{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T07:32:44Z","timestamp":1793518364627,"version":"4.5.0"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Thyroid disease with retrosternal extension lacks a universally accepted definition in the literature, contributing to significant variability in the reported prevalence across series. This study aims to present the experience of a high-volume center in the management of retrosternal thyroid pathology and to identify potential predictive factors that may assist in surgical planning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Between 1 January 2014 and 31 December 2024 we performed 1347 thyroidectomies: 355 (26,3%) thyroid surgical procedures were performed in patients whose thyroid pathology was identified intra-operatively as retrosternal extension. We analyzed patient comorbidities, any pre-operative treatments, pre-operative imaging, the type of surgical procedure performed, the surgical approach adopted, and post-operative complications. Four definitions of retrosternal thyroid pathology, selected among those most frequently cited in the literature and deemed applicable in clinical practice, were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Benign retrosternal goiter accounted for 84.2% of cases, thyroid malignancies represented 6.2% of the cohort, while retrosternal goiters with indeterminate cytology comprised 9.6% of the total. Total thyroidectomy was performed in 80% of patients. Among the 355 patients operated on, a classical cervical approach (Kocher incision, optionally with split cutaneous layer) was used in 99.2% of cases; only 0.8% required an additional thoracic approach. Pre-operative diagnosis of malignancy and the type of surgical procedure performed emerged as the principal factors associated with the development of recurrent laryngeal nerve palsy and hypocalcaemia in the postoperative period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A universally recognized definition of retrosternal thyroid pathology remains elusive. In high-volume centers the cervical approach is sufficient and the rates of thoracic surgical approach is less than 1%. Computed tomography (CT) or magnetic resonance imaging (MRI) of the cervical region are the modalities of choice for investigating the retrosternal component of the thyroid, as they allow accurate assessment of mediastinal extension and facilitate surgical planning. In our study, the integration of the Huins classification and the Cohen &amp;amp; Cho classification proved to be a valid predictive factor for identifying cases that may require a surgical approach beyond the classical Kocher-type cervicotomy. We recommend that retrosternal thyroid pathologies be managed in referral centers equipped with multidisciplinary expertise and adequate surgical experience to ensure optimal outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1739552","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:25:02Z","timestamp":1772169902000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Surgical management of retrosternal thyroid disease: a decennial retrospective analysis"],"prefix":"10.3389","volume":"17","author":[{"given":"Francesco","family":"Quaglino","sequence":"first","affiliation":[{"name":"General Surgery Division, Maria Vittoria Hospital","place":["Azienda Sanitaria Locale (ASL) Citt\u00e0 di Torino, Turin, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Galetta","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Division, San Giovanni Bosco Hospital","place":["Azienda Sanitaria Locale (ASL) Citt\u00e0 di Torino, Turin, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Cestino","sequence":"additional","affiliation":[{"name":"General Surgery Division, Maria Vittoria Hospital","place":["Azienda Sanitaria Locale (ASL) Citt\u00e0 di Torino, Turin, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Festa","sequence":"additional","affiliation":[{"name":"General Surgery Division, Maria Vittoria Hospital","place":["Azienda Sanitaria Locale (ASL) Citt\u00e0 di Torino, Turin, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ruscio","sequence":"additional","affiliation":[{"name":"General Surgery Division, Maria Vittoria 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Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuela","family":"Cannazza","sequence":"additional","affiliation":[{"name":"General Surgery Division, Maria Vittoria Hospital","place":["Azienda Sanitaria Locale (ASL) Citt\u00e0 di Torino, Turin, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2007.02.003","article-title":"A new classification system for retrosternal goitre based on a systematic review of its complications and management","volume":"6","author":"Huins","year":"2008","journal-title":"Int J Surg"},{"key":"B2","doi-asserted-by":"publisher","first-page":"21","DOI":"10.14744\/SEMB.2022.56514","article-title":"Non-toxic multinodular goiter: from etiopathogenesis to treatment","volume":"56","author":"Unl\u00fc","year":"2022","journal-title":"Sisli Etfal Hastan Tip 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