{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:04:53Z","timestamp":1792688693799,"version":"4.5.0"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the diagnostic performance of renal function-related indices (blood urea nitrogen (BUN), serum creatinine (sCr), serum uric acid (sUA), serum cystatin C (sCys C)) and the cerebroplacental ratio (CPR) for preeclampsia (PE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a retrospective case-control design, we reviewed the medical records of 172 pregnant women (84 with PE and 88 normotensive controls) who delivered between 2021 and 2024. Independent risk factors were identified using logistic regression, and the Receiver Operating Characteristic (ROC) curve analysis was used to assess the discriminative ability of each parameter for detecting PE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with healthy controls, women with PE exhibited elevated sUA concentrations, greater pre-pregnancy body mass index (BMI), and lower CPR values (all\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05). Multivariable analysis confirmed sUA as an independent predictor of PE, with a substantially increased odds ratio (OR) of 14.082 (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001). ROC curve analysis revealed that sUA had the highest area under the curve (AUC) for diagnosing PE (AUC = 0.837; 95% CI: 0.775-0.899), with a sensitivity of 75.00% and a specificity of 84.09%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among the multiple renal function indices studied, sUA demonstrates the best diagnostic performance for PE and could serve as an effective biomarker for the clinical assessment of PE risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2025.1761526","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:17:39Z","timestamp":1767676659000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Serum uric acid as a diagnostic biomarker for preeclampsia: comparison with renal indices and cerebroplacental ratio"],"prefix":"10.3389","volume":"16","author":[{"given":"Xiaoyan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaimei","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S510654","article-title":"Predictive factors for fetal growth restriction in patients with preeclampsia: A clinical prediction study","volume":"18","author":"Yan","year":"2025","journal-title":"Int J Gen Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1186\/s12884-025-07520-4","article-title":"A nomogram based on peripheral blood count between 12 and 18 weeks of gestation for predicting early-onset preeclampsia in pregnant women: A retrospective case-control study","volume":"25","author":"Xu","year":"2025","journal-title":"BMC Pregnancy Childbirth"},{"key":"B3","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1186\/s12884-025-07733-7","article-title":"Development and validation of a preeclampsia prediction model for the first and second trimester pregnancy based on medical history","volume":"25","author":"Xu","year":"2025","journal-title":"BMC Pregnancy Childbirth"},{"key":"B4","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1186\/s12884-025-07517-z","article-title":"Predictive value of maternal serum placental growth factor, maternal clinical features, and fetal ultrasound indicators in preeclampsia","volume":"25","author":"Ling","year":"2025","journal-title":"BMC Pregnancy Childbirth"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S523131","article-title":"Association between systemic immune-inflammation index in early pregnancy and preeclampsia: A multicenter cohort study","volume":"18","author":"Li","year":"2025","journal-title":"J Inflammation Res"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14020647","article-title":"Evaluation of conventional and combined Doppler parameters in preeclampsia: Diagnostic and prognostic insights","volume":"14","author":"Karabay","year":"2025","journal-title":"J Clin Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015677","article-title":"Hypertensive disorders during pregnancy and elevated blood pressure in the offspring: A systematical review and meta-analysis protocol","volume":"98","author":"Yu","year":"2019","journal-title":"Med (Baltimore)"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.12.001","article-title":"Preeclampsia and eclampsia: The conceptual evolution of a syndrome","volume":"226","author":"Erez","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.19027","article-title":"The relationship between renal function indicators and preeclampsia in the second trimester of pregnancy: A retrospective study","volume":"13","author":"Li","year":"2025","journal-title":"PeerJ"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.62347\/HBLW4532","article-title":"Correlation of uric acid and lipid levels with preeclampsia and final pregnancy outcome in late pregnancy","volume":"17","author":"Dong","year":"2025","journal-title":"Am J Transl Res"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1297731","article-title":"Pre-pregnancy body mass index combined with peripheral blood plgf, dcn, ldh, and ua in a risk prediction model for preeclampsia","volume":"14","author":"Zhou","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-022-01115-8","article-title":"Association of first