{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:27:11Z","timestamp":1770812831927,"version":"3.50.1"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Global aging elevates the incidence of thoracolumbar fragility fractures (TLFFs), which are linked to osteoporosis. Platelets (PLT) and albumin influence bone health; the platelet-to-albumin ratio (PAR) is applied in multi-disease research, but it has not yet been applied to patients with TLFF. This study thus explores PAR\u2019s association with bone mineral density (BMD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cross-sectional analysis based on a cohort of TLFF patients included 703 elderly TLFF patients from Huizhou First Hospital (2020\u20132025). BMD was measured, PAR calculated, and grouped; covariates were collected. Subsequently, characterization of the study population, univariate linear regression analyses, and subgroup as well as interaction analyses were carried out.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>High-PAR groups had higher PLT, lower albumin, and lower BMD. PAR showed a significant negative association with total spine BMD (TS-BMD) even after adjustment; the initial association of neutrophill-to-albumin ratio (NPAR) became non-significant post-adjustment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In elderly TLFF patients, PAR is negatively associated with TS-BMD. As an easily measurable index, PAR may act as a clinical tool.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1717807","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T05:31:39Z","timestamp":1770787899000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between platelet-to-albumin ratio and total spine bone mineral density in older adults with thoracolumbar fragility fractures: a retrospective cross-sectional 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