{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T17:49:34Z","timestamp":1769622574876,"version":"3.49.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017591","name":"Magyar Diabetes T\u00e1rsas\u00e1g","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017591","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Diabetic neuropathy may present with a wide spectrum of sensory manifestations in the oral cavity, ranging from increased sensitivity to pain to impaired nociception. Early detection is crucial, since the changes have significant effects on dental treatment, patient safety and quality of life. We describe two contrasting pictures of patients with diabetes mellitus with signs of oral sensory neuropathy. The first case was a 14-year-old female with poorly controlled type 1 diabetes mellitus (T1DM) presenting with chronic carious lesions, gingivitis, and angular cheilitis. She also had amplified pain reactions to dental procedures despite adequate local anaesthesia and quantitative sensory testing revealed hyperaesthesia related to early diabetic neuropathy. The second patient was a 55-year-old male with a long-term history of type 2 diabetes mellitus (T2DM) with chronic periodontitis and reduced oral sensitivity. He complained of hypoesthesia and reduced pain perception during dental procedures with evidence of established neuropathic involvement. These cases illustrate the broad spectrum of clinical manifestations of diabetic sensory neuropathy in stomatology from early hyperaesthesia in a child with T1DM to late hypoesthesia in an adult with T2DM and illustrate the importance of metabolic control, interdisciplinary collaboration and individualised diagnostic and therapeutic strategies in dentistry.<\/jats:p>","DOI":"10.3389\/fendo.2026.1741118","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T05:22:08Z","timestamp":1769577728000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Early hyperaesthesia and late hypoaesthesia as manifestations of sensory neuropathy in dentistry \u2013 two case reports"],"prefix":"10.3389","volume":"17","author":[{"given":"Laura","family":"Lipt\u00e1k","sequence":"first","affiliation":[{"name":"Department of Paediatric Dentistry and Orthodontics, Semmelweis University","place":["Budapest, Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaudia","family":"Lipt\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Semmelweis University","place":["Budapest, Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Kempler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Oncology, Semmelweis University, Faculty of Medicine","place":["Budapest, Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Hermann","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Semmelweis University","place":["Budapest, Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"No\u00e9mi Katinka","family":"R\u00f3zsa","sequence":"additional","affiliation":[{"name":"Department of Paediatric Dentistry and Orthodontics, Semmelweis University","place":["Budapest, Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gergely","family":"Balaton","sequence":"additional","affiliation":[{"name":"Department of Paediatric Dentistry and Orthodontics, Semmelweis University","place":["Budapest, Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e1niel","family":"V\u00e9gh","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Semmelweis University","place":["Budapest, Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrienn","family":"Menyh\u00e1rt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Oncology, Semmelweis University, Faculty of Medicine","place":["Budapest, Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"K\u00f6rei","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Oncology, Semmelweis University, Faculty of Medicine","place":["Budapest, Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00f3ra Marietta","family":"Balogh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Oncology, Semmelweis University, Faculty of Medicine","place":["Budapest, Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorottya","family":"B\u00e1nyai","sequence":"additional","affiliation":[{"name":"Department of Paediatric Dentistry and Orthodontics, Semmelweis University","place":["Budapest, Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaf177","article-title":"IDF diabetes atlas 11th edition 2025: global prevalence and projections for 2050","author":"Duncan","year":"2025","journal-title":"Nephrol Dial Transplant"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19010545","article-title":"Oral health status of children living with type 1 diabetes mellitus","volume":"19","author":"Banyai","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-014-0473-5","article-title":"Diabetic neuropathy: mechanisms, emerging treatments,\u00a0and subtypes","volume":"14","author":"Albers","year":"2014","journal-title":"Curr Neurol Neurosci Rep"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.4103\/1319-1683.78636","article-title":"Periodontal disease. 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