{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:20:19Z","timestamp":1773037219449,"version":"3.50.1"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To date, 11 cases of COVID-19-associated newly diagnosed Hashimoto\u2019s thyroiditis (HT) have been reported. To investigate the clinical characteristics and influencing factors of Corona Virus Disease 2019 (COVID-19) complicated by newly diagnosed Hashimoto\u2019s thyroiditis (HT) and to inform clinical management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A total of 369 COVID-19 patients were enrolled and divided into three groups: Negative for Antibodies (NA group, n=288), HT group (n=54), and Thyroid Autoimmune (TA group, n=27). The clinical characteristics and influencing factors of the HT group were analyzed. Data analysis was performed using SPSS 27.0 statistical software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients in the HT group were older than those in the NA group [72.5 (63.5, 79.0) vs. 69 (58.3, 76.0) years, P = 0.031]. Fatigue was significantly more common in the HT group compared to both the TA group and the NA group (53.7% vs. 22.2%, and 53.7% vs. 24.0%, all P&amp;lt;0.001). The incidence rates of subclinical hyperthyroidism and hypothyroidism in the HT group were significantly higher than in the NA group (29.6% vs. 13.9%, P = 0.020; 7.4% vs. 1.7%, P = 0.017). Multivariate analysis identified prolonged viral clearance time (OR = 1.136) as an independent risk factor for COVID-19 complicated by HT. Advanced age (OR = 0.944) and low FT3 (OR = 4.233) were identified as independent risk factors for increased mortality risk in COVID-19 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>COVID-19 patients complicated by HT are typically older, with fatigue being a distinguishing clinical manifestation. They are more prone to thyroid dysfunction, with subclinical hyperthyroidism being the predominant early thyroid function abnormality. Prolonged viral clearance time was identified as a factor associated with newly diagnosed HT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1749196","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:29:44Z","timestamp":1773034184000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Emerging evidence from China indicates SARS- COV-2 may be associated with newly diagnosed Hashimoto\u2019s thyroiditis: a clinical study of 54 patients with COVID-19 complicated by newly diagnosed disease"],"prefix":"10.3389","volume":"17","author":[{"given":"Jingyu","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases of The Second Hospital of Hebei Medical University","place":["Shijiazhuang, Hebei, 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