{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:36:48Z","timestamp":1790012208646,"version":"4.0.1"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To quantitatively examine immune cell markers and spatial distribution in human diabetic kidney disease (DKD) to enhance understanding of the inflammatory landscape contributing to injury. Maladaptive inflammation is an underrecognized contributor to DKD pathogenesis and progression and remains undertreated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>NanoString GeoMx\u2122 Digital Spatial Profiling technology targeted antibodies labeled with unique oligonucleotide barcode in kidney biopsy [DKD (n=5), tubulointerstitial nephritis (TIN; n=4), and normal (n=2)] with regions of interest selection of compartments (glomeruli, tubules, interstitium). Inflammation-related proteins were analyzed with differential expression through linear mixed modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to normal tissue, inflammatory cell surface protein markers were increased in DKD tubules and interstitium. Markers of T cells (CD4, CD44), macrophages (CD68; proinflammatory), and antigen-presenting cells (APCs; CD40 and CD11c) were increased across all DKD compartments (vs. normal). Macrophage (CD163; prorepair) marker was increased in DKD tubules and interstitium (vs. normal). Fewer differences were observed in glomeruli for normal vs. DKD or TIN vs. DKD groups. CD66b+ (granulocytes) cell marker was higher in DKD (vs. TIN). As expected, TIN had higher levels of T cell and macrophage markers in tubules and interstitium (vs. DKD). Interestingly, CD34, a hematopoietic stem cell and endothelial cell marker, was lower in DKD tubules and interstitium (vs. normal) but higher in DKD (vs. TIN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NanoString GeoMx DSP technology may fulfil a role in enhancing the understanding the inflammatory landscape engaged in DKD pathogenesis as well as measuring response to therapy. Moreover, additional investigations of CD34 progenitor cell depletion in DKD may be warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1744430","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T05:16:25Z","timestamp":1770009385000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Capturing the inflammatory landscape within kidney compartments of human diabetic kidney disease: a digital spatial profiling study"],"prefix":"10.3389","volume":"17","author":[{"given":"Khaled M.","family":"Elhusseiny","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic","place":["Jacksonville, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farha G.","family":"Deceus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mayo Clinic","place":["Scottsdale, AZ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn D.","family":"Cornell","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic","place":["Rochester, MN, United States"]},{"name":"Department of Pathology and Laboratory Medicine, University of Calgary","place":["Calgary, AB, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Bian","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic","place":["Jacksonville, FL, United States"]},{"name":"Department of Nephrology, Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaohua","family":"Ma","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics, Mayo Clinic","place":["Jacksonville, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Kachergus","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Mayo Clinic","place":["Jacksonville, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Aubrey","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Mayo Clinic","place":["Jacksonville, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LaTonya J.","family":"Hickson","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic","place":["Jacksonville, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2017.10.011","article-title":"The global epidemiology of diabetes and kidney disease","volume":"25","author":"Koye","year":"2018","journal-title":"Adv Chronic Kidney Dis"},{"key":"B2","doi-asserted-by":"publisher","first-page":"109119","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res Clin Pract"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11491116","article-title":"Diabetic kidney disease: challenges, progress, and possibilities","volume":"12","author":"Alicic","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1708949","article-title":"A new chapter for diabetic kidney disease","volume":"377","author":"de Boer","year":"2017","journal-title":"N Engl J Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30772-X","article-title":"Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial","volume":"393","author":"Heerspink","year":"2019","journal-title":"Lancet"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2017.12.002","article-title":"Inflammatory