{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:03:18Z","timestamp":1770980598169,"version":"3.50.1"},"reference-count":83,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To elucidate the protective effects of aqueous\n                      <jats:italic>Coriandrum sativum<\/jats:italic>\n                      seed extract against high-fat, high-sugar diet (HSFD)-induced glucolipid metabolic disorder in mice, with particular focus on gut\u2013liver axis regulation involving hepatic metabolism, oxidative stress, inflammation, and gut microbiota composition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Male mice were fed an HSFD and orally treated with\n                      <jats:italic>Coriandrum sativum<\/jats:italic>\n                      seed extract (1.0 or 2.0 g\/kg\/day) for eight weeks. Biochemical parameters, histopathology, hepatic gene expression, oxidative stress markers, and gut microbial profiles were assessed via standard assays, RT-qPCR, Western blot, histological staining, and full-length 16S rRNA gene sequencing with functional prediction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The extract significantly ameliorated HSFD-induced metabolic impairments, including hyperglycemia, hyperlipidemia, insulin resistance, and hepatic steatosis. Histological improvements were observed in the liver, pancreas, and colon. Hepatic expression of FAS, NF-\u03baB, and IL-6 was suppressed, while PPAR\u03b1 and LDLR expression was restored. Antioxidant defenses were enhanced by reducing malondialdehyde and increasing superoxide dismutase activity. Microbiota analysis revealed partial restoration of beneficial taxa such as\n                      <jats:italic>Lactobacillus murinus<\/jats:italic>\n                      and\n                      <jats:italic>Lachnospiraceae<\/jats:italic>\n                      _UCG-006, alongside enrichment of microbial pathways related to energy and carbohydrate metabolism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Aqueous\n                      <jats:italic>Coriandrum sativum<\/jats:italic>\n                      seed extract exerts systemic metabolic benefits in diet-induced glucolipid dysregulation by targeting the gut\u2013liver axis. Its multi-targeted actions on hepatic metabolism, inflammatory signaling, oxidative balance, and gut microbiota composition support its potential as a natural therapeutic agent for metabolic disorders.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1744741","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:03:32Z","timestamp":1770977012000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective role of aqueous Coriandrum sativum seed extract in diet-induced glucolipid metabolic disorder through gut\u2013liver axis regulation"],"prefix":"10.3389","volume":"17","author":[{"given":"Yuru","family":"Xu","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linen","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Wulanna","sequence":"additional","affiliation":[{"name":"Medical Administration Section, Hohhot Hospital of Mongolian and Chinese Medicine","place":["Hohhot, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shutong","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengyi","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengran","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingke","family":"Zhan","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingchun","family":"Wang","sequence":"additional","affiliation":[{"name":"Inner Mongolia Academy of Traditional Chinese and Mongolian Medicine","place":["Hohhot, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chongming","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]},{"name":"Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine","place":["Tianjin, China"]},{"name":"State Key Laboratory of Chinese Medicine Modernization","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms\/150639","article-title":"Non-alcoholic fatty liver disease, metabolic syndrome, and type 2 diabetes mellitus: Where do we stand today","volume":"19","author":"Mitrovic","year":"2022","journal-title":"Arch Med Sci"},{"key":"B2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.2337\/dsi23-0010","article-title":"Understanding the burden of nonalcoholic fatty liver disease: Time for action","volume":"37","author":"Younossi","year":"2024","journal-title":"Diabetes Spectr"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101092","article-title":"Dysregulated lipid metabolism links NAFLD to cardiovascular disease","volume":"42","author":"Deprince","year":"2020","journal-title":"Mol Metab"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1410.035","article-title":"Chronic stress, combined with a high-fat\/high-sugar diet, shifts sympathetic signaling toward neuropeptide Y and leads to obesity and the metabolic syndrome","volume":"1148","author":"Kuo","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"B5","doi-asserted-by":"publisher","first-page":"4409","DOI":"10.1038\/s41467-023-40039-w","article-title":"Determining the metabolic effects of dietary fat, sugars and fat-sugar interaction using nutritional geometry in a dietary challenge study with male mice","volume":"14","author":"Wali","year":"2023","journal-title":"Nat