{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:13:00Z","timestamp":1793236380640,"version":"4.5.0"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Polycystic Ovarian Syndrome (PCOS) is a hormonal disorder affecting women of reproductive age. It frequently causes hormonal imbalance, irregular menstrual cycle, and in some cases, infertility. For centuries, traditional herbs like Shatavari (Asparagus\n                      <jats:italic>racemosus<\/jats:italic>\n                      Willd.) have been used to support women\u2019s reproductive health, and some studies suggest it may help with PCOS symptoms. Thus, this study aimed to evaluate the safety and efficacy of standardized Shatavari root extract in women with PCOS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, randomized, double-blind, placebo-controlled trial was conducted on women aged 20\u201340 years for 12 weeks. Seventy participants were randomized into Shatavari root extract (SHT, n=35) and placebo (PL, n=35) groups. Sixty-six participants completed the full 12-week trial. The primary outcome was the change in ovarian and endometrial outcomes. Secondary outcomes were the change in Body Mass Index (BMI) and Perceived Stress Scale (PSS-10) scores. Assessments were performed at baseline, week 4, week 8, and week 12. Blood samples were collected at baseline and week 12 to estimate glycated hemoglobin (HbA1c), lipid profile, and serum insulin. The serum hormones, liver, renal, and thyroid functions were also assessed. For the safety assessment, adverse events were continuously monitored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Baseline demographics and clinical parameters were comparable between groups. At 12 weeks, Ovarian volume did not differ significantly between groups (p= 0.254). SHT significantly reduced psychological stress (PSS score: -6.64 \u00b1 3.99; p &amp;lt; 0.0001), decreased follicular count (p &amp;lt; 0.0001), and increased endometrial thickness (p = 0.028) compared to PL. No significant differences were observed in BMI, hormonal levels, or laboratory parameters. No serious adverse events occurred; mild to moderate events were reported in 11.4% (SHT) and 8.5% (PL) of participants, all manageable with standard therapy and not related to the intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Shatavari root extract oral administration can be a safe and effective potential intervention for women with PCOS. The study was registered with the Clinical Trials Registry of India (CTRI) under registration number CTRI\/2024\/10\/074660 on October 3, 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/ctri.nic.in\/Clinicaltrials\/pmaindet2.php?EncHid=MTE0ODIy&amp;amp;Enc=&amp;amp;userName=<\/jats:ext-link>\n                      , identifier CTRI\/2024\/10\/074660.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1769773","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T05:18:49Z","timestamp":1771910329000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and safety of Shatavari root extract in women with Polycystic Ovarian Syndrome: a randomized, double-blind, placebo-controlled trial"],"prefix":"10.3389","volume":"17","author":[{"given":"Yashodhara","family":"Mhatre","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetric, ZOI Fertility","place":["Mumbai, Maharashtra, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Jadhav","sequence":"additional","affiliation":[{"name":"MGM Medical College and Hospital, Nerul, MGMIHS","place":["Navi Mumbai, Maharashtra, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adwait","family":"Malik","sequence":"additional","affiliation":[{"name":"D. Y. Patil University of School and Medicine","place":["Navi Mumbai, Maharashtra, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayakalyani","family":"Srivathsan","sequence":"additional","affiliation":[{"name":"D. Y. Patil University of School and Medicine","place":["Navi Mumbai, Maharashtra, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Langade","sequence":"additional","affiliation":[{"name":"D. Y. Patil University of School and Medicine","place":["Navi Mumbai, Maharashtra, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"B1","article-title":"Awareness of polycystic ovarian disease among females of age group 18\u201330 years","volume":"8","author":"Shenoy","year":"2016","journal-title":"J Pharm Sci Res"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2021.1958310","article-title":"Polycystic ovarian syndrome and infertility: Overview and insights of the putative treatments","volume":"37","author":"Collee","year":"2021","journal-title":"Gynecol Endocrinol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.2147\/IJWH.S113045","article-title":"Treatment options for polycystic ovary syndrome","volume":"3","author":"Badawy","year":"2011","journal-title":"Int J women\u2019s 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