{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:06:44Z","timestamp":1776722804580,"version":"3.51.2"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>The nephrotoxicity of adefovir dipivoxil (ADV) can induce Fanconi syndrome, which causes hypophosphatemic osteomalacia. We report a case of a 67-year-old postmenopausal woman who had been receiving long-term adefovir dipivoxil therapy for chronic hepatitis B. She presented with severe bone pain and multiple pseudofractures, and was diagnosed with drug-induced hypophosphatemic osteomalacia. Following discontinuation of adefovir and supplementation with vitamin D and phosphate, her biochemical parameters normalized and bone pain significantly improved, indicating that osteomalacia had been essentially corrected. However, although follow-up bone mineral density (BMD) showed significant improvement compared to pretreatment values, it remained markedly below the reference range for age-matched women. Postmenopausal osteoporosis was therefore suspected, and anti-osteoporotic pharmacotherapy was initiated after correction of osteomalacia. This case suggests that BMD can improve substantially after removal of the causative factor in drug-induced osteomalacia; however, if patients have underlying risk factors for osteoporosis, low BMD may persist even after osteomalacia resolution, necessitating further evaluation and intervention.<\/jats:p>","DOI":"10.3389\/fendo.2026.1766477","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:41:48Z","timestamp":1773769308000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Adefovir dipivoxil-induced hypophosphatemic osteomalacia and osteoporosis: a case report and literature review"],"prefix":"10.3389","volume":"17","author":[{"given":"Wenshu","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Endocrinology, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxia","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shangyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1043954","article-title":"Tenofovir-induced osteopenia and hyperparathyroidism: 314 A case report and literature review","volume":"13","author":"Zeng","year":"2023","journal-title":"Front Endocrinol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520954713","article-title":"Fanconi syndrome induced by adefovir dipivoxil: a case report and clinical review","volume":"48","author":"Song","year":"2020","journal-title":"J Int Med Res"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.s192632","article-title":"lt;pgt;low-dose adefovir dipivoxilamp;ndash;induced hypophosphatemia osteomalacia in five chronic hepatitis b virusamp;ndash;infected patients. is low-dose adefovir dipivoxilamp;ndash;induced nephrotoxicity completely reversible?lt;\/pgt;","volume":"13","author":"Qian","year":"2019","journal-title":"Drug Des. 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