{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T21:48:47Z","timestamp":1787694527583,"version":"build-2784847793"},"reference-count":301,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Osteoporosis (OP), a widespread metabolic bone condition characterized by diminished bone mass and compromised microarchitecture, poses a significant global health challenge. The gut microbiota (GM) regulates bone homeostasis through the \u201cgut-bone axis,\u201d and this review consolidates its diverse mechanisms. GM-derived metabolites directly\/indirectly modulate osteoclast\/osteoblast activity. GM also regulates systemic immunity to influence the RANKL\/OPG pathway and mediates endocrine signals. Furthermore, it modulates intestinal barrier integrity to facilitate mineral\/vitamin absorption and interacts with the nervous system to form the \u201cmicrobiota-gut-brain-bone\u201d axis. GM imbalance, resulting from factors such as aging, hormonal shifts, or dietary habits, promotes the progression of OP through the perturbation of these networks. This review evaluates the therapeutic potential of GM-targeted interventions, including probiotics, prebiotics, and fecal microbiota transplantation, and underscores the GM as a pivotal therapeutic target, emphasizing that future therapeutic strategies for OP must incorporate the interconnected GM-bone axis for efficacious prevention and treatment.<\/jats:p>","DOI":"10.3389\/fendo.2026.1767726","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:10:11Z","timestamp":1777511411000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Gut microbiota orchestrates bone homeostasis: a multi-pathway network from intestine to skeleton"],"prefix":"10.3389","volume":"17","author":[{"given":"Yanlong","family":"Gong","sequence":"first","affiliation":[{"name":"Intervertebral Disc Center, Affiliated Hospital of Gansu University of Chinese Medicine","place":["Lanzhou, 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