{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:07:14Z","timestamp":1790723234473,"version":"4.1.0"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Inflammation and metabolic disorders play important roles in the pathogenesis of acute coronary syndrome(ACS). The C-reactive protein-triglyceride-glucose index(CTI) is a novel combined inflammatory-metabolic indicator. This study aimed to evaluate the association between CTI and in-hospital major adverse cardiovascular events(MACE) in ACS patients after percutaneous coronary intervention(PCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective observational study consecutively enrolled 300 patients who underwent PCI for ACS at our hospital from January 2023 to October 2025. C-reactive protein(CRP),triglyceride(TG), and fasting plasma glucose (FPG) were measured upon admission, and CTI values were calculated. Patients were divided into Q1-Q4 groups according to CTI quartiles. The primary endpoint was in-hospital MACE, defined as a composite of cardiac death, acute stent thrombosis, recurrent myocardial infarction, acute heart failure, and cardiogenic shock. Multivariate logistic regression analysis was used to assess the association between CTI and in-hospital MACE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 300 patients, 73 (24. 3%) experienced in-hospital MACE. Compared with the Q1 group, patients in the Q4 group had significantly higher incidence of MACE (10. 7%\n                      <jats:italic>vs<\/jats:italic>\n                      44. 0%, P&amp;lt;0. 001). Multivariate analysis showed that, after adjusting for traditional risk factors, the highest CTI quartile group(Q4) remained significantly associated with MACE risk (adjusted OR 3. 28, 95%CI 1. 42-7. 56, P , 0. 005). For each standard deviation increase in CTI, the risk of MACE increased by 46% (OR 1. 46, 95%CI 1. 21-1. 76, P&amp;lt;0. 001). CTI demonstrated better predictive value for MACE (AUC, 0. 703, 95%CI 0. 641-0. 766) compared to CRP (AUC, 0. 610), TG (AUC, 0. 655), or FPG (AUC, 0. 678) alone (all P&amp;lt;0. 05). Subgroup analysis showed that CTI had stronger predictive ability in patients with ST-segment elevation myocardial infarction, diabetes, and multivessel disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated CTI levels after PCI in ACS patients are significantly associated with increased risk of in-hospital MACE. CTI may be an effective tool for evaluating short-term prognosis in ACS patients after PCI, providing reference for early risk stratification and enhanced monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2025.1745588","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:34:15Z","timestamp":1768286055000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between elevated C-reactive protein-triglyceride-glucose index and in-hospital major adverse cardiovascular events in acute coronary syndrome patients after percutaneous coronary intervention: a single-center prospective observational study"],"prefix":"10.3389","volume":"16","author":[{"given":"Hai","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa575","article-title":"2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation","volume":"42","author":"Collet","year":"2021","journal-title":"Eur Heart J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global burden of cardiovascular diseases and risk factors, 1990-2019, update from the GBD 2019 study","volume":"76","author":"Roth","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0119-4","article-title":"Epidemiology of cardiovascular disease in China, current features and implications","volume":"16","author":"Zhao","year":"2019","journal-title":"Nat Rev Cardiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1016\/j.rec.2017.11.010","article-title":"2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation","volume":"70","author":"Ib\u00e1nez","year":"2017","journal-title":"Rev espanola cardiologia (English ed)"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx515","article-title":"Improved outcomes in patients with ST-elevation myocardial infarction during the last 20\u2009years are related to implementation of evidence-based treatments, experiences from the SWEDEHEART registry 1995-2014","volume":"38","author":"Szummer","year":"2017","journal-title":"Eur Heart J"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.09.009","article-title":"Inflammation in atherosclerosis, from pathophysiology to practice","volume":"54","author":"Libby","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318921","article-title":"C-reactive protein, a critical update","volume":"111","author":"Pepys","year":"2003","journal-title":"J Clin Invest"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2007.087957","article-title":"Clinical application of C-reactive protein across the spectrum of acute coronary syndromes","volume":"53","author":"Scirica","year":"2007","journal-title":"Clin Chem"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408183310701","article-title":"The prognostic value of C-reactive protein and serum amyloid a protein in severe unsta ble angina","volume":"331","author":"Liuzzo","year":"1994","journal-title":"New Engl J Med"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200010193431602","article-title":"Markers of myocardial damage and inflammation in relation to long-term mortality in unsta ble coronary artery disease. 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