Commun"},{"key":"B6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.immuni.2021.12.013","article-title":"Inflammation in obesity, diabetes and related disorders","volume":"55","author":"Rohm","year":"2022","journal-title":"Immunity"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15046184","article-title":"Obesity and its metabolic complications: The role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease","volume":"15","author":"Jung","year":"2014","journal-title":"Int J Mol Sci"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfutfo.2024.11.014","article-title":"Surfactin alleviates insulin resistance by modulating the AMPK\/PI3K\/akt signalling pathway and inactivating inflammatory pathways","volume":"6","author":"Chen","year":"2025","journal-title":"J Future Foods"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfutfo.2025.07.025","article-title":"Preventive effects of bioactive compounds in blueberries (vaccinium spp.) against chronic diseases and their molecular mechanisms","author":"Arshad","year":"2025","journal-title":"J Future Foods"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.26599\/FMH.2025.9420058","article-title":"The improvement effect of ellagic acid and urolithins on metabolic diseases: Pharmacology and mechanism","volume":"2","author":"Wang","year":"2025","journal-title":"Food Med Homology"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2025.110348","article-title":"The impact of oxidative stress on abnormal lipid metabolism-mediated disease development","volume":"766","author":"Li","year":"2025","journal-title":"Arch Biochem Biophys"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2025.108277","article-title":"Volatile oils of schisandra chinensis (turcz.) baill alleviates parkinson\u2019s disease by activating the Nrf2 pathway to positively regulate autophagy and oxidative stress","volume":"157","author":"Wang","year":"2025","journal-title":"Bioorg Chem"},{"key":"B13","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s12906-025-04858-2","article-title":"Exploring the therapeutic impact of salvia officinalis on lipid and oxidative stress markers in patients with polycystic ovary syndrome \u2013 a randomized placebo-controlled clinical trial","volume":"25","author":"Maleki-Hajiagha","year":"2025","journal-title":"BMC Complement Med Ther"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1039\/d0fo02736g","article-title":"Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K\/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD","volume":"12","author":"Li","year":"2021","journal-title":"Food Funct"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/med4.6","article-title":"Global prevalence of staphylococcus aureus in food products and its relationship with the occurrence and development of diabetes mellitus","volume":"1","author":"Liang","year":"","journal-title":"Med Adv"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/nu15061517","article-title":"Anti-inflammatory effects of lipid-lowering drugs and supplements\u2014a narrative review","volume":"15","author":"Zivkovic","year":"2023","journal-title":"Nutrients"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-024-01628-0","article-title":"Medication-induced hyperglycemia and diabetes mellitus: A review of current literature and practical management strategies","volume":"15","author":"Jain","year":"2024","journal-title":"Diabetes Ther"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5936402","article-title":"Herbal medicines for treating metabolic syndrome: A systematic review of randomized controlled trials","volume":"2016","author":"Jang","year":"2016","journal-title":"Evid Based Complement Alternat Med"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1105405","article-title":"The interplay between herbal medicines and gut microbiota in metabolic diseases","volume":"14","author":"Wang","year":"2023","journal-title":"Front Pharmacol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114538","article-title":"Managing metabolic diseases: The roles and therapeutic prospects of herb-derived polysaccharides","volume":"161","author":"Xu","year":"2023","journal-title":"BioMed Pharmacother"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.26599\/FMH.2025.9420122","article-title":"The fundamental traditional Chinese medicine constitution theory serves as a crucial basis for the development and application of food and medicine homology products","volume":"2","author":"Guo","year":"2025","journal-title":"Food Med Homology"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-024-00513-y","article-title":"Alleviating mitochondrial dysfunction in diabetic cardiomyopathy through the adipsin and Irak2 pathways","volume":"11","author":"Cummins","year":"2024","journal-title":"Mil Med Res"},{"key":"B23","unstructured":"scRiskCell: A single-cell framework for quantifying islet risk cells and their adaptive dynamics in type 2 diabetes - xie\n          \n          2025"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1267677","article-title":"Editorial: Action mechanisms of traditional medicinal plants used to control type 2 diabetes or conditions of metabolic syndrome, volume II","volume":"14","author":"Andrade-Cetto","year":"2023","journal-title":"Front Pharmacol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/nu17050877","article-title":"A