{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:51:43Z","timestamp":1792601503788,"version":"4.5.0"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Hashimoto\u2019s thyroiditis (HT) is a chronic autoimmune thyroiditis characterized by thyroid-specific autoantibodies (TPOAb, TGAb) positivity and lymphocytic infiltration, and is a major cause of hypothyroidism in iodine-sufficient regions. Epidemiological data show a significant increase in the prevalence of HT, which is about four times more common in adult women than in men. The pathogenesis of HT involves a complex interaction of genetic susceptibility, environmental factors, and immune regulation. Its clinical diagnosis is mainly based on serological tests (TPOAb\/TGAb) and thyroid ultrasound features. The current treatment of Hashimoto\u2019s is based on levothyroxine (T4) replacement. This article presents a narrative review of the pathogenesis, status, and challenges of treatment of HT to provide a theoretical basis for optimizing clinical practice and basic research.<\/jats:p>","DOI":"10.3389\/fendo.2026.1729316","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T06:31:10Z","timestamp":1770013870000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Hashimoto\u2019s thyroiditis: from pathogenesis to clinical management"],"prefix":"10.3389","volume":"17","author":[{"given":"Linghui","family":"Wang","sequence":"first","affiliation":[{"name":"Graduate Joint Training Base of Zhejiang Chinese Medical University (Lishui Joint Training Base - Lishui Municipal Central Hospital)","place":["Hangzhou, Zhejiang, China"]},{"name":"Department of Head and Neck Surgery, The Fifth Hospital Affiliated to Wenzhou Medical University, Lishui Central Hospital","place":["Lishui, 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