trimester serum uric acid with preeclampsia: An observational cohort study with propensity score matching","volume":"46","author":"Yue","year":"2023","journal-title":"Hypertens Res"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.23659","article-title":"A new doppler index, cerebro-placental-uterine ratio, and fetal cardiac parameters in early onset preeclampsia","volume":"52","author":"Oguz","year":"2024","journal-title":"J Clin Ultrasound"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.18502\/ijrm.v17i7.4857","article-title":"The relationship between body mass index and preeclampsia: A systematic review and meta-analysis","volume":"17","author":"Motedayen","year":"2019","journal-title":"Int J Reprod Biomed"},{"key":"B15","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1186\/s12884-025-07848-x","article-title":"Correlation between fetal-placental doppler indices and maternal cardiac function in pregnant women with late-onset preeclampsia or fetal growth restriction","volume":"25","author":"Chen","year":"2025","journal-title":"BMC Pregnancy Childbirth"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.placenta.2022.02.015","article-title":"Relationship between placental elastography, maternal pre-pregnancy body mass index and gestational weight gain","volume":"121","author":"Edwards","year":"2022","journal-title":"Placenta"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.911975","article-title":"Development and validation of multi-stage prediction models for preeclampsia: A retrospective cohort study on chinese women","volume":"10","author":"Tang","year":"2022","journal-title":"Front Public Health"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3390\/cells11040633","article-title":"Glucose transporter 9 (GLUT9) plays an important role in the placental uric acid transport system","volume":"11","author":"Luscher","year":"2022","journal-title":"Cells"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.14022","article-title":"Maternal uric acid levels and risk of gestational diabetes mellitus: A systematic review and dose-response meta-analysis of cohort studies including 105,380 participants","volume":"14","author":"Nikparast","year":"2023","journal-title":"J Diabetes Investig"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101435","article-title":"Association of gamma-glutamyltransferase levels with total mortality, liver-related and cardiovascular outcomes: A prospective cohort study in the uk biobank","volume":"48","author":"Ho","year":"2022","journal-title":"EClinicalMedicine"},{"key":"B21","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13098-023-00997-z","article-title":"Association between serum uric acid levels and long-term mortality of metabolic dysfunction-associated fatty liver disease: A nationwide cohort study","volume":"15","author":"Liu","year":"2023","journal-title":"Diabetol Metab Syndr"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.23360","article-title":"Role of salivary uric acid versus serum uric acid in predicting maternal complications of preeclampsia in a rural hospital in central India: A two-year, cross-sectional study","volume":"14","author":"Madaan","year":"2022","journal-title":"Cureus"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2022.2036620","article-title":"Research progress on related mechanisms of uric acid activating nlrp3 inflammasome in chronic kidney disease","volume":"44","author":"Wang","year":"2022","journal-title":"Ren Fail"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3390\/cells12091341","article-title":"Oxidative stress and microRNAs in endothelial cells under metabolic disorders","volume":"12","author":"Minjares","year":"2023","journal-title":"Cells"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/ma13225173","article-title":"Synthesis of nylon 6\/modified carbon black nanocomposite for application in uric acid adsorption","volume":"13","author":"Andrade-Chavez","year":"2020","journal-title":"Materials (Basel)"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/8080578","article-title":"Correlation analysis between uric acid and metabolic syndrome in the chinese elderly population: A cross-sectional study","volume":"2023","author":"Nie","year":"2023","journal-title":"Int J Endocrinol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioaa178","article-title":"Altered expression of adm and adm2 by hypoxia regulates migration of trophoblast and hla-g expressiondagger","volume":"104","author":"Gu","year":"2021","journal-title":"Biol Reprod"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.862716","article-title":"The mechanism of downregulation of twist1 inhibiting trophoblast invasion and aggravating the development of preeclampsia","volume":"9","author":"Yang","year":"2022","journal-title":"Front Surg"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1761526\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:17:40Z","timestamp":1767676660000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1761526\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,6]]},"references-count":28,"alternative-id":["10.3389\/fendo.2025.1761526"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2025.1761526","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,6]]},"article-number":"1761526"}}