mechanisms as new biomarkers and therapeutic targets for diabetic kidney disease","volume":"25","author":"Alicic","year":"2018","journal-title":"Adv Chronic Kidney Dis"},{"key":"B7","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.semnephrol.2010.03.007","article-title":"Macrophages and diabetic nephropathy","volume":"30","author":"Tesch","year":"2010","journal-title":"Semin Nephrol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000754","article-title":"Fortifying the diabetic kidney disease treatment armamentarium: multitarget senotherapeutic and regenerative strategies","volume":"36","author":"Patel","year":"2025","journal-title":"J Am Soc Nephrol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2410659","article-title":"Finerenone with empagliflozin in chronic kidney disease and type 2 diabetes","volume":"393","author":"Agarwal","year":"2025","journal-title":"N Engl J Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1841690","DOI":"10.1155\/2016\/1841690","article-title":"Immune cells and inflammation in diabetic nephropathy","volume":"2016","author":"Zheng","year":"2016","journal-title":"J Diabetes Res"},{"key":"B11","doi-asserted-by":"crossref","DOI":"10.1681\/ASN.2015010111","article-title":"Anti-inflammatory role of microRNA-146a in the pathogenesis of diabetic nephropathy","volume":"27","author":"Bhatt","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0234-4","article-title":"Innate immunity in diabetic kidney disease","author":"Tang","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/sj.ki.5000014","article-title":"Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice","volume":"69","author":"Chow","year":"2006","journal-title":"Kidney Int"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.10.2586","article-title":"Intercellular adhesion molecule-1-deficient mice are resistant against renal injury after induction of diabetes","volume":"52","author":"Okada","year":"2003","journal-title":"Diabetes"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7120468","article-title":"The interaction of miR-378i-skp2 regulates cell senescence in diabetic nephropathy","volume":"7","author":"Tsai","year":"2018","journal-title":"J Clin Med"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2022.08.026","article-title":"The single-cell landscape of kidney immune cells reveals transcriptional heterogeneity in early diabetic kidney disease","volume":"102","author":"Fu","year":"2022","journal-title":"Kidney Int"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00367.x","article-title":"Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury","volume":"65","author":"Chow","year":"2004","journal-title":"Kidney Int"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060937","article-title":"The role of interstitial macrophages in nephropathy of type 2 diabetic db\/db mice","volume":"170","author":"Ninichuk","year":"2007","journal-title":"Am J Pathol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1159\/000334928","article-title":"Aberrant recruitment and activation of T cells in diabetic nephropathy","volume":"35","author":"Moon","year":"2012","journal-title":"Am J Nephrol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.2337\/diab.37.5.507","article-title":"Proteinuria and activated T-lymphocytes in diabetic nephropathy","volume":"37","author":"Bending","year":"1988","journal-title":"Diabetes"},{"key":"B21","doi-asserted-by":"crossref","DOI":"10.1042\/CS20160636","article-title":"Diabetic nephropathy \u2013 is this an immune disorder","volume":"131","author":"Tesch","year":"2017","journal-title":"Clin Sci"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.3390\/biomedicines11071889","article-title":"Relationship between macrophages and tissue microenvironments in diabetic kidneys","volume":"11","author":"Yan","year":"2023","journal-title":"Biomedicines"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1084448","article-title":"T cells and their products in diabetic kidney disease","volume":"14","author":"Liu","year":"2023","journal-title":"Front Immunol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh441","article-title":"Macrophages in streptozotocin-induced diabetic nephropathy: potential role in renal fibrosis","volume":"19","author":"Chow","year":"2004","journal-title":"Nephrol Dialysis Transplant"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2006.00576.x","article-title":"Macrophage accumulation in human progressive diabetic nephropathy","volume":"11","author":"Nguyen","year":"2006","journal-title":"Nephrol (Carlton)"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0168-8227(96)01209-0","article-title":"Expression of ICAM-1 on glomeruli is associated with progression of diabetic nephropathy in a genetically obese diabetic rat, Wistar fatty","volume":"32","author":"Matsui","year":"1996","journal-title":"Diabetes Res Clin