{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:30:40Z","timestamp":1768206640573,"version":"3.49.0"},"reference-count":12,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>A 52-year-old Caucasian male sought treatment for age-related testosterone decline. Past medical history included diagnosed hypertension and type 2 diabetes mellitus, with suboptimal glycemic control and no current antidiabetic therapy. He qualified for testosterone replacement therapy and agreed to address his metabolic dysfunction through enhanced lifestyle interventions and a targeted 5-strain probiotic as well as other supplements. At 3 months, the patient demonstrated improved glycemic control (hemoglobin A1c decreased from 7.2% to 5.9%) and improvement in newly documented mixed hyperlipidemia. At 6 months, testosterone levels normalized with replacement therapy, and the patient achieved modest weight reduction with favorable body composition changes: 13.2-lb decrease in fat mass, as well as a 6.1% reduction in body fat percentage and a 5.1-lb increase in skeletal muscle mass. This case demonstrates the feasibility and clinical efficacy of combining lifestyle interventions with targeted supplementation in a patient with metabolic syndrome who preferred non-pharmacological management strategies.<\/jats:p>","DOI":"10.3389\/fendo.2025.1754430","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T05:39:41Z","timestamp":1768196381000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Lifestyle changes and probiotic supplementation for improving longstanding type 2 diabetes in a male undergoing testosterone replacement 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