{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:45:46Z","timestamp":1770813946343,"version":"3.50.1"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare pregnancy and neonatal outcomes between time-lapse and conventional embryo culture in frozen embryo transfer (FET) cycles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary-care academic medical center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>This retrospective cohort study included 15,697 women who underwent single blastocyst transfer during their first FET cycle from January 2017 to December 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention(s)<\/jats:title>\n                    <jats:p>None.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measure(s)<\/jats:title>\n                    <jats:p>The pregnancy outcomes and the neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result(s)<\/jats:title>\n                    <jats:p>Our study demonstrated that pregnancy outcomes were comparable between the time-lapse embryo culture group and the conventional embryo culture group, including biochemical pregnancy (relative risk [RR] = 1.02; 95% confidence interval [CI], 0.92\u20131.13), clinical pregnancy (RR = 1.07; 95% CI: 0.96\u20131.18), ectopic pregnancy (RR = 0.65; 95% CI: 0.37\u20131.17), miscarriage (RR = 0.99; 95% CI: 0.86\u20131.16), live birth (RR = 1.07; 95% CI: 0.98\u20131.18) and multiple live births (RR = 0.94; 95% CI: 0.57\u20131.54). Additionally, no statistically significant differences were observed in neonatal outcomes, including cesarean delivery, male gender, very preterm birth, preterm birth, very low birth weight, low birth weight) or high birth weight. Similarly, there were no statistically significant differences in either gestational age or birth weight between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion(s)<\/jats:title>\n                    <jats:p>Our study demonstrated that time-lapse embryo culture yields comparable pregnancy and neonatal outcomes to conventional embryo culture, suggesting that this technology is both effective and safe for embryo incubation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1722638","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T05:44:19Z","timestamp":1770788659000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pregnancy and neonatal outcomes following time-lapse versus conventional embryo culture: a retrospective cohort study"],"prefix":"10.3389","volume":"17","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaomiao","family":"Xin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juanzi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2022.02.015","article-title":"Noninvasive embryo evaluation and selection by time-lapse monitoring vs. conventional morphologic assessment in women undergoing in vitro fertilization\/intracytoplasmic sperm injection: a single-center randomized controlled study","volume":"117","author":"Meng","year":"2022","journal-title":"Fertil Steril"},{"key":"B2","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.rbmo.2019.10.003","article-title":"\u2018There is only one thing that is truly important in an IVF laboratory: everything\u2019 Cairo Consensus Guidelines on IVF Culture Conditions","volume":"40","author":"Consensus Group","year":"2020","journal-title":"Reprod Biomed Online"},{"key":"B3","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.rbmo.2019.02.009","article-title":"Controversies in ART: considerations and risks for uninterrupted embryo culture","volume":"39","author":"Swain","year":"2019","journal-title":"Reprod Biomed Online"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(23)00168-x","article-title":"Clinical outcomes of uninterrupted embryo culture with or without time-lapse-based embryo selection versus interrupted standard culture (SelecTIMO): a three-armed, multicentre, double-blind, randomised controlled trial","volume":"401","author":"Kieslinger","year":"2023","journal-title":"Lancet (London England)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"Cd011320","DOI":"10.1002\/14651858.CD011320.pub4","article-title":"Time-lapse systems for embryo incubation and assessment in assisted reproduction","volume":"5","author":"Armstrong","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"B6","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.fertnstert.2017.06.031","article-title":"Obstetric and perinatal outcomes of pregnancies conceived with embryos cultured in a time-lapse monitoring system","volume":"108","author":"Insua","year":"2017","journal-title":"Fertil Steril"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.794601","article-title":"Can time-lapse incubation and monitoring be beneficial to assisted reproduction technology outcomes? 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