{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:53:34Z","timestamp":1776401614423,"version":"3.51.2"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>\n                      It is important to clarify the impact of COVID-19 on ART outcomes and to develop evidence-based guidelines for deciding whether to proceed with or cancel\n                      <jats:italic>in vitro<\/jats:italic>\n                      fertility procedures in infected patients. This study aims to clarify the specific impacts of COVID-19 infection on the live birth rates (LBR) and fetal outcomes in patients undergoing fresh embryo transfer (fET) cycles.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study analyzed 1,025 fresh embryo transfer cycles from January 2021 to January 2023. We compared pregnancy and neonatal outcomes between the non-infected group (n=762) and the COVID-19-infected group (n=263). Additionally, we stratified the infected group into subgroups by two criteria: time of infection, with or without fever and partner infection status, and further compared pregnancy outcomes of these subgroups. Univariate and multivariate logistic regression analyses were performed to assess differences in pregnancy and neonatal outcomes between non-infected and COVID-19-infected individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The newborn\u2019s gender, birth height and birth weight were comparable between the infected and uninfected groups. However, the COVID-19 infection group exhibited a lower LBR with an adjusted odds ratio (OR) of 0.655 (95% confidence interval (CI: 0.483 to 0.887;\n                      <jats:italic>P =<\/jats:italic>\n                      0.006) and a higher mid-to-late miscarriage rates with an adjusted OR of 7.929 (95% CI: 2.651 to 23.714;\n                      <jats:italic>P &amp;lt;<\/jats:italic>\n                      0.001) compared with the non-infections group. Stratified analysis showed that infections occurring between 28 and 84 days prior to oocyte retrieval accompanied by fever of \u2265 38.5\u00b0C resulted in a lower LBR (OR: 0.467, 95% CI: 0.290 to 0.752;\n                      <jats:italic>P =<\/jats:italic>\n                      0.002 &amp;lt; 0.025) after Bonferroni\u2019s correction. Additionally, the dual-partner infection group demonstrated a significantly reduced LBR (OR: 0.591, 95% CI: 0.421-0.830;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.002 &amp;lt; 0.025) compared to uninfected controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>COVID-19 infection was associated with a lower LBR in fET cycles, especially when: infection occurred 28\u201384 days before oocyte retrieval with fever \u2265 38.5\u00b0C, or dual-partner were infected. Subsequent multicenter studies enrolling a significantly larger cohort of infected women or couples are essential to validate this finding.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1764229","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:12:22Z","timestamp":1776399142000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of COVID-19 infection on the live birth rate in fresh embryo transfer cycles"],"prefix":"10.3389","volume":"17","author":[{"given":"Dan","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Reproductive Medicine Center, Tang Du Hospital, Fourth Military Medical University","place":["Xi\u2019an, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Reproductive Medicine Center, Tang Du Hospital, Fourth Military Medical University","place":["Xi\u2019an, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Reproductive Medicine Center, Tang Du Hospital, Fourth Military Medical University","place":["Xi\u2019an, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ni","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Reproductive Medicine Center, Tang Du Hospital, Fourth Military Medical University","place":["Xi\u2019an, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Reproductive Medicine Center, Tang Du Hospital, Fourth Military Medical University","place":["Xi\u2019an, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Reproductive Medicine Center, Tang Du Hospital, Fourth Military Medical University","place":["Xi\u2019an, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Reproductive Medicine Center, Tang Du Hospital, Fourth Military Medical University","place":["Xi\u2019an, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Reproductive Medicine Center, Tang Du Hospital, Fourth Military Medical University","place":["Xi\u2019an, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huishou","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xijing Hospital, Fourth Military Medical University","place":["Xi\u2019an, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuqiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Reproductive Medicine Center, Tang Du Hospital, Fourth Military Medical University","place":["Xi\u2019an, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Reproductive Medicine Center, Tang Du Hospital, Fourth Military Medical University","place":["Xi\u2019an, 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