{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T02:22:22Z","timestamp":1793758942069,"version":"4.6.1"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The temporal dynamics of sleep disturbances following radioactive iodine (RAI) therapy for differentiated thyroid cancer (DTC), along with their underlying mechanisms and associated factors, remain poorly understood. This gap underscores the need for longitudinal investigations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a longitudinal study of 160 DTC patients from Guangdong Southern Teaching Hospital. Self-assessment scales were used to assess patients\u2019 knowledge of the purpose of \u00b9\u00b3\u00b9I therapy, depression, anxiety symptom and sleep assessment scales were used to assess with the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Self-Rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS). Assessments were conducted at three time points: pre-therapy, peri-therapy (during hospitalization), and post-therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 160 patients, 148 completed the study (53 males [35.8%]; 95 females [64.2%]). Risk factors associated with sleep disorders included anxiety, snoring, educational level, and work\/study-related stress. Longitudinal trajectory analysis revealed nonlinear trends: the incidence of sleep disorders (35.8% \u2192 52.9% \u2192 32.6%), anxiety symptoms (23.6% \u2192 40.7% \u2192 14.0%), and depressive symptoms (47.3% \u2192 56.4% \u2192 33.3%) all increased initially before declining.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>With increasing treatment duration, the incidence of sleep disorders, anxiety, and depression initially rose and subsequently declined. Sleep quality reached its lowest point at the end of treatment, whereas anxiety and depression levels peaked one month post-therapy before decreasing to levels below the pre-treatment baseline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1743676","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T05:15:56Z","timestamp":1770009356000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["The relationship between sleep disturbances, depression and anxiety in differentiated thyroid cancer patients during radioiodine (131I) therapy: a longitudinal observational study"],"prefix":"10.3389","volume":"17","author":[{"given":"Wanmin","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Oncology, The Affiliated Panyu Central Hospital, Guangzhou Medical University","place":["Guangzhou, Guandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Interventional Center, Maoming People's Hospital","place":["Maoming, Guandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, The Affiliated Panyu Central Hospital, Guangzhou Medical University","place":["Guangzhou, Guandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunliu","family":"Luo","sequence":"additional","affiliation":[{"name":"Medical Imaging Center, The First Affiliated Hospital, Jinan University","place":["Guangzhou, Guandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-022-01751-4","article-title":"Sleep quality, stress and thyroid cancer: a case-control study","volume":"45","author":"Afrashteh","year":"2022","journal-title":"J Endocrinol Invest"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2023.0090","article-title":"Dysfunction of the salivary and lacrimal glands after radioiodine therapy for thyroid cancer: results of the START study after 6-months of follow-up","volume":"33","author":"Baudin","year":"2023","journal-title":"Thyroid"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/1717119","article-title":"Short-term postoperative depression and anxiety in patients with differentiated thyroid carcinoma: assessment of potential oncologic-psycho relevance","volume":"2024","author":"Chen","year":"2024","journal-title":"Int J Endocrinol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1611(199811\/12)7:6<483::AID-PON326>3.0.CO;2-M","article-title":"Use of the Zung Self-Rating Depression Scale in cancer patients: feasibility as a screening tool","volume":"7","author":"Dugan","year":"1998","journal-title":"Psychooncology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"197","DOI":"10.20945\/2359-3997000000538","article-title":"Radioiodine (131I) treatment decision-making for low- and intermediate-risk differentiated thyroid cancer","volume":"67","author":"Gao","year":"2023","journal-title":"Arch Endocrinol Metab"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-022-07225-w","article-title":"Prevalence and predictors of psychological distress among patients with thyroid cancer during transitional period in China: a cross-sectional study","volume":"30","author":"Gao","year":"2022","journal-title":"Sup. 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