Pract"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/j.cmet.2022.05.010","article-title":"Mapping the single-cell transcriptomic response of murine diabetic kidney disease to therapies","volume":"34","author":"Wu","year":"2022","journal-title":"Cell Metab"},{"key":"B28","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1038\/s41592-021-01203-6","article-title":"Spatial omics and multiplexed imaging to explore cancer biology","volume":"18","author":"Lewis","year":"2021","journal-title":"Nat Methods"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13174456","article-title":"Best practices for spatial profiling for breast cancer research with the geoMx(\u00ae) digital spatial profiler","volume":"13","author":"Bergholtz","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.990367","article-title":"Location matters: LAG3 levels are lower in renal cell carcinoma metastatic sites compared to primary tumors, and expression at metastatic sites only may have prognostic importance","volume":"12","author":"Schoenfeld","year":"2022","journal-title":"Front Oncol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.890410","article-title":"Challenges and opportunities for immunoprofiling using a spatial high-plex technology: the nanoString geoMx(\u00ae) digital spatial profiler","volume":"12","author":"Hernandez","year":"2022","journal-title":"Front Oncol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.831253","article-title":"Digital spatial profiling of individual glomeruli from patients with anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis","volume":"13","author":"Ye","year":"2022","journal-title":"Front Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"83","DOI":"10.34067\/KID.000461202","article-title":"Digital spatial profiling of glomerular gene expression in pauci-immune focal necrotizing glomerulonephritis","volume":"4","author":"Oszwald","year":"2023","journal-title":"Kidney360"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-0343","article-title":"Characteristics and spatially defined immune (micro)landscapes of early-stage PD-L1-positive triple-negative breast cancer","volume":"27","author":"Carter","year":"2021","journal-title":"Clin Cancer Res"},{"key":"B35","doi-asserted-by":"crossref","first-page":"892","DOI":"10.3389\/fimmu.2017.00892","article-title":"CD56 in the immune system: more than a marker for cytotoxicity","volume":"8","author":"Van Acker","year":"2017","journal-title":"Front Immunol"},{"key":"B36","doi-asserted-by":"crossref","DOI":"10.1093\/ndt\/gfv067","article-title":"Interstitial eosinophilic aggregates in diabetic nephropathy: allergy or not","volume":"30","author":"Dai","year":"2015","journal-title":"Nephrol Dial Transplant"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.101","article-title":"An abundance of IgG4+ plasma cells is not specific for IgG4-related tubulointerstitial nephritis","volume":"24","author":"Houghton","year":"2011","journal-title":"Modern Pathol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/5.1.10","article-title":"Association of glomerular and interstitial mononuclear leukocytes with different forms of glomerulonephritis","volume":"5","author":"Markovic-Lipkovski","year":"1990","journal-title":"Nephrol Dial Transplant"},{"key":"B39","doi-asserted-by":"publisher","first-page":"II29","DOI":"10.1161\/01.HYP.7.6_Pt_2.II29","article-title":"Renal histopathology in hypertensive diabetic patients","volume":"7","author":"Ditscherlein","year":"1985","journal-title":"Hypertension"},{"key":"B40","article-title":"Diabetic nephropathy, inflammation, hyaluronan and interstitial fibrosis","volume":"23","author":"Lewis","year":"2008","journal-title":"Histol Histopathol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1987.93","article-title":"Leukocyte analysis using monoclonal antibodies in human glomerulonephritis","volume":"31","author":"Hooke","year":"1987","journal-title":"Kidney Int"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/146154","article-title":"Inflammation in diabetic nephropathy","volume":"2012","author":"Lim","year":"2012","journal-title":"Mediators Inflammation"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80393-3","article-title":"The role of macrophages in diabetic glomerulosclerosis","volume":"21","author":"Furuta","year":"1993","journal-title":"Am J Kidney Dis"},{"key":"B44","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/BF00192921","article-title":"Acute tubulointerstitial nephritis: phenotype of infiltrating cells and prognostic impact of tubulitis","volume":"428","author":"Iv\u00e1nyi","year":"1996","journal-title":"Virchows Arch"},{"key":"B45","doi-asserted-by":"crossref","DOI":"10.1159\/000314577","article-title":"Pathogenesis of tubular interstitial nephritis","volume-title":"Experimental models for renal diseases: pathogenesis and diagnosis","author":"Tanaka","year":"2011"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-016-1488-4","article-title":"Inflammation, oxidative