narrative review on plant extracts for metabolic syndrome: Efficacy, safety, and technological advances","volume":"17","author":"Ullah","year":"2025","journal-title":"Nutrients"},{"key":"B26","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13073-016-0303-2","article-title":"Impact of the gut microbiota on inflammation, obesity, and metabolic disease","volume":"8","author":"Boulang\u00e9","year":"2016","journal-title":"Genome Med"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28104187","article-title":"Coriander (Coriandrum sativum) polyphenols and their nutraceutical value against obesity and metabolic syndrome","volume":"28","author":"Scandar","year":"2023","journal-title":"Molecules"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.18203\/2319-2003.ijbcp20250496","article-title":"Potential of Coriandrum sativum in management of diabetes and hyperlipidemia: A comprehensive review of pharmacological evidence and mechanisms","volume":"14","author":"SKY","year":"2025","journal-title":"Int J Basic Clin Pharmacol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.51601\/IJHP.V2I1.14","article-title":"Coriander seed extract (coriandum sativum L) as an antioxidant","volume":"2","author":"Pratama","year":"2022","journal-title":"Int J Health Pharm (IJHP)"},{"key":"B30","doi-asserted-by":"crossref","unstructured":"Effectiveness of coriander seed extract in decreasing blood glucose level among diabetic patients\n          \n          \n            \n              Sheela\n              R\n            \n            \n              Sheeba\n              MS\n            \n            \n              Poornima\n            \n            \n              Priya\n            \n          \n          10.26452\/ijrps.v11i3.2367\n          Int J Res Pharm Sci\n          11\n          2020","DOI":"10.26452\/ijrps.v11i3.2367"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26020487","article-title":"Antioxidant, anti-inflammatory and antidiabetic proprieties of LC-MS\/MS identified polyphenols from coriander seeds","volume":"26","author":"Mechchate","year":"2021","journal-title":"Molecules"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.06.120","article-title":"Evaluation of coriander spice as a functional food by using in vitro bioassays","volume":"167","author":"Zhang","year":"2015","journal-title":"Food Chem"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/S0308-8146(99)00113-2","article-title":"Coriandrum sativum \u2014 mechanism of hypoglycemic action","volume":"67","author":"Chithra","year":"1999","journal-title":"Food Chem"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2642","article-title":"Effect of coriander seed (Coriandrum sativum L.) ethanol extract on insulin release from pancreatic beta cells in streptozotocin-induced diabetic rats","volume":"23","author":"Eidi","year":"2009","journal-title":"Phytother Res"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e37609","article-title":"The complex link between the gut microbiome and obesity-associated metabolic disorders: Mechanisms and therapeutic opportunities","volume":"10","author":"Zhang","year":"2024","journal-title":"Heliyon"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-021-00677-w","article-title":"Role of the gut-brain axis in energy and glucose metabolism","volume":"54","author":"Wachsmuth","year":"2022","journal-title":"Exp Mol Med"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00394-017-1445-8","article-title":"Gut microbiota functions: Metabolism of nutrients and other food components","volume":"57","author":"Rowland","year":"2018","journal-title":"Eur J Nutr"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1500453","article-title":"Gut microbiome and NAFLD: Impact and therapeutic potential","volume":"15","author":"Li","year":"2024","journal-title":"Front Microbiol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2025.121186","article-title":"Association between phthalate exposure and metabolic dysfunction-associated steatotic liver disease (MASLD) \u2013 systematic literature review","volume":"273","author":"Gogola","year":"2025","journal-title":"Environ Res"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.2312.12031","article-title":"Diet-induced gut dysbiosis and leaky gut syndrome","volume":"34","author":"Chae","year":"2024","journal-title":"J Microbiol Biotechnol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156118","article-title":"Lignan-rich extract from cinnamomum camphora leaf attenuates metabolic syndrome by modulating glycolipid metabolism and gut microbiota in T2DM mice","volume":"135","author":"Huang","year":"2024","journal-title":"Phytomedicine"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3390\/ph17091131","article-title":"Enhanced anti-obesity effects of euphorbia kansui extract through macrophage and gut microbiota modulation: A real-world clinical and in vivo study","volume":"17","author":"Noh","year":"2024","journal-title":"Pharm (Basel)"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1021\/cr2001355","article-title":"PPARs and lipid ligands in inflammation and metabolism","volume":"111","author":"Harmon","year":"2011","journal-title":"Chem Rev"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27989","article-title":"Sorting out the roles of PPAR\u03b1 