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Moreover, methodologies for the precise recognition and preservation (naked eye, near-infrared autofluorescence, indocyanine green, carbon nanoparticles, and mitoxantrone hydrochloride) of the parathyroid gland during thyroid surgery have been explored, along with recent therapeutic innovations (palopegteriparatide and parathyroid organoids). Finally, this review prospects and interventions via organoids are contemplated. The aim of the literature is to recapitulate the knowledge and the gaps in this field, increasing awareness of postoperative hypoparathyroidism, and improve the prognosis for patients afflicted with hypoparathyroidism.<\/jats:p>","DOI":"10.3389\/fendo.2026.1768391","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:24:51Z","timestamp":1772169891000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Reflections on prevention and treatment of post-thyroidectomy hypoparathyroidism: current management approaches and future prospects"],"prefix":"10.3389","volume":"17","author":[{"given":"Jia","family":"Li","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Pancreatic and Thyroid Surgery, Department of General Surgery, People's Hospital of Zunyi City Bozhou District","place":["Zunyi, China"]},{"name":"Department of Thyroid and Breast Surgery, Department of General 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