{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T06:09:59Z","timestamp":1771826999088,"version":"3.50.1"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Marine-Lenhart syndrome is a rare clinical condition, and most thyroid nodules combined with Marine-Lenhart syndrome are benign nodules. In this case, Marine-Lenhart syndrome was combined with a malignant nodule and a papillary thyroid carcinoma, which is even rarer.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Case presentation:<\/jats:bold>\n                      We report a case of Marine-Lenhart syndrome in which the 99m TcO4 scan indicated a \u201chot nodule\u201d in the thyroid. However, due to the patient\u2019s thyroid ultrasound revealing a TI-RADS 4a categorized nodule, we performed a thyroid fine-needle aspiration biopsy followed by subsequent thyroid lobectomy with isthmusectomy. Both the results of pathological analysis confirmed the presence of papillary thyroid carcinoma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>After confirming the presence of Graves\u2019 disease, it is still essential to consider the possibility of thyroid hyperfunctioning adenoma, namely Marine-Lenhart syndrome. Although most thyroid nodules associated with Marine-Lenhart syndrome are benign and often present as \u201chot nodules,\u201d it is crucial not to disregard the small probability of thyroid malignancy in such cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1771308","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T05:27:23Z","timestamp":1771824443000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Marine-Lenhart syndrome combined with papillary thyroid carcinoma: a case report"],"prefix":"10.3389","volume":"17","author":[{"given":"Yong","family":"Zhuang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical University","place":["Quanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanrong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shishi Municipal Hospital","place":["Quanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyan","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical University","place":["Quanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huibin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical University","place":["Quanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0801880","article-title":"Clinical practice","volume":"358","author":"Brent","year":"2008","journal-title":"Graves\u2019 Dis N Engl J Med"},{"key":"B2","article-title":"Thyroid nodules in Graves\u2019 disease: implications in an endemically iodine deficient area","volume":"47","author":"Mishra","year":"2001","journal-title":"J Postgrad Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0953-6205(03)00105-5","article-title":"Prevalence of thyroid cancer in Graves\u2019 disease: a retrospective study of a cohort of 103 patients treated surgically","volume":"14","author":"Gerenova","year":"2003","journal-title":"Eur J Intern Med"},{"key":"B4","article-title":"Graves\u2019 disease with functioning nodules (Marine-Lenhart syndrome)","volume":"13","author":"Charkes","year":"1972","journal-title":"J Nucl Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1590\/0004-2730000003173","article-title":"An uncommon case of Marine-Lenhart syndrome","volume":"58","author":"Giuffrida","year":"2014","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1590\/0004-2730000003173","article-title":"Marine-lenhart syndrome","volume":"97","author":"Cakir","year":"2005","journal-title":"J Natl Med Assoc"},{"key":"B7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1258\/shorts.2011.011164","article-title":"The oldest case of Marine-Lenhart syndrome","volume":"3","author":"Brahma","year":"2012","journal-title":"JRSM Short Rep"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199211000-00019","article-title":"Marine-Lenhart syndrome. Graves\u2019 disease with poorly functioning nodules","volume":"17","author":"Chandramouly","year":"1992","journal-title":"Clin Nucl Med"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1053\/adpa.2002.30605","article-title":"Pathology of the autonomously functioning (hot) thyroid nodule","volume":"6","author":"Harach","year":"2002","journal-title":"Ann Diagn Pathol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/S0889-8529(18)30312-8","article-title":"Thyrotoxicosis caused by thyroid cancer","volume":"19","author":"Paul","year":"1990","journal-title":"Endocrinol Metab Clin North Am"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1771308\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T05:27:24Z","timestamp":1771824444000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2026.1771308\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,23]]},"references-count":10,"alternative-id":["10.3389\/fendo.2026.1771308"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2026.1771308","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,23]]},"article-number":"1771308"}}