kidney, liver, heart, and retina. We also discuss recent advances in MFP-targeted therapies.\n                  <\/jats:p>","DOI":"10.3389\/fendo.2025.1745162","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:14:18Z","timestamp":1768454058000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mondo family proteins in diabetes"],"prefix":"10.3389","volume":"16","author":[{"given":"Sandeep Kumar","family":"Barodia","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Wake Forest University Medical School","place":["Winston-Salem, NC, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria B.","family":"Grant","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Alabama at Birmingham","place":["Birmingham, AL, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina 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