stress, apoptosis, and autophagy in diabetes mellitus and diabetic kidney disease: the Four Horsemen of the Apocalypse","volume":"49","author":"Turkmen","year":"2017","journal-title":"Int Urol Nephrol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2014.02.007","article-title":"The alteration of Th1\/Th2\/Th17\/Treg paradigm in patients with type 2 diabetes mellitus: Relationship with diabetic nephropathy","volume":"75","author":"Zhang","year":"2014","journal-title":"Hum Immunol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.29074\/ascls.2018000331","article-title":"The role of hyperglycemia in CD4 T cell survival and differentiation","author":"Iwai","year":"2018","journal-title":"Am Soc Clin Lab Sci"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00179.2016","article-title":"Inhibition of T-cell activation by the CTLA4-Fc Abatacept is sufficient to ameliorate proteinuric kidney disease","volume":"312","author":"Herrera","year":"2017","journal-title":"Am J Physiology-Renal Physiol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.2337\/db18-1075","article-title":"LRNA9884, a Novel Smad3-Dependent Long Noncoding RNA, Promotes Diabetic Kidney Injury in db\/db Mice via Enhancing MCP-1-Dependent Renal Inflammation","volume":"68","author":"Zhang","year":"2019","journal-title":"Diabetes"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2018090896","article-title":"Single-cell RNA profiling of glomerular cells shows dynamic changes in experimental diabetic kidney disease","volume":"30","author":"Fu","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1321507","article-title":"Prediction of treatment response in lupus nephritis using density of tubulointerstitial macrophage infiltration","volume":"15","author":"Wang","year":"2024","journal-title":"Front Immunol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv459","article-title":"C-C motif-ligand 2 inhibition with emapticap pegol (NOX-E36) in type 2 diabetic patients with albuminuria","volume":"32","author":"Menne","year":"2017","journal-title":"Nephrol Dial Transplant"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.112737","article-title":"Macrophages in focus: key drivers and therapeutic opportunities in diabetic kidney disease","volume":"21","author":"Zhao","year":"2025","journal-title":"Int J Biol Sci"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2025.05.007","article-title":"Exploring inflammatory and fibrotic mechanisms driving diabetic nephropathy progression","volume":"84","author":"Ansari","year":"2025","journal-title":"Cytokine Growth Factor Rev"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1128134","article-title":"CD34 positive cells as endothelial progenitor cells in biology and medicine","volume":"11","author":"Hassanpour","year":"2023","journal-title":"Front Cell Dev Biol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"5584871","DOI":"10.1155\/2021\/5584871","article-title":"Adenosine A1 receptor deficiency aggravates extracellular matrix accumulation in diabetic nephropathy through disturbance of peritubular microenvironment","volume":"2021","author":"Tian","year":"2021","journal-title":"J Diabetes Res"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2008.02638.x","article-title":"Decreased circulating CD34+ cells are associated with progression of diabetic nephropathy","volume":"26","author":"Makino","year":"2009","journal-title":"Diabetes Med"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90755.2008","article-title":"Endothelial progenitor cell dysfunction in patients with progressive chronic kidney disease","volume":"296","author":"Krenning","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015010006","article-title":"Failed tubule recovery, AKI-CKD transition, and kidney disease progression","volume":"26","author":"Venkatachalam","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-014-0807-x","article-title":"Protective effects of adiponectin on uncoupling of glomerular VEGF-NO axis in earlflammation in diabetic nephropaty streptozotocin-induced type 2 diabetic rats","volume":"46","author":"Hou","year":"2014","journal-title":"Int Urol Nephrol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.7A7354.2008","article-title":"Glomerular CD34 expression in short- and long-term diabetes","volume":"56","author":"Acevedo","year":"2008","journal-title":"J Histochem Cytochem"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1744430\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T09:28:45Z","timestamp":1771925325000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1744430\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,2]]},"references-count":62,"alternative-id":["10.3389\/fendo.2026.1744430"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2026.1744430","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,2]]},"article-number":"1744430"}}