{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:24:45Z","timestamp":1790220285245,"version":"4.1.0"},"reference-count":98,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Hemochromatosis-associated arthropathy is a progressive degenerative joint disease characterized by iron-overload related pathological changes. While it may involve episodic inflammatory flares, it is primarily defined by bone and cartilage destruction rather than persistent chronic synovitis. It is typically classified as either spontaneous or secondary. This condition is often accompanied by various clinical manifestations, including liver disease, cardiomyopathy, skin pigmentation changes, diabetes mellitus, erectile dysfunction, and hypothyroidism. Diagnosis typically relies on a combination of imaging techniques such as x-ray, computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound, along with iron function tests and joint fluid analysis. Genetic testing may also serve as an adjunctive diagnostic tool. The main treatment modalities currently available include phlebotomy (the primary therapy for hereditary hemochromatosis), iron chelators, joint cavity drug injections, and surgical interventions. Lastly, we delve into the preventative measures that can be adopted to mitigate the risk of developing this disease.<\/jats:p>","DOI":"10.3389\/fendo.2026.1735750","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:39:08Z","timestamp":1773812348000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Hemochromatosis osteoarthritis"],"prefix":"10.3389","volume":"17","author":[{"given":"Yunze","family":"Yang","sequence":"first","affiliation":[{"name":"Orthopedics and Traumatology, Heilongjiang University of Chinese Medicine","place":["Harbin, Heilongjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyue","family":"Zu","sequence":"additional","affiliation":[{"name":"Puyang Traditional Chinese Medicine Hospital","place":["Puyang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Huang","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine","place":["Harbin, Heilongjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"18016","DOI":"10.1038\/nrdp.2018.16","article-title":"Haemochromatosis","volume":"4","author":"Brissot","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01315-X","article-title":"Haemochromatosis","volume":"388","author":"Powell","year":"2016","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1483-5","article-title":"Total ankle arthroplasty in patients with hereditary hemochromatosis","volume":"469","author":"Barg","year":"2011","journal-title":"Clin Orthop"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1272\/jnms.JNMS.2021_88-306","article-title":"Hemochromatosis and hepatocellular carcinoma secondary to immunoglobulin G4-related disease with hepatopathy: A case report","volume":"88","author":"Kanaka","year":"2021","journal-title":"J Nippon Med School = Nippon Ika Daigaku zasshi vol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.14736","article-title":"Hemochromatosis as a secondary condition to systemic lupus erythematosus: A case report","volume":"26","author":"Liu","year":"2023","journal-title":"Int J rheumatic Dis vol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V8.9.824.824","article-title":"Secondary hemochromatosis. 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