in energy metabolism and vascular homeostasis","volume":"116","author":"Lefebvre","year":"2006","journal-title":"J Clin Invest"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59112028","article-title":"In vitro assessment of anti-adipogenic and anti-inflammatory properties of black cumin (nigella sativa L.) seeds extract on 3T3-L1 adipocytes and Raw264.7 macrophages","volume":"59","author":"Bashir","year":"2023","journal-title":"Med (mex)"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123663","article-title":"Olive leaf extract, from olea europaea L., reduces palmitate-induced inflammation via regulation of murine macrophages polarization","volume":"12","author":"De Cicco","year":"2020","journal-title":"Nutrients"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153728","article-title":"Smilax China L. flavonoid alleviates HFHS-induced inflammation by regulating the gut-liver axis in mice","volume":"95","author":"Li","year":"2022","journal-title":"Phytomedicine"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1039\/c8nr00386f","article-title":"Oral administration of rutile and anatase TiO2 nanoparticles shifts mouse gut microbiota structure","volume":"10","author":"Li","year":"2018","journal-title":"Nanoscale"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9734845","article-title":"Phytochemicals that influence gut microbiota as prophylactics and for the treatment of obesity and inflammatory diseases","volume":"2018","author":"Carrera-Quintanar","year":"2018","journal-title":"Mediators Inflammation"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13111386","article-title":"Gut microbiota and metabolic dysfunction-associated steatotic liver disease","volume":"13","author":"Scarpellini","year":"2024","journal-title":"Antioxidants"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108238","article-title":"Bile acid metabolism and signaling, the microbiota, and metabolic disease","volume":"237","author":"Cai","year":"2022","journal-title":"Pharmacol Ther"},{"key":"B52","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.indcrop.2016.04.024","article-title":"Chemical characterization of polyphenols and volatile fraction of coriander (Coriandrum sativum L.) extracts obtained by subcritical water extraction","volume":"87","author":"Zekovi\u0107","year":"2016","journal-title":"Ind Crops Prod"},{"key":"B53","doi-asserted-by":"publisher","first-page":"e035754","DOI":"10.1161\/JAHA.124.035754","article-title":"Associations of placental inflammation and oxidative stress biomarkers with glucolipid metabolism in children: A birth cohort study in China","volume":"13","author":"Zhou","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"B54","doi-asserted-by":"publisher","first-page":"441","DOI":"10.3390\/antiox13111410","article-title":"Coriander oil reverses dexamethasone-induced insulin resistance in rats","volume":"11","author":"Mahmoud","year":"2022","journal-title":"Antioxidants"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2021.03.011","article-title":"Evaluation of the composition and in vitro antimicrobial, antioxidant, and anti-inflammatory activities of cilantro (Coriandrum sativum L. leaves) cultivated in Saudi Arabia (al-kharj)","volume":"28","author":"Foudah","year":"2021","journal-title":"Saudi J Biol Sci"},{"key":"B56","unstructured":"Chemical composition, antioxidant and anti-inflammatory activities of clary sage and coriander essential oils produced on polluted and amended soils-phytomanagement approach"},{"key":"B57","unstructured":"Cyanidin-3-rutinoside from mori fructus ameliorates dyslipidemia via modulating gut microbiota and lipid metabolism pathway"},{"key":"B58","unstructured":"Dendrobium officinale polysaccharide alleviates type 2 diabetes mellitus by restoring gut microbiota and repairing intestinal barrier via the LPS\/TLR4\/TRIF\/NF-kB axis"},{"key":"B59","unstructured":"Coriander: A holistic outlook on its chemistry and pharmacology"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.616219","article-title":"Effect of quercetin on lipids metabolism through modulating the gut microbial and AMPK\/PPAR signaling pathway in broilers","volume":"9","author":"Wang","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-017-0135-4","article-title":"Apigenin attenuates streptozotocin-induced pancreatic \u03b2 cell damage by its protective effects on cellular antioxidant defense","volume":"53","author":"Wang","year":"2017","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8020035","article-title":"Potential role of flavonoids in treating chronic inflammatory diseases with a special focus on the anti-inflammatory activity of apigenin","volume":"8","author":"Ginwala","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175788","article-title":"Oroxin B improves metabolic-associated fatty liver disease by alleviating gut microbiota dysbiosis in a high-fat diet-induced rat model","volume":"951","author":"Huang","year":"2023","journal-title":"Eur J Pharmacol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.140846","article-title":"\u03b2-glucan-based superabsorbent hydrogel ameliorates obesity-associated metabolic disorders via delaying gastric emptying, improving intestinal barrier function, and modulating gut