{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T22:46:45Z","timestamp":1789339605311,"version":"build-2803163510"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Currently, systemic inflammation indices and insulin resistance are both recognised as high-risk factors for venous thromboembolic diseases. However, there is a lack of research on the relationship between the triglyceride-glucose-systemic inflammation index (TyG-SII) and the risk of lower limb deep vein thrombosis (DVT) in populations with traumatic fractures. This study aims to investigate the relationship between TyG-SII and the risk of DVT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study participants were inpatients from the Orthopaedic Centre of Foshan Traditional Chinese Medicine Hospital. Participants were divided into three groups using K-means clustering analysis based on changes in TyG-SII. Multivariate binary logistic regression analysis was used to explore the association between different groups (based on different levels of TyG-SII and DVT. Restricted cubic spline (RCS) regression models were used to explore the potential nonlinear association between TyG-SII and DVT events. Receiver operating characteristic (ROC) curves were employed to quantify the predictive ability of TyG-SII for DVT. Subgroup analyses further confirmed the relationship between TyG-SII and DVT in different populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 5,455 patients, 1,991 (36.50%) developed DVT, and 646 (11.84%) developed only MCVT. After adjusting for various potential confounding factors, patients with moderate (OR = 0.86, 95% CI: 0.66\u20130.98) and high levels of TyG-SII had a significantly lower risk of DVT compared to those with low levels of TyG-SII (OR = 0.73, 95% CI: 0.58\u20130.95). Compared with the lowest quartile (Q1) of baseline TyG-SII, the third quartile (Q3) showed the most significant protective effect (OR = 0.46, 95% CI: 0.39\u20130.55). Additionally, there was a nonlinear U-shaped relationship between baseline TyG-SII and DVT risk, with thresholds of 242.14 and 3710.98, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For patients with traumatic fractures, TyG-SII is independently associated with the risk of lower limb DVT. Maintaining a good TyG-SII index helps prevent the occurrence of DVT after traumatic fractures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1700809","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:27:47Z","timestamp":1773293267000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between triglyceride glucose- systemic immune inflammation index and deep venous thrombosis in fresh fracture patient: a real-world retrospective study"],"prefix":"10.3389","volume":"17","author":[{"given":"He","family":"Chen","sequence":"first","affiliation":[{"name":"The Eighth Clinical Medical College of Guangzhou University of Chinese Medicine\/Foshan Hospital of Traditional Chinese Medicine","place":["Foshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Chen","sequence":"additional","affiliation":[{"name":"The Eighth Clinical Medical College of Guangzhou University of Chinese Medicine\/Foshan Hospital of Traditional Chinese Medicine","place":["Foshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewen","family":"Xie","sequence":"additional","affiliation":[{"name":"The Eighth Clinical Medical College of Guangzhou University of Chinese Medicine\/Foshan Hospital of Traditional Chinese Medicine","place":["Foshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Lin","sequence":"additional","affiliation":[{"name":"The Eighth Clinical Medical College of Guangzhou University of Chinese Medicine\/Foshan Hospital of Traditional Chinese Medicine","place":["Foshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidan","family":"Yuan","sequence":"additional","affiliation":[{"name":"The Eighth Clinical Medical College of Guangzhou University of Chinese Medicine\/Foshan Hospital of Traditional Chinese 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