{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:21:13Z","timestamp":1783405273416,"version":"3.54.6"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate short-term changes in hormonal, bone metabolic, and inflammatory markers after ultrasound-guided microwave ablation (MWA) in patients with hyperparathyroidism (HPT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nineteen patients (14 with primary HPT[PHPT], 5 with secondary HPT[SHPT]) underwent MWA. Serum intact parathyroid hormone (iPTH), calcium, phosphate, alkaline phosphatase (ALP), bone turnover markers [e.g., procollagen type I N-terminal propeptide (PINP), bone-specific ALP (BALP), fibroblast growth factor-23 (FGF-23), etc.], and inflammatory markers [e.g., C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-\u03b1 (TNF-\u03b1), etc.] were measured at baseline, day 1, and month 1 post-ablation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>iPTH and calcium decreased by day 1 (both P &amp;lt; 0.001); iPTH remained reduced at month 1 (P &amp;lt; 0.001), while calcium slightly increased (P\u00a0=\u00a00.046). Phosphate showed a borderline upward trend (P\u00a0=\u00a00.050), and ALP decreased at month 1 (P\u00a0=\u00a00.044). PINP increased at month 1 (P\u00a0=\u00a00.011; day 1 to month 1 P\u00a0=\u00a00.001), BALP trended upward (P\u00a0=\u00a00.112), and FGF-23 declined over time (P\u00a0=\u00a00.015). CRP peaked at day 1 and decreased by month 1 (P\u00a0=\u00a00.036); other cytokines remained unchanged. In PHPT, iPTH and calcium decreased on day 1 (both P \u2264 0.001), PINP increased by month 1 (P\u00a0=\u00a00.013), and FGF-23 declined (P\u00a0=\u00a00.009). In SHPT, trends were directionally similar but not statistically significant; calcium decreased on day 1 (P\u00a0=\u00a00.043) and rebounded by month 1. No severe hypocalcemia occurred; two patients experienced transient hoarseness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Microwave ablation induces rapid biochemical normalization and early skeletal and inflammatory changes in patients with hyperparathyroidism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1763008","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:47:50Z","timestamp":1783403270000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Early endocrine, bone, and inflammatory responses to microwave ablation for hyperparathyroidism: preliminary study"],"prefix":"10.3389","volume":"17","author":[{"given":"Ying","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Interventional Medicine, China-Japan Friendship 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