microbiota","volume":"304","author":"Jiang","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/s41392-023-01496-3","article-title":"Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome","volume":"8","author":"Lv","year":"2023","journal-title":"Signal Transduction Targeted Ther"},{"key":"B66","doi-asserted-by":"publisher","first-page":"2448","DOI":"10.1038\/s41467-020-16222-8","article-title":"HIV-associated gut dysbiosis is independent of sexual practice and correlates with noncommunicable diseases","volume":"11","author":"Vujkovic-Cvijin","year":"2020","journal-title":"Nat Commun"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.142558","article-title":"Protective effects of sulforaphene on kidney damage and gut dysbiosis in high-fat diet plus streptozotocin-induced diabetic mice","volume":"469","author":"Zhang","year":"2025","journal-title":"Food Chem"},{"key":"B68","doi-asserted-by":"publisher","first-page":"e0315524","DOI":"10.1128\/spectrum.03155-24","article-title":"Capsiate attenuates atherosclerosis by activating Nrf2\/GPX4 pathway and reshaping the intestinal microbiota in ApoE-\/- mice","volume":"13","author":"Shen","year":"2025","journal-title":"Microbiol Spectr"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3390\/nu15102275","article-title":"Gut microbial metabolite butyrate and its therapeutic role in inflammatory bowel disease: A literature review","volume":"15","author":"Recharla","year":"2023","journal-title":"Nutrients"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.119514","article-title":"Sanye tablet regulates gut microbiota and bile acid metabolism to attenuate hepatic steatosis","volume":"345","author":"Qi","year":"2025","journal-title":"J Ethnopharmacol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.141930","article-title":"Proline rich-39 (PR-39) antimicrobial protein alleviated lipopolysaccharide-induced intestinal barrier dysfunction in piglets by altering intestinal flora associated bile acid metabolism and in turn regulating TGR-5\/NF-\u03baB\/MLCK\/MLC pathway","volume":"307","author":"Liu","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1016\/j.cell.2024.03.014","article-title":"Gut microbiome and metabolome profiling in framingham heart study reveals cholesterol-metabolizing bacteria","volume":"187","author":"Li","year":"2024","journal-title":"Cell"},{"key":"B73","unstructured":"Ginger essential oil and citral ameliorates atherosclerosis in ApoE-\/- mice by modulating trimethylamine-N-oxide and gut microbiota"},{"key":"B74","unstructured":"Predominant gut lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice"},{"key":"B75","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s40168-022-01227-w","article-title":"Lactobacillus murinus alleviate intestinal ischemia\/reperfusion injury through promoting the release of interleukin-10 from M2 macrophages via toll-like receptor 2 signaling","volume":"10","author":"Hu","year":"2022","journal-title":"Microbiome"},{"key":"B76","unstructured":"The controversial role of human gut lachnospiraceae"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2025.106662","article-title":"Lactobacillus fermentum B153 from human colostrum modulates intestinal immunity and gut microbiota in obese mice model","volume":"125","author":"Huang","year":"2025","journal-title":"J Funct Foods"},{"key":"B78","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s40168-023-01552-8","article-title":"Using the collaborative cross to identify the role of host genetics in defining the murine gut microbiome","volume":"11","author":"Nagarajan","year":"2023","journal-title":"Microbiome"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1897212","article-title":"The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health","volume":"13","author":"Nogal","year":"2021","journal-title":"Gut Microbes"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.658354","article-title":"Impact of bacterial metabolites on gut barrier function and host immunity: A focus on bacterial metabolism and its relevance for intestinal inflammation","volume":"12","author":"Gasaly","year":"2021","journal-title":"Front Immunol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.3390\/cells12050793","article-title":"Gut-microbiota-derived metabolites maintain gut and systemic immune homeostasis","volume":"12","author":"Wang","year":"2023","journal-title":"Cells"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2021.05.006","article-title":"Sodium butyrate supplementation inhibits hepatic steatosis by stimulating liver kinase B1 and insulin-induced gene","volume":"12","author":"Zhao","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1002\/elsc.202300016","article-title":"Gut microbiota induced epigenetic modifications in the non-alcoholic fatty liver disease pathogenesis","volume":"24","author":"Tang","year":"2023","journal-title":"Eng Life Sci"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1744741\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:03:37Z","timestamp":1770977017000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1744741\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,13]]},"references-count":83,"alternative-id":["10.3389\/fendo.2026.1744741"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2026.1744741","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,13]]},"article-number":"1744741"}}