{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:55:24Z","timestamp":1781585724625,"version":"3.54.5"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Worldwide, breast cancer (BRCA) remains the most common cancer among women. Identifying novel biomarkers that not only predict prognosis but also inform therapeutic response is urgently needed. La-related protein 1 (\n                      <jats:italic>LARP1<\/jats:italic>\n                      ), an RNA-binding protein and downstream effector of the PI3K\/AKT\/mTOR pathway, is related to multiple forms of cancer, though its impact on BRCA is not well understood.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a comprehensive investigation of\n                      <jats:italic>LARP1<\/jats:italic>\n                      in BRCA using multi-omics databases, including TCGA, GTEx and HPA. Functional annotations were conducted via STRING, GeneMANIA, and LinkedOmics platforms. The correlation between\n                      <jats:italic>LARP1<\/jats:italic>\n                      and tumor immunity was assessed through TISIDB and CIBERSORT. Experimental validation included RT-PCR, Western blotting, EdU, CCK-8, colony formation, transwell, ROS, JC-1, mPTP, and flow cytometry assays in\n                      <jats:italic>LARP1<\/jats:italic>\n                      -silenced SK-BR-3 and MDA-MB-231 cells, along with animal models and immunofluorescence on BRCA tissue microarrays.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>LARP1<\/jats:italic>\n                      was considerably overexpressed in BRCA tissues compared to normal counterparts and was associated with unfavorable overall and progression-free survival outcomes (OS and PFS). Functional enrichment indicated that\n                      <jats:italic>LARP1<\/jats:italic>\n                      participated in cell cycle progression, mitochondrial homeostasis, and immune modulation. Silencing of\n                      <jats:italic>LARP1<\/jats:italic>\n                      inhibited BRCA cells proliferation, migration, and invasion, and triggered mitochondrial dysfunction. Importantly,\n                      <jats:italic>LARP1<\/jats:italic>\n                      downregulation promoted the polarization of tumor-associated macrophages (TAMs) from the immunosuppressive M2 phenotype to the pro-inflammatory M1 phenotype. In clinical tissues,\n                      <jats:italic>LARP1<\/jats:italic>\n                      expression positively correlated with M2 macrophages and negatively with M1 macrophages.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>LARP1<\/jats:italic>\n                      plays a pivotal oncogenic role in BRCA progression by enhancing cell proliferation and immune evasion through mitochondrial regulation and macrophage polarization. These findings highlight\n                      <jats:italic>LARP1<\/jats:italic>\n                      as a promising a potential therapeutic target, and diagnostic, immunological, prognostic biomarker for BRCA.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1764944","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:29:08Z","timestamp":1781584148000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of LARP1 in breast cancer progression: from prognosis to immune microenvironment remodeling"],"prefix":"10.3389","volume":"17","author":[{"given":"Yangtian","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Breast and Thyroid Gland Surgery, Hunan Provincial Maternal and Child Health Care Hospital","place":["Changsha, Hunan, 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Thyroid Gland Surgery, Hunan Provincial People\u2019s Hospital, The First Affiliated Hospital of Hunan Normal University","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Gland Surgery, Hunan Provincial Maternal and Child Health Care Hospital","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3322\/caac.21763","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2025.02.002","article-title":"Global burden of female breast cancer: new estimates in 2022, temporal trend and future projections up to 2050